YER084W_p

Protein of unknown function; expressed at both mRNA and protein levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YER084W / YER084W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.32|P-value:8.70E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:6.80|P-value:7.60E-11 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.45|P-value:6.34E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.47|P-value:1.07E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:3.68|P-value:2.57E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.88|P-value:1.27E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:15.70|P-value:7.00E-50 ID:SGTC_163|Compound:1327-0036|FD-Score:3.75|P-value:2.03E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.34|P-value:8.09E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.29|P-value:9.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.51|P-value:4.60E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:13.50|P-value:4.92E-37 ID:SGTC_384|Compound:k007-0144|FD-Score:12.70|P-value:4.46E-33 ID:SGTC_426|Compound:0988-0037|FD-Score:3.89|P-value:1.24E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.98|P-value:8.88E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.69|P-value:2.48E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.20|P-value:3.95E-26 ID:SGTC_575|Compound:k072-0246|FD-Score:4.99|P-value:1.33E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-4.15|P-value:5.07E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.56|P-value:8.63E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.47|P-value:5.39E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.38|P-value:9.78E-10 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.97|P-value:9.23E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.20|P-value:4.26E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:10.80|P-value:1.80E-24 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.97|P-value:1.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.30|P-value:2.86E-47 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.93|P-value:1.18E-8 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.02|P-value:7.62E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.88|P-value:1.25E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.43|P-value:6.81E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.94|P-value:1.13E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.84|P-value:2.96E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.61|P-value:6.96E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.35|P-value:7.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.57|P-value:8.97E-8 ID:SGTC_1738|Compound:st035555|FD-Score:-3.37|P-value:8.20E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.72|P-value:1.92E-13 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.29|P-value:9.45E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.65|P-value:2.84E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.81|P-value:1.82E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.90|P-value:1.31E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.50|P-value:5.29E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.46|P-value:5.60E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.54|P-value:4.18E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.48|P-value:5.64E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.58|P-value:3.67E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.40|P-value:1.65E-12 ID:SGTC_2343|Compound:7990716|FD-Score:4.68|P-value:5.23E-6 ID:SGTC_2347|Compound:9049783|FD-Score:3.67|P-value:2.73E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.91|P-value:1.25E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.27|P-value:3.23E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.26|P-value:2.97E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.96|P-value:9.55E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:2.12E-27 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.27|P-value:3.51E-7 ID:SGTC_2823|Compound:7987624|FD-Score:5.63|P-value:5.87E-8 ID:SGTC_2824|Compound:7998404|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_2966|Compound:9084041|FD-Score:-3.89|P-value:1.35E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.70|P-value:4.09E-8 ID:SGTC_3008|Compound:9078912|FD-Score:4.02|P-value:7.48E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.30|P-value:9.31E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.46|P-value:5.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.48|P-value:5.61E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.32|P-value:8.70E-4 ID:SGTC_81|Compound:0411-0046|FD-Score:6.80|P-value:7.60E-11 ID:SGTC_85|Compound:0868-0259|FD-Score:-3.45|P-value:6.34E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:7.47|P-value:1.07E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:3.68|P-value:2.57E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.88|P-value:1.27E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:15.70|P-value:7.00E-50 ID:SGTC_163|Compound:1327-0036|FD-Score:3.75|P-value:2.03E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.34|P-value:8.09E-4 ID:SGTC_263|Compound:alizarin|FD-Score:3.29|P-value:9.60E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:6.51|P-value:4.60E-10 ID:SGTC_373|Compound:0844-0104|FD-Score:13.50|P-value:4.92E-37 ID:SGTC_384|Compound:k007-0144|FD-Score:12.70|P-value:4.46E-33 ID:SGTC_426|Compound:0988-0037|FD-Score:3.89|P-value:1.24E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.98|P-value:8.88E-9 ID:SGTC_543|Compound:3844-1095|FD-Score:3.69|P-value:2.48E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:11.20|P-value:3.95E-26 ID:SGTC_575|Compound:k072-0246|FD-Score:4.99|P-value:1.33E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-4.15|P-value:5.07E-5 ID:SGTC_716|Compound:1683-5115|FD-Score:3.29|P-value:9.57E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:4.56|P-value:8.63E-6 ID:SGTC_743|Compound:1275-0778|FD-Score:3.47|P-value:5.39E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:6.38|P-value:9.78E-10 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.97|P-value:9.23E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.20|P-value:4.26E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:10.80|P-value:1.80E-24 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.97|P-value:1.00E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:15.30|P-value:2.86E-47 ID:SGTC_1165|Compound:k072-0275|FD-Score:5.93|P-value:1.18E-8 ID:SGTC_1176|Compound:0848-0131|FD-Score:4.02|P-value:7.62E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.88|P-value:1.25E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.43|P-value:6.81E-4 ID:SGTC_1354|Compound:1498-1681|FD-Score:-3.94|P-value:1.13E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:-4.84|P-value:2.96E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:4.61|P-value:6.96E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.35|P-value:7.92E-4 ID:SGTC_1712|Compound:st032288|FD-Score:-5.57|P-value:8.97E-8 ID:SGTC_1738|Compound:st035555|FD-Score:-3.37|P-value:8.20E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.72|P-value:1.92E-13 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.89|P-value:1.22E-4 ID:SGTC_1836|Compound:st055642|FD-Score:3.29|P-value:9.45E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.65|P-value:2.84E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.81|P-value:1.82E-4 ID:SGTC_1895|Compound:st058434|FD-Score:3.74|P-value:2.10E-4 ID:SGTC_1899|Compound:st063254|FD-Score:-3.90|P-value:1.31E-4 ID:SGTC_1900|Compound:st060200|FD-Score:-3.50|P-value:5.29E-4 ID:SGTC_1977|Compound:st070720|FD-Score:3.46|P-value:5.60E-4 ID:SGTC_2112|Compound:5488546|FD-Score:3.54|P-value:4.18E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-3.48|P-value:5.64E-4 ID:SGTC_2132|Compound:5317594|FD-Score:3.58|P-value:3.67E-4 ID:SGTC_2322|Compound:7413319|FD-Score:7.40|P-value:1.65E-12 ID:SGTC_2343|Compound:7990716|FD-Score:4.68|P-value:5.23E-6 ID:SGTC_2347|Compound:9049783|FD-Score:3.67|P-value:2.73E-4 ID:SGTC_2348|Compound:9022543|FD-Score:-3.91|P-value:1.25E-4 ID:SGTC_2351|Compound:9026858|FD-Score:-4.27|P-value:3.23E-5 ID:SGTC_2472|Compound:5377652|FD-Score:4.26|P-value:2.97E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.96|P-value:9.55E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:11.50|P-value:2.12E-27 ID:SGTC_2725|Compound:haloperidol|FD-Score:5.27|P-value:3.51E-7 ID:SGTC_2823|Compound:7987624|FD-Score:5.63|P-value:5.87E-8 ID:SGTC_2824|Compound:7998404|FD-Score:4.97|P-value:1.40E-6 ID:SGTC_2966|Compound:9084041|FD-Score:-3.89|P-value:1.35E-4 ID:SGTC_2993|Compound:9054257|FD-Score:5.70|P-value:4.09E-8 ID:SGTC_3008|Compound:9078912|FD-Score:4.02|P-value:7.48E-5 ID:SGTC_3066|Compound:9117245|FD-Score:3.30|P-value:9.31E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.52|P-value:4.52E-4 ID:SGTC_3126|Compound:9127922|FD-Score:3.46|P-value:5.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.48|P-value:5.61E-4

Top fitness defect scores for YER084W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_103 0844-0104 15.70 51.8 µM 7.00E-50 ERAD & cell cycle 8 3.52E-56
2 SGTC_1161 k007-0610 15.30 110.0 µM 2.86E-47 ERAD & cell cycle 5 3.18E-53
3 SGTC_373 0844-0104 13.50 25.9 µM 4.92E-37 ERAD & cell cycle 4 1.23E-41
4 SGTC_384 k007-0144 12.70 5.2 µM 4.46E-33 ERAD & cell cycle 6 3.71E-37
5 SGTC_2582 agaric acid 11.50 100.0 µM 2.12E-27 redox potentiating 44 9.83E-31
6 SGTC_568 1193-0097 11.20 7.5 µM 3.95E-26 ERAD & cell cycle 17 2.70E-29
7 SGTC_1026 k007-1105 10.80 30.6 µM 1.80E-24 ERAD & cell cycle 10 2.03E-27
8 SGTC_1750 st081859 7.72 2.4 µM 1.92E-13 endomembrane recycling 75 5.94E-15
9 SGTC_86 0417-1630 7.47 471.9 µM 1.07E-12 ubiquinone biosynthesis & proteasome 64 4.12E-14
10 SGTC_2322 7413319 7.40 38.2 µM 1.65E-12 ERAD & cell cycle 42 6.77E-14
11 SGTC_81 0411-0046 6.80 10.0 µM 7.60E-11 7 5.10E-12
12 SGTC_352 k048-0007 6.51 5.1 µM 4.60E-10 ERAD & cell cycle 29 3.88E-11
13 SGTC_805 3852-0218 6.38 479.0 µM 9.78E-10 ERAD & cell cycle 21 9.10E-11
14 SGTC_453 enantio-paf c16 5.98 10.0 µM 8.88E-9 51 1.10E-9
15 SGTC_1165 k072-0275 5.93 30.3 µM 1.18E-8 10 1.50E-9
16 SGTC_2993 9054257 5.70 71.4 µM 4.09E-8 fatty acid desaturase (OLE1) 20 6.13E-9
17 SGTC_2823 7987624 5.63 58.4 µM 5.87E-8 5 9.21E-9
18 SGTC_2725 haloperidol 5.27 53.2 µM 3.51E-7 plasma membrane duress 24 6.91E-8
19 SGTC_575 k072-0246 4.99 11.9 µM 1.33E-6 10 3.09E-7
20 SGTC_2824 7998404 4.97 52.0 µM 1.40E-6 15 3.28E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.559 1.12E-274 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.517 1.28E-228 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.513 3.34E-225 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.490 1.42E-202 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.465 2.83E-179 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.454 1.60E-170 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.425 3.58E-147 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.423 6.48E-146 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.393 3.49E-124 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.390 5.81E-122 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
0.369 8.42E-109 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.363 2.44E-105 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.351 5.59E-98 YFR008W FAR7 hom Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress
0.341 6.95E-92 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.322 1.62E-81 YLR065C ENV10 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene