YER067C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W

Zygosity: Homozygous strain
fixedexpanded
Profile for YER067C-A / YER067C-A

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.69|P-value:9.63E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.71|P-value:7.41E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-2.83|P-value:4.57E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.09|P-value:1.05E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.43|P-value:2.99E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.38|P-value:4.63E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:4.28E-8 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.77|P-value:6.75E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.73|P-value:8.05E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.22|P-value:9.53E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.90|P-value:3.99E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.02|P-value:2.08E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.25|P-value:8.58E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.85|P-value:4.21E-6 ID:SGTC_1741|Compound:st038134|FD-Score:2.73|P-value:8.08E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.73|P-value:8.04E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.82|P-value:4.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.66|P-value:1.14E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.90|P-value:3.21E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-2.95|P-value:2.79E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.69|P-value:8.07E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.95|P-value:1.93E-6 ID:SGTC_2317|Compound:5986382|FD-Score:2.90|P-value:4.01E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.30|P-value:6.54E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.80|P-value:6.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.26|P-value:3.89E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.84|P-value:1.01E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.69|P-value:9.20E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.90|P-value:3.44E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.68|P-value:9.65E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.00|P-value:2.56E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.30|P-value:6.82E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.32|P-value:5.18E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.69|P-value:9.63E-6 ID:SGTC_94|Compound:0334-0113|FD-Score:-2.71|P-value:7.41E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:-2.83|P-value:4.57E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:4.09|P-value:1.05E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.43|P-value:2.99E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.38|P-value:4.63E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.58|P-value:4.28E-8 ID:SGTC_1196|Compound:1588-0294|FD-Score:2.77|P-value:6.75E-4 ID:SGTC_1200|Compound:1643-0193|FD-Score:2.73|P-value:8.05E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.22|P-value:9.53E-5 ID:SGTC_1448|Compound:4255-0083|FD-Score:2.90|P-value:3.99E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.02|P-value:2.08E-4 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.25|P-value:8.58E-5 ID:SGTC_1738|Compound:st035555|FD-Score:3.85|P-value:4.21E-6 ID:SGTC_1741|Compound:st038134|FD-Score:2.73|P-value:8.08E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.73|P-value:8.04E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.82|P-value:4.78E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.66|P-value:1.14E-5 ID:SGTC_2006|Compound:4011487|FD-Score:3.90|P-value:3.21E-6 ID:SGTC_2008|Compound:4012253|FD-Score:-2.95|P-value:2.79E-4 ID:SGTC_2113|Compound:5491891|FD-Score:-2.69|P-value:8.07E-4 ID:SGTC_2285|Compound:7945142|FD-Score:-3.95|P-value:1.93E-6 ID:SGTC_2317|Compound:5986382|FD-Score:2.90|P-value:4.01E-4 ID:SGTC_2375|Compound:9072683|FD-Score:3.30|P-value:6.54E-5 ID:SGTC_2439|Compound:5492030|FD-Score:2.80|P-value:6.03E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.26|P-value:3.89E-7 ID:SGTC_2568|Compound:diosmetin|FD-Score:4.84|P-value:1.01E-8 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.69|P-value:9.20E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-2.90|P-value:3.44E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:2.68|P-value:9.65E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.00|P-value:2.56E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.30|P-value:6.82E-5 ID:SGTC_3283|Compound:9109332|FD-Score:-3.32|P-value:5.18E-5

Top fitness defect scores for YER067C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2568 diosmetin 4.84 100.0 µM 1.01E-8 12 6.55E-7
2 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.26 3.7 µM 3.89E-7 64 1.01E-5
3 SGTC_411 enrofloxacin 4.09 100.0 µM 1.05E-6 DNA damage response 12 2.11E-5
4 SGTC_2006 4011487 3.90 200.0 µM 3.21E-6 endomembrane recycling 81 4.91E-5
5 SGTC_1738 st035555 3.85 74.0 µM 4.21E-6 TSC3-RPN4 35 6.02E-5
6 SGTC_6 0844-0013 3.69 19.8 µM 9.63E-6 118 1.12E-4
7 SGTC_2002 4023503 3.66 131.0 µM 1.14E-5 mitochondrial processes 43 1.27E-4
8 SGTC_1059 3448-6867 3.38 171.0 µM 4.63E-5 27 3.66E-4
9 SGTC_2375 9072683 3.30 200.0 µM 6.54E-5 mitochondrial processes 32 4.76E-4
10 SGTC_2909 7941780 3.30 10.5 µM 6.82E-5 45 4.91E-4
11 SGTC_1586 deoxycorticosterone acetate 3.25 53.7 µM 8.58E-5 31 5.84E-4
12 SGTC_1246 0422-0085 3.22 105.0 µM 9.53E-5 65 6.32E-4
13 SGTC_2871 9038510 3.00 13.0 µM 2.56E-4 53 0.00134
14 SGTC_1448 4255-0083 2.90 152.0 µM 3.99E-4 ERG2 68 0.00187
15 SGTC_2317 5986382 2.90 200.0 µM 4.01E-4 50 0.00188
16 SGTC_2439 5492030 2.80 7.2 µM 6.03E-4 64 0.00256
17 SGTC_1196 1588-0294 2.77 184.0 µM 6.75E-4 69 0.00279
18 SGTC_1783 st039459 2.73 87.5 µM 8.04E-4 Golgi 95 0.00318
19 SGTC_1200 1643-0193 2.73 18.4 µM 8.05E-4 65 0.00319
20 SGTC_1741 st038134 2.73 10.2 µM 8.08E-4 105 0.00320

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 9.00E-61 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.265 3.68E-55 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.261 1.72E-53 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.237 3.01E-44 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.222 9.45E-39 YPR010C RPA135 het RNA polymerase I second largest subunit A135
0.220 6.02E-38 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.211 3.47E-35 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.208 3.25E-34 YLR283W_p YLR283W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
0.207 1.25E-33 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.204 6.02E-33 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.200 1.70E-31 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.199 2.71E-31 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.196 1.62E-30 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.196 2.17E-30 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.195 5.50E-30 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source