YER071C_p / TDA2

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele

Zygosity: Homozygous strain
fixedexpanded
Profile for YER071C / TDA2

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.55|P-value:4.53E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.96|P-value:5.43E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.03|P-value:4.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.08|P-value:3.51E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.40|P-value:8.99E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.01|P-value:4.37E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.87|P-value:9.58E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.93|P-value:6.06E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.38|P-value:9.53E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.13|P-value:3.66E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.48|P-value:6.17E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.35|P-value:1.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.72|P-value:1.04E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.20|P-value:2.63E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.00|P-value:5.82E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-2.88|P-value:7.21E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.50|P-value:5.59E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.01|P-value:5.64E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.40|P-value:8.70E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.02|P-value:5.35E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.90|P-value:8.52E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:3.35E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.61|P-value:2.66E-7 ID:SGTC_2000|Compound:st075254|FD-Score:-3.34|P-value:1.17E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.06|P-value:3.67E-4 ID:SGTC_2119|Compound:5528445|FD-Score:5.36|P-value:2.72E-9 ID:SGTC_2124|Compound:5246320|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:4.98E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-7.50|P-value:9.22E-17 ID:SGTC_2686|Compound:alizarin|FD-Score:3.80|P-value:1.90E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:2.94|P-value:7.16E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.59|P-value:2.23E-7 ID:SGTC_2949|Compound:9072542|FD-Score:-2.85|P-value:8.29E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.14|P-value:3.35E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.23|P-value:2.29E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.67|P-value:1.38E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.49|P-value:5.80E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.55|P-value:4.53E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:-2.96|P-value:5.43E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:-3.03|P-value:4.07E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.08|P-value:3.51E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:-3.40|P-value:8.99E-5 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.01|P-value:4.37E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:2.87|P-value:9.58E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-2.93|P-value:6.06E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.38|P-value:9.53E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.13|P-value:3.66E-6 ID:SGTC_917|Compound:harmaline|FD-Score:3.20|P-value:2.67E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-3.48|P-value:6.17E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.35|P-value:1.42E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.72|P-value:1.04E-7 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.20|P-value:2.63E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:3.15|P-value:3.18E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.00|P-value:5.82E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:-2.88|P-value:7.21E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:-3.50|P-value:5.59E-5 ID:SGTC_1586|Compound:deoxycorticosterone acetate|FD-Score:3.01|P-value:5.64E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:-3.40|P-value:8.70E-5 ID:SGTC_1810|Compound:st050138|FD-Score:3.02|P-value:5.35E-4 ID:SGTC_1906|Compound:st060206|FD-Score:2.90|P-value:8.52E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.67|P-value:3.35E-5 ID:SGTC_1914|Compound:st062367|FD-Score:4.61|P-value:2.66E-7 ID:SGTC_2000|Compound:st075254|FD-Score:-3.34|P-value:1.17E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-3.17|P-value:2.31E-4 ID:SGTC_2116|Compound:5511452|FD-Score:-3.06|P-value:3.67E-4 ID:SGTC_2119|Compound:5528445|FD-Score:5.36|P-value:2.72E-9 ID:SGTC_2124|Compound:5246320|FD-Score:3.19|P-value:2.75E-4 ID:SGTC_2199|Compound:6590217|FD-Score:-2.98|P-value:4.98E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-7.50|P-value:9.22E-17 ID:SGTC_2686|Compound:alizarin|FD-Score:3.80|P-value:1.90E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:2.94|P-value:7.16E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.59|P-value:2.23E-7 ID:SGTC_2949|Compound:9072542|FD-Score:-2.85|P-value:8.29E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.14|P-value:3.35E-4 ID:SGTC_3102|Compound:9121669|FD-Score:3.35|P-value:1.40E-4 ID:SGTC_3104|Compound:9120930|FD-Score:3.23|P-value:2.29E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-4.67|P-value:1.38E-7 ID:SGTC_3294|Compound:9122953|FD-Score:-3.49|P-value:5.80E-5

Top fitness defect scores for YER071C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2119 5528445 5.36 120.6 µM 2.72E-9 4 4.09E-8
2 SGTC_1914 st062367 4.61 72.6 µM 2.66E-7 11 1.97E-6
3 SGTC_916 4466-0038 4.13 42.0 nM 3.66E-6 cell wall 62 1.82E-5
4 SGTC_2686 alizarin 3.80 95.4 µM 1.90E-5 RPP1 & pyrimidine depletion 36 7.34E-5
5 SGTC_1908 st060353 3.67 56.5 µM 3.35E-5 RPP1 & pyrimidine depletion 48 1.19E-4
6 SGTC_3102 9121669 3.35 49.5 µM 1.40E-4 18 4.01E-4
7 SGTC_1040 k898-0338 3.35 155.0 µM 1.42E-4 38 4.07E-4
8 SGTC_3104 9120930 3.23 49.5 µM 2.29E-4 31 6.11E-4
9 SGTC_1175 0741-0056 3.20 27.6 µM 2.63E-4 55 6.87E-4
10 SGTC_917 harmaline 3.20 728.1 nM 2.67E-4 ergosterol biosynthesis 58 6.97E-4
11 SGTC_2124 5246320 3.19 200.0 µM 2.75E-4 heme biosynthesis & mitochondrial translocase 47 7.13E-4
12 SGTC_1177 0983-0204 3.15 23.6 µM 3.18E-4 38 8.08E-4
13 SGTC_2962 9082311 3.14 13.2 µM 3.35E-4 59 8.45E-4
14 SGTC_1810 st050138 3.02 53.0 µM 5.35E-4 PDR1 34 0.00126
15 SGTC_1586 deoxycorticosterone acetate 3.01 53.7 µM 5.64E-4 44 0.00132
16 SGTC_1198 1612-1005 3.00 86.7 µM 5.82E-4 50 0.00135
17 SGTC_2774 tamoxifen 2.94 10.9 µM 7.16E-4 53 0.00162
18 SGTC_1906 st060206 2.90 94.7 µM 8.52E-4 76 0.00187
19 SGTC_757 1066-0008 2.87 322.0 µM 9.58E-4 Golgi 71 0.00207
20 SGTC_75 0159-0059 2.85 199.0 µM 0.00101 fatty acid desaturase (OLE1) 79 0.00216

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.316 2.54E-78 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.298 1.57E-69 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.268 4.86E-56 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.260 6.32E-53 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.255 9.90E-51 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.230 1.80E-41 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.228 1.05E-40 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.228 1.27E-40 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.211 5.89E-35 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.210 9.28E-35 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.209 2.05E-34 YMR147W_p YMR147W_p hom Putative protein of unknown function
0.205 4.01E-33 YKR023W_p YKR023W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.199 2.60E-31 YLR346C_p YLR346C_p hom Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
0.198 7.66E-31 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.187 9.66E-28 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth