YER081W / SER3

3-phosphoglycerate dehydrogenase; catalyzes the first step in serine and glycine biosynthesis; SER3 has a paralog, SER33, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER081W / SER3

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-3.44|P-value:3.17E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.35|P-value:4.40E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.21|P-value:7.16E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.75|P-value:9.94E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.62|P-value:1.63E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.27|P-value:1.13E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.22|P-value:6.98E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:5.01|P-value:3.31E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.47|P-value:2.89E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.50|P-value:2.57E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.29|P-value:1.01E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.12|P-value:9.80E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.51|P-value:2.41E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.23|P-value:6.71E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.49|P-value:4.23E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.15|P-value:8.66E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.34|P-value:4.60E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.13|P-value:2.07E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.26|P-value:5.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.39|P-value:3.75E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-3.47|P-value:2.91E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.38|P-value:4.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.82|P-value:7.30E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.36|P-value:4.21E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-4.83|P-value:7.99E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.72|P-value:1.10E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.13|P-value:9.51E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.03|P-value:3.15E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.13|P-value:9.53E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.32|P-value:9.00E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-4.37|P-value:7.20E-6 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.44|P-value:3.17E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:-3.35|P-value:4.40E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.21|P-value:7.16E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.75|P-value:9.94E-5 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.62|P-value:1.63E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:4.27|P-value:1.13E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:-3.22|P-value:6.98E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:5.01|P-value:3.31E-7 ID:SGTC_359|Compound:0081-0058|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:3.47|P-value:2.89E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:3.50|P-value:2.57E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:4.29|P-value:1.01E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.12|P-value:9.80E-4 ID:SGTC_865|Compound:0488-0499|FD-Score:3.51|P-value:2.41E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.23|P-value:6.71E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-4.49|P-value:4.23E-6 ID:SGTC_1078|Compound:idebenone|FD-Score:3.15|P-value:8.66E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:-3.34|P-value:4.60E-4 ID:SGTC_1086|Compound:cerivastatin|FD-Score:4.13|P-value:2.07E-5 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.26|P-value:5.93E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.39|P-value:3.75E-4 ID:SGTC_1651|Compound:st011928|FD-Score:-3.47|P-value:2.91E-4 ID:SGTC_1756|Compound:st041558|FD-Score:-3.38|P-value:4.01E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.82|P-value:7.30E-5 ID:SGTC_2067|Compound:5224629|FD-Score:-3.36|P-value:4.21E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.49|P-value:2.60E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-4.83|P-value:7.99E-7 ID:SGTC_2447|Compound:5741742|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_2450|Compound:5739737|FD-Score:-3.72|P-value:1.10E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-3.13|P-value:9.51E-4 ID:SGTC_2802|Compound:7925815|FD-Score:4.03|P-value:3.15E-5 ID:SGTC_2886|Compound:9058944|FD-Score:3.44|P-value:3.11E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.22|P-value:6.92E-4 ID:SGTC_2891|Compound:9063876|FD-Score:3.21|P-value:7.06E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.13|P-value:9.53E-4 ID:SGTC_2899|Compound:9053889|FD-Score:4.32|P-value:9.00E-6 ID:SGTC_3221|Compound:9128209|FD-Score:-4.37|P-value:7.20E-6

Top fitness defect scores for YER081W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_259 usnic acid 5.01 108.9 µM 3.31E-7 5 2.77E-7
2 SGTC_2899 9053889 4.32 58.4 µM 9.00E-6 5 7.89E-6
3 SGTC_756 0508-1999 4.29 28.3 µM 1.01E-5 RPP1 & pyrimidine depletion 17 8.90E-6
4 SGTC_194 1486-1323 4.27 56.9 µM 1.13E-5 12 9.92E-6
5 SGTC_1086 cerivastatin 4.13 2.2 µM 2.07E-5 azole & statin 10 1.83E-5
6 SGTC_2802 7925815 4.03 54.5 µM 3.15E-5 38 2.80E-5
7 SGTC_1762 st045503 3.82 25.5 µM 7.30E-5 29 6.58E-5
8 SGTC_139 0099-0334 3.75 718.6 µM 9.94E-5 38 8.99E-5
9 SGTC_359 0081-0058 3.70 15.9 µM 1.20E-4 60S ribosome export 54 1.09E-4
10 SGTC_865 0488-0499 3.51 301.0 µM 2.41E-4 27 2.21E-4
11 SGTC_654 1124-0271 3.50 80.9 µM 2.57E-4 43 2.36E-4
12 SGTC_2114 5491910 3.49 81.2 µM 2.60E-4 24 2.38E-4
13 SGTC_535 2293-4129 3.47 48.2 µM 2.89E-4 NEO1 85 2.65E-4
14 SGTC_2886 9058944 3.44 52.0 µM 3.11E-4 4 2.86E-4
15 SGTC_1625 st003711 3.39 30.1 µM 3.75E-4 calcium & mitochondrial duress 59 3.45E-4
16 SGTC_2447 5741742 3.32 33.8 µM 4.84E-4 51 4.47E-4
17 SGTC_1444 4112-3581 3.26 28.0 µM 5.93E-4 34 5.50E-4
18 SGTC_1017 4239-0030 3.23 168.0 µM 6.71E-4 57 6.23E-4
19 SGTC_2890 9046729 3.22 58.4 µM 6.92E-4 Golgi 42 6.42E-4
20 SGTC_2891 9063876 3.21 19.5 µM 7.06E-4 19 6.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 3.97E-17 YNL277W-A_p YNL277W-A_p hom Putative protein of unknown function
0.101 5.04E-9 YJL208C NUC1 hom Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
0.099 8.07E-9 YJL061W NUP82 het Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p)
0.094 5.33E-8 YIL120W QDR1 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication
0.093 6.65E-8 YIL051C MMF1 het Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes
0.090 1.79E-7 YOR329C SCD5 het Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency
0.090 2.01E-7 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.089 2.21E-7 YGL039W YGL039W hom Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols
0.082 1.80E-6 YCL009C ILV6 hom Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria
0.081 2.74E-6 YLR435W TSR2 hom Protein with a potential role in pre-rRNA processing
0.079 4.13E-6 YNL312W RFA2 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.077 7.99E-6 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.077 8.79E-6 YMR261C TPS3 hom Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication
0.074 1.62E-5 YNL172W APC1 het Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
0.074 1.62E-5 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W