YER078C / ICP55

Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family

Zygosity: Homozygous strain
fixedexpanded
Profile for YER078C / ICP55

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.35|P-value:4.63E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.31|P-value:3.73E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.81|P-value:5.28E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.33|P-value:3.46E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.06|P-value:8.54E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.99|P-value:5.11E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:1.65E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.67|P-value:9.29E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.36|P-value:3.15E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.92|P-value:3.21E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.98|P-value:1.88E-7 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.54|P-value:1.56E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.76|P-value:6.50E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.19|P-value:5.30E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.05|P-value:8.72E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-5.35|P-value:2.13E-8 ID:SGTC_1609|Compound:st001574|FD-Score:3.15|P-value:6.75E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.04|P-value:1.94E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.72|P-value:7.44E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.10|P-value:7.34E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.03|P-value:9.41E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.90|P-value:3.61E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-4.01|P-value:1.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.61|P-value:1.31E-6 ID:SGTC_2380|Compound:9035439|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.28|P-value:3.56E-8 ID:SGTC_2623|Compound:humulene|FD-Score:5.18|P-value:6.25E-8 ID:SGTC_2863|Compound:9028737|FD-Score:3.27|P-value:4.29E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.23|P-value:4.63E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.45|P-value:2.93E-6 ID:SGTC_3127|Compound:9126946|FD-Score:3.14|P-value:7.06E-4 ID:SGTC_3176|Compound:9106582|FD-Score:3.23|P-value:4.95E-4 ID:SGTC_35|Compound:0133-0054|FD-Score:4.35|P-value:4.63E-6 ID:SGTC_97|Compound:0535-0701|FD-Score:3.31|P-value:3.73E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.81|P-value:5.28E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:3.33|P-value:3.46E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.18|P-value:6.11E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:3.48|P-value:1.99E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:-3.30|P-value:3.55E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:-3.06|P-value:8.54E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:5.99|P-value:5.11E-10 ID:SGTC_927|Compound:2425-1185|FD-Score:3.53|P-value:1.65E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:3.67|P-value:9.29E-5 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.36|P-value:3.15E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:3.42|P-value:2.51E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.92|P-value:3.21E-5 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.98|P-value:1.88E-7 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.54|P-value:1.56E-4 ID:SGTC_1473|Compound:k844-0725|FD-Score:3.76|P-value:6.50E-5 ID:SGTC_1474|Compound:0330-0125|FD-Score:-3.19|P-value:5.30E-4 ID:SGTC_1523|Compound:st012844|FD-Score:-3.05|P-value:8.72E-4 ID:SGTC_1558|Compound:st069300|FD-Score:-5.35|P-value:2.13E-8 ID:SGTC_1609|Compound:st001574|FD-Score:3.15|P-value:6.75E-4 ID:SGTC_1891|Compound:st059073|FD-Score:4.04|P-value:1.94E-5 ID:SGTC_1977|Compound:st070720|FD-Score:3.72|P-value:7.44E-5 ID:SGTC_2063|Compound:5246145|FD-Score:3.22|P-value:5.27E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.10|P-value:7.34E-4 ID:SGTC_2166|Compound:5933061|FD-Score:-3.03|P-value:9.41E-4 ID:SGTC_2263|Compound:7948595|FD-Score:3.90|P-value:3.61E-5 ID:SGTC_2280|Compound:7785178|FD-Score:-4.01|P-value:1.99E-5 ID:SGTC_2289|Compound:7946404|FD-Score:4.61|P-value:1.31E-6 ID:SGTC_2380|Compound:9035439|FD-Score:3.11|P-value:7.71E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:5.28|P-value:3.56E-8 ID:SGTC_2623|Compound:humulene|FD-Score:5.18|P-value:6.25E-8 ID:SGTC_2863|Compound:9028737|FD-Score:3.27|P-value:4.29E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-3.23|P-value:4.63E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.45|P-value:2.93E-6 ID:SGTC_3127|Compound:9126946|FD-Score:3.14|P-value:7.06E-4 ID:SGTC_3176|Compound:9106582|FD-Score:3.23|P-value:4.95E-4

Top fitness defect scores for YER078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_910 3454-3003 5.99 490.0 µM 5.11E-10 1 1.07E-9
2 SGTC_2527 2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone 5.28 63.6 µM 3.56E-8 21 6.30E-8
3 SGTC_2623 humulene 5.18 100.0 µM 6.25E-8 8 1.08E-7
4 SGTC_1303 1160-0052 4.98 261.0 µM 1.88E-7 3 3.12E-7
5 SGTC_2289 7946404 4.61 165.1 µM 1.31E-6 72 2.02E-6
6 SGTC_2943 9068529 4.45 45.3 µM 2.93E-6 8 4.37E-6
7 SGTC_35 0133-0054 4.35 64.1 µM 4.63E-6 24 6.79E-6
8 SGTC_1891 st059073 4.04 26.2 µM 1.94E-5 TSC3-RPN4 21 2.69E-5
9 SGTC_1153 4055-0057 3.92 267.0 µM 3.21E-5 26 4.37E-5
10 SGTC_2263 7948595 3.90 193.3 µM 3.61E-5 4 4.90E-5
11 SGTC_139 0099-0334 3.81 718.6 µM 5.28E-5 34 7.06E-5
12 SGTC_1473 k844-0725 3.76 134.0 µM 6.50E-5 20 8.62E-5
13 SGTC_1977 st070720 3.72 65.3 µM 7.44E-5 14 9.81E-5
14 SGTC_1027 k015-0025 3.67 8.7 µM 9.29E-5 32 1.22E-4
15 SGTC_1340 1486-1359 3.54 257.0 µM 1.56E-4 37 2.00E-4
16 SGTC_927 2425-1185 3.53 123.0 µM 1.65E-4 43 2.11E-4
17 SGTC_522 1273-0010 3.48 11.6 µM 1.99E-4 60S ribosome export 36 2.53E-4
18 SGTC_1112 tnp00069 3.42 1.2 µM 2.51E-4 44 3.16E-4
19 SGTC_1099 5-nonyloxytryptamine 3.36 2.9 µM 3.15E-4 41 3.94E-4
20 SGTC_167 3672-0051 3.33 66.2 µM 3.46E-4 64 4.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.106 6.30E-10 YDL117W CYK3 hom SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants
0.094 4.98E-8 YJL206C_p YJL206C_p hom Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment
0.093 6.18E-8 YPL006W NCR1 hom Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
0.089 2.09E-7 YPL257W_p YPL257W_p hom Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
0.084 1.15E-6 YPL096C-A ERI1 hom Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein
0.080 3.67E-6 YMR306W FKS3 hom Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.078 5.64E-6 YJL199C_d MBB1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
0.076 1.03E-5 YOR154W_p SLP1_p hom Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p
0.076 1.19E-5 YPR096C YPR096C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.072 3.28E-5 YNL006W LST8 het Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
0.069 6.56E-5 YCL052C PBN1 het Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
0.069 6.69E-5 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.069 7.13E-5 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.068 7.91E-5 YGL214W_d YGL214W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C
0.068 7.98E-5 YLR107W REX3 hom RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases