YER068C-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YER068C-A / YER068C-A

Click on Significant Values for Screen Details ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.24|P-value:3.24E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.12|P-value:8.50E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.04|P-value:6.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.29|P-value:2.72E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.02|P-value:8.32E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.10|P-value:5.48E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.33|P-value:2.65E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.48|P-value:1.28E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.45|P-value:1.62E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.92|P-value:1.85E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.44|P-value:1.70E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.29|P-value:3.00E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.69|P-value:4.22E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.10|P-value:8.00E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.96|P-value:1.12E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.04|P-value:7.64E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.31|P-value:2.51E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.12|P-value:5.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.32|P-value:2.36E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.10|P-value:6.32E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.03|P-value:7.95E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.20|P-value:4.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:5.90|P-value:3.72E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.32|P-value:2.41E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.70|P-value:5.72E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.05|P-value:7.58E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.96|P-value:9.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.12|P-value:3.77E-8 ID:SGTC_2969|Compound:9091408|FD-Score:4.06|P-value:1.16E-5 ID:SGTC_3211|Compound:9128781|FD-Score:5.22|P-value:2.56E-8 ID:SGTC_3277|Compound:9138724|FD-Score:-3.51|P-value:1.11E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.02|P-value:7.48E-4 ID:SGTC_41|Compound:0478-0632|FD-Score:3.28|P-value:3.14E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.24|P-value:3.24E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.12|P-value:8.50E-6 ID:SGTC_144|Compound:4161-2749|FD-Score:-3.04|P-value:6.99E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.29|P-value:2.72E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.02|P-value:8.32E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.10|P-value:5.48E-4 ID:SGTC_412|Compound:gemfibrozil|FD-Score:-4.33|P-value:2.65E-6 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.48|P-value:1.28E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:3.45|P-value:1.62E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-3.39|P-value:1.78E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.92|P-value:1.85E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:3.44|P-value:1.70E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.29|P-value:3.00E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.69|P-value:4.22E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:-4.10|P-value:8.00E-6 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.96|P-value:1.12E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.04|P-value:7.64E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.31|P-value:2.51E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.12|P-value:5.76E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.32|P-value:2.36E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.10|P-value:6.32E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.03|P-value:7.95E-4 ID:SGTC_2051|Compound:5263410|FD-Score:3.20|P-value:4.25E-4 ID:SGTC_2058|Compound:5236698|FD-Score:5.90|P-value:3.72E-10 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.32|P-value:2.41E-4 ID:SGTC_2425|Compound:5628681|FD-Score:3.70|P-value:5.72E-5 ID:SGTC_2487|Compound:5918373|FD-Score:3.05|P-value:7.58E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.53|P-value:1.20E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-2.96|P-value:9.24E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-5.12|P-value:3.77E-8 ID:SGTC_2969|Compound:9091408|FD-Score:4.06|P-value:1.16E-5 ID:SGTC_3211|Compound:9128781|FD-Score:5.22|P-value:2.56E-8 ID:SGTC_3277|Compound:9138724|FD-Score:-3.51|P-value:1.11E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.02|P-value:7.48E-4

Top fitness defect scores for YER068C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2058 5236698 5.90 133.0 µM 3.72E-10 9 1.85E-9
2 SGTC_3211 9128781 5.22 49.5 µM 2.56E-8 31 8.96E-8
3 SGTC_1212 0520-0165 4.96 585.0 µM 1.12E-7 8 3.48E-7
4 SGTC_54 0159-0055 4.12 9.0 µM 8.50E-6 ERG2 43 1.86E-5
5 SGTC_2969 9091408 4.06 28.7 µM 1.16E-5 23 2.46E-5
6 SGTC_2425 5628681 3.70 7.8 µM 5.72E-5 34 1.07E-4
7 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.53 100.0 µM 1.20E-4 34 2.12E-4
8 SGTC_929 2805-0021 3.45 398.0 µM 1.62E-4 21 2.80E-4
9 SGTC_966 1300-0360 3.44 30.2 µM 1.70E-4 heme requiring 43 2.91E-4
10 SGTC_995 3931-2021 3.29 34.6 µM 3.00E-4 RPP1 & pyrimidine depletion 39 4.94E-4
11 SGTC_41 0478-0632 3.28 82.6 µM 3.14E-4 57 5.15E-4
12 SGTC_2051 5263410 3.20 176.0 µM 4.25E-4 40 6.80E-4
13 SGTC_1919 st067113 3.12 52.3 µM 5.76E-4 TSC3-RPN4 68 8.99E-4
14 SGTC_1940 st075990 3.10 51.1 µM 6.32E-4 60S ribosome export 57 9.81E-4
15 SGTC_2487 5918373 3.05 44.0 µM 7.58E-4 52 0.00116
16 SGTC_1412 3909-8563 3.04 178.0 µM 7.64E-4 43 0.00117
17 SGTC_1975 st070967 3.03 30.8 µM 7.95E-4 80 0.00121
18 SGTC_152 4469-0003 3.02 551.2 µM 8.32E-4 50 0.00126
19 SGTC_874 0599-0792 2.93 117.0 µM 0.00114 87 0.00169
20 SGTC_1414 3917-0015 2.87 5.4 µM 0.00139 46 0.00203

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.222 1.34E-38 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.216 7.92E-37 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 4.68E-35 YLR210W CLB4 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
0.201 1.06E-31 YOL140W ARG8 hom Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
0.201 9.17E-32 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.196 2.75E-30 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.190 1.33E-28 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.183 1.53E-26 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.180 7.88E-26 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.178 3.05E-25 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.168 1.02E-22 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.165 8.84E-22 YDR411C DFM1 hom Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p
0.163 1.77E-21 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.156 1.07E-19 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.149 3.50E-18 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS