YER077C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YER077C / YER077C

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:2.38E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.72|P-value:8.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.03|P-value:6.83E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:6.78|P-value:5.69E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:4.19|P-value:2.09E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.61|P-value:1.17E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:5.18|P-value:6.64E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:3.70|P-value:9.20E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.34|P-value:1.29E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.73|P-value:8.56E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.76|P-value:7.51E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.13|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.00|P-value:1.42E-20 ID:SGTC_195|Compound:4234-0266|FD-Score:3.98|P-value:4.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:7.20E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.60|P-value:1.20E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:12.80|P-value:1.76E-27 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.79|P-value:6.80E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.73|P-value:8.22E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.20|P-value:5.95E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:5.59|P-value:1.27E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.45|P-value:2.69E-8 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.70|P-value:8.87E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.11|P-value:2.71E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.27|P-value:1.63E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.87|P-value:5.61E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.54|P-value:6.64E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:4.17|P-value:2.24E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.11|P-value:8.40E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.94|P-value:1.64E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.51|P-value:1.79E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.69|P-value:9.56E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-4.00|P-value:3.67E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.17|P-value:2.22E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.38|P-value:2.83E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.34|P-value:3.30E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.69|P-value:9.05E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.94|P-value:1.56E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.15|P-value:2.41E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.97|P-value:4.03E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.79|P-value:6.97E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-4.10|P-value:2.71E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.37|P-value:1.17E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.82|P-value:6.60E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.72|P-value:8.70E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.62|P-value:4.99E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.12|P-value:2.53E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.75|P-value:7.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.31|P-value:3.83E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-6.83|P-value:4.27E-9 ID:SGTC_2707|Compound:st078556|FD-Score:4.05|P-value:3.28E-4 ID:SGTC_2711|Compound:st079103|FD-Score:4.33|P-value:1.37E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.68|P-value:9.39E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.28|P-value:1.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.20|P-value:1.58E-21 ID:SGTC_2905|Compound:7799065|FD-Score:-5.32|P-value:3.61E-6 ID:SGTC_3010|Compound:9080089|FD-Score:4.62|P-value:4.98E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.88|P-value:5.43E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.08|P-value:9.65E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.75|P-value:7.66E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.27|P-value:4.56E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-4.61|P-value:4.97E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-4.15|P-value:2.31E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:5.44|P-value:2.38E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.72|P-value:8.88E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.03|P-value:6.83E-12 ID:SGTC_63|Compound:0099-0242|FD-Score:6.78|P-value:5.69E-9 ID:SGTC_68|Compound:0986-0284|FD-Score:4.19|P-value:2.09E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.61|P-value:1.17E-6 ID:SGTC_88|Compound:0180-0332|FD-Score:5.18|P-value:6.64E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:3.70|P-value:9.20E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.34|P-value:1.29E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.73|P-value:8.56E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.76|P-value:7.51E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:4.13|P-value:2.54E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:11.00|P-value:1.42E-20 ID:SGTC_195|Compound:4234-0266|FD-Score:3.98|P-value:4.05E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:7.20E-26 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.60|P-value:1.20E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:12.80|P-value:1.76E-27 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.79|P-value:6.80E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.73|P-value:8.22E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:5.20|P-value:5.95E-6 ID:SGTC_530|Compound:4358-1714|FD-Score:5.59|P-value:1.27E-6 ID:SGTC_568|Compound:1193-0097|FD-Score:-6.45|P-value:2.69E-8 ID:SGTC_586|Compound:0957-0265|FD-Score:-3.70|P-value:8.87E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:4.11|P-value:2.71E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:4.27|P-value:1.63E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.87|P-value:5.61E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:4.54|P-value:6.64E-5 ID:SGTC_895|Compound:0964-0006|FD-Score:4.17|P-value:2.24E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:5.11|P-value:8.40E-6 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.94|P-value:1.64E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:5.51|P-value:1.79E-6 ID:SGTC_1578|Compound:josamycin|FD-Score:3.69|P-value:9.56E-4 ID:SGTC_1656|Compound:st012921|FD-Score:-4.00|P-value:3.67E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.17|P-value:2.22E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-5.38|P-value:2.83E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:-5.34|P-value:3.30E-6 ID:SGTC_1742|Compound:st038235|FD-Score:6.69|P-value:9.05E-9 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.94|P-value:1.56E-5 ID:SGTC_1807|Compound:st050092|FD-Score:4.15|P-value:2.41E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.97|P-value:4.03E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-3.79|P-value:6.97E-4 ID:SGTC_2045|Compound:5106652|FD-Score:4.15|P-value:2.37E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-4.10|P-value:2.71E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.37|P-value:1.17E-4 ID:SGTC_2295|Compound:7971645|FD-Score:3.82|P-value:6.60E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.72|P-value:8.70E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.62|P-value:4.99E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:-4.12|P-value:2.53E-4 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.75|P-value:7.63E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.31|P-value:3.83E-10 ID:SGTC_2698|Compound:st077697|FD-Score:-6.83|P-value:4.27E-9 ID:SGTC_2707|Compound:st078556|FD-Score:4.05|P-value:3.28E-4 ID:SGTC_2711|Compound:st079103|FD-Score:4.33|P-value:1.37E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-3.68|P-value:9.39E-4 ID:SGTC_2858|Compound:9025781|FD-Score:-4.28|P-value:1.50E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.20|P-value:1.58E-21 ID:SGTC_2905|Compound:7799065|FD-Score:-5.32|P-value:3.61E-6 ID:SGTC_3010|Compound:9080089|FD-Score:4.62|P-value:4.98E-5 ID:SGTC_3011|Compound:9081274|FD-Score:3.88|P-value:5.43E-4 ID:SGTC_3020|Compound:9089140|FD-Score:5.08|P-value:9.65E-6 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.75|P-value:7.66E-4 ID:SGTC_3212|Compound:9128307|FD-Score:5.27|P-value:4.56E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-4.61|P-value:4.97E-5 ID:SGTC_3329|Compound:9141233|FD-Score:-4.15|P-value:2.31E-4

Top fitness defect scores for YER077C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 12.80 1.1 µM 1.76E-27 mitochondrial stress 19 6.29E-38
2 SGTC_236 1509-0011 12.40 5.3 µM 7.20E-26 142 1.16E-35
3 SGTC_173 1273-0061 11.00 2.7 µM 1.42E-20 mitochondrial stress 33 3.18E-28
4 SGTC_58 0957-0393 8.03 9.0 µM 6.83E-12 cell wall 122 4.86E-16
5 SGTC_2688 kanamycin b 7.31 96.7 µM 3.83E-10 calcium & mitochondrial duress 94 1.37E-13
6 SGTC_63 0099-0242 6.78 26.7 µM 5.69E-9 mitochondrial stress 20 5.96E-12
7 SGTC_1742 st038235 6.69 28.9 µM 9.05E-9 mitochondrial stress 30 1.14E-11
8 SGTC_70 0141-0289 5.61 43.3 µM 1.17E-6 mitochondrial stress 94 1.02E-8
9 SGTC_275 trichlorophene 5.60 5.7 µM 1.20E-6 mitochondrial stress 134 1.05E-8
10 SGTC_530 4358-1714 5.59 28.0 µM 1.27E-6 10 1.13E-8
11 SGTC_1178 0988-0033 5.51 191.0 µM 1.79E-6 6 1.83E-8
12 SGTC_10 0279-0212 5.44 42.6 µM 2.38E-6 TRP & mitochondrial translation 43 2.73E-8
13 SGTC_3212 9128307 5.27 49.5 µM 4.56E-6 23 6.74E-8
14 SGTC_525 k781-2675 5.20 26.7 µM 5.95E-6 redox potentiating 30 9.77E-8
15 SGTC_88 0180-0332 5.18 8.7 µM 6.64E-6 4 1.14E-7
16 SGTC_1017 4239-0030 5.11 168.0 µM 8.40E-6 7 1.58E-7
17 SGTC_3020 9089140 5.08 49.5 µM 9.65E-6 8 1.91E-7
18 SGTC_1177 0983-0204 4.94 23.6 µM 1.64E-5 4 4.00E-7
19 SGTC_3010 9080089 4.62 71.4 µM 4.98E-5 5 1.87E-6
20 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.62 13.2 µM 4.99E-5 13 1.88E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.465 1.25E-179 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.459 3.61E-174 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.458 5.70E-174 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.455 1.14E-170 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.454 1.77E-170 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.453 1.78E-169 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.451 4.39E-168 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.449 3.98E-166 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.449 4.18E-166 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.444 8.41E-162 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.443 6.05E-161 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.432 7.28E-153 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.430 6.74E-151 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.427 1.03E-148 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.421 2.73E-144 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency