YER086W / ILV1

Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YER086W / ILV1

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:5.54|P-value:2.28E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:4.90|P-value:4.24E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.84|P-value:2.81E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:4.74|P-value:8.19E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:20.10|P-value:4.93E-76 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.42|P-value:6.87E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.88|P-value:4.61E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:3.44|P-value:9.43E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:7.24|P-value:1.93E-11 ID:SGTC_81|Compound:0411-0046|FD-Score:6.29|P-value:5.03E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:4.65|P-value:1.20E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:10.90|P-value:9.33E-24 ID:SGTC_87|Compound:0100-0052|FD-Score:15.10|P-value:6.42E-44 ID:SGTC_90|Compound:0870-0863|FD-Score:15.10|P-value:1.29E-43 ID:SGTC_91|Compound:0417-1751|FD-Score:4.53|P-value:1.99E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:1.47E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:13.30|P-value:1.76E-34 ID:SGTC_126|Compound:0417-1624|FD-Score:4.73|P-value:8.82E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:9.47|P-value:2.45E-18 ID:SGTC_129|Compound:0088-0017|FD-Score:8.96|P-value:1.32E-16 ID:SGTC_137|Compound:0438-0332|FD-Score:11.80|P-value:1.77E-27 ID:SGTC_142|Compound:0335-0849|FD-Score:8.43|P-value:6.53E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:6.94|P-value:1.25E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:5.66|P-value:1.27E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:4.44|P-value:2.81E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.34|P-value:1.07E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.89|P-value:4.01E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.82|P-value:5.95E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:4.86|P-value:4.95E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:1.44E-25 ID:SGTC_253|Compound:dyclonine|FD-Score:8.46|P-value:5.30E-15 ID:SGTC_274|Compound:sirtinol|FD-Score:11.30|P-value:1.87E-25 ID:SGTC_313|Compound:3474-0040|FD-Score:3.61|P-value:5.41E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:13.80|P-value:3.51E-37 ID:SGTC_337|Compound:1315-0038|FD-Score:4.45|P-value:2.67E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.77|P-value:3.18E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.98|P-value:1.55E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.83|P-value:2.31E-10 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.57|P-value:1.68E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.58|P-value:5.95E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.40|P-value:3.21E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.35|P-value:3.96E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.85|P-value:2.41E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:6.70|P-value:4.88E-10 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.42|P-value:6.87E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:10.20|P-value:3.65E-21 ID:SGTC_797|Compound:k781-0471|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:7.39|P-value:7.54E-12 ID:SGTC_852|Compound:0418-0143|FD-Score:18.00|P-value:1.07E-61 ID:SGTC_860|Compound:0443-0016|FD-Score:4.13|P-value:9.05E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:6.50|P-value:1.52E-9 ID:SGTC_984|Compound:1492-0255|FD-Score:9.88|P-value:8.07E-20 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.12|P-value:1.65E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:7.57|P-value:2.35E-12 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.02|P-value:2.04E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.97|P-value:1.02E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.47|P-value:1.54E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.11|P-value:9.71E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.07|P-value:1.11E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.65|P-value:1.18E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:6.99|P-value:9.10E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.50|P-value:7.73E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.76|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:8.09E-45 ID:SGTC_1656|Compound:st012921|FD-Score:5.84|P-value:5.30E-8 ID:SGTC_1696|Compound:st025591|FD-Score:6.94|P-value:1.20E-10 ID:SGTC_1699|Compound:st031318|FD-Score:5.68|P-value:1.18E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-3.55|P-value:4.48E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.76|P-value:7.69E-6 ID:SGTC_1725|Compound:st036284|FD-Score:-3.44|P-value:6.45E-4 ID:SGTC_1726|Compound:st035556|FD-Score:15.50|P-value:4.44E-46 ID:SGTC_1772|Compound:st048439|FD-Score:3.69|P-value:4.14E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.89|P-value:2.15E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.04|P-value:2.29E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.65|P-value:3.21E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.41|P-value:3.19E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.77|P-value:3.22E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.54|P-value:6.81E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.44|P-value:9.49E-4 ID:SGTC_2132|Compound:5317594|FD-Score:7.48|P-value:4.19E-12 ID:SGTC_2172|Compound:5754775|FD-Score:3.66|P-value:4.66E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.43|P-value:9.61E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.53|P-value:4.71E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.13|P-value:5.63E-5 ID:SGTC_2430|Compound:5571206|FD-Score:5.80|P-value:6.41E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.61|P-value:5.48E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.89|P-value:2.11E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.20|P-value:3.63E-21 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.64|P-value:1.41E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.26|P-value:1.74E-11 ID:SGTC_2851|Compound:9015922|FD-Score:4.00|P-value:1.46E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.66|P-value:1.15E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.85|P-value:5.13E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:11.30|P-value:1.44E-25 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.27|P-value:5.58E-9 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.30|P-value:4.75E-9 ID:SGTC_3177|Compound:9107506|FD-Score:4.38|P-value:3.58E-5 ID:SGTC_46|Compound:0329-0187a|FD-Score:5.54|P-value:2.28E-7 ID:SGTC_55|Compound:0767-0285|FD-Score:4.90|P-value:4.24E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.84|P-value:2.81E-8 ID:SGTC_59|Compound:0330-0160|FD-Score:4.74|P-value:8.19E-6 ID:SGTC_64|Compound:000l-0018|FD-Score:20.10|P-value:4.93E-76 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.42|P-value:6.87E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:4.88|P-value:4.61E-6 ID:SGTC_78|Compound:0336-0123|FD-Score:3.44|P-value:9.43E-4 ID:SGTC_79|Compound:0052-0007|FD-Score:7.24|P-value:1.93E-11 ID:SGTC_81|Compound:0411-0046|FD-Score:6.29|P-value:5.03E-9 ID:SGTC_84|Compound:0443-0269|FD-Score:4.65|P-value:1.20E-5 ID:SGTC_86|Compound:0417-1630|FD-Score:10.90|P-value:9.33E-24 ID:SGTC_87|Compound:0100-0052|FD-Score:15.10|P-value:6.42E-44 ID:SGTC_90|Compound:0870-0863|FD-Score:15.10|P-value:1.29E-43 ID:SGTC_91|Compound:0417-1751|FD-Score:4.53|P-value:1.99E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.87|P-value:1.47E-4 ID:SGTC_107|Compound:0358-0022|FD-Score:13.30|P-value:1.76E-34 ID:SGTC_126|Compound:0417-1624|FD-Score:4.73|P-value:8.82E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:9.47|P-value:2.45E-18 ID:SGTC_129|Compound:0088-0017|FD-Score:8.96|P-value:1.32E-16 ID:SGTC_137|Compound:0438-0332|FD-Score:11.80|P-value:1.77E-27 ID:SGTC_142|Compound:0335-0849|FD-Score:8.43|P-value:6.53E-15 ID:SGTC_158|Compound:k038-0087|FD-Score:6.94|P-value:1.25E-10 ID:SGTC_163|Compound:1327-0036|FD-Score:5.66|P-value:1.27E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:4.44|P-value:2.81E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:7.34|P-value:1.07E-11 ID:SGTC_216|Compound:k038-0035|FD-Score:5.89|P-value:4.01E-8 ID:SGTC_232|Compound:clozapine|FD-Score:4.82|P-value:5.95E-6 ID:SGTC_235|Compound:0330-0087|FD-Score:4.86|P-value:4.95E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:11.30|P-value:1.44E-25 ID:SGTC_253|Compound:dyclonine|FD-Score:8.46|P-value:5.30E-15 ID:SGTC_274|Compound:sirtinol|FD-Score:11.30|P-value:1.87E-25 ID:SGTC_313|Compound:3474-0040|FD-Score:3.61|P-value:5.41E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:13.80|P-value:3.51E-37 ID:SGTC_337|Compound:1315-0038|FD-Score:4.45|P-value:2.67E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.77|P-value:3.18E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:3.98|P-value:1.55E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:6.83|P-value:2.31E-10 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.57|P-value:1.68E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.58|P-value:5.95E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:4.40|P-value:3.21E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:4.04|P-value:1.26E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:4.35|P-value:3.96E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:3.85|P-value:2.41E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:6.70|P-value:4.88E-10 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.42|P-value:6.87E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:10.20|P-value:3.65E-21 ID:SGTC_797|Compound:k781-0471|FD-Score:4.09|P-value:1.04E-4 ID:SGTC_845|Compound:0330-0138|FD-Score:7.39|P-value:7.54E-12 ID:SGTC_852|Compound:0418-0143|FD-Score:18.00|P-value:1.07E-61 ID:SGTC_860|Compound:0443-0016|FD-Score:4.13|P-value:9.05E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:6.50|P-value:1.52E-9 ID:SGTC_984|Compound:1492-0255|FD-Score:9.88|P-value:8.07E-20 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.12|P-value:1.65E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:7.57|P-value:2.35E-12 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.02|P-value:2.04E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.97|P-value:1.02E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:-4.47|P-value:1.54E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.11|P-value:9.71E-5 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.07|P-value:1.11E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.65|P-value:1.18E-5 ID:SGTC_1313|Compound:1220-0047|FD-Score:6.99|P-value:9.10E-11 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.50|P-value:7.73E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.76|P-value:3.37E-4 ID:SGTC_1635|Compound:st007035|FD-Score:15.30|P-value:8.09E-45 ID:SGTC_1656|Compound:st012921|FD-Score:5.84|P-value:5.30E-8 ID:SGTC_1696|Compound:st025591|FD-Score:6.94|P-value:1.20E-10 ID:SGTC_1699|Compound:st031318|FD-Score:5.68|P-value:1.18E-7 ID:SGTC_1713|Compound:st033146|FD-Score:-3.55|P-value:4.48E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.76|P-value:7.69E-6 ID:SGTC_1725|Compound:st036284|FD-Score:-3.44|P-value:6.45E-4 ID:SGTC_1726|Compound:st035556|FD-Score:15.50|P-value:4.44E-46 ID:SGTC_1772|Compound:st048439|FD-Score:3.69|P-value:4.14E-4 ID:SGTC_1837|Compound:st055472|FD-Score:3.89|P-value:2.15E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.04|P-value:2.29E-6 ID:SGTC_1915|Compound:st067105|FD-Score:-3.65|P-value:3.21E-4 ID:SGTC_1989|Compound:st071868|FD-Score:4.41|P-value:3.19E-5 ID:SGTC_1996|Compound:st072960|FD-Score:3.77|P-value:3.22E-4 ID:SGTC_2090|Compound:5301565|FD-Score:3.54|P-value:6.81E-4 ID:SGTC_2111|Compound:5486399|FD-Score:3.44|P-value:9.49E-4 ID:SGTC_2132|Compound:5317594|FD-Score:7.48|P-value:4.19E-12 ID:SGTC_2172|Compound:5754775|FD-Score:3.66|P-value:4.66E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.43|P-value:9.61E-4 ID:SGTC_2343|Compound:7990716|FD-Score:-3.53|P-value:4.71E-4 ID:SGTC_2357|Compound:9067248|FD-Score:-4.13|P-value:5.63E-5 ID:SGTC_2430|Compound:5571206|FD-Score:5.80|P-value:6.41E-8 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:3.61|P-value:5.48E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.89|P-value:2.11E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:10.20|P-value:3.63E-21 ID:SGTC_2659|Compound:sanguinarine|FD-Score:5.64|P-value:1.41E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.26|P-value:1.74E-11 ID:SGTC_2851|Compound:9015922|FD-Score:4.00|P-value:1.46E-4 ID:SGTC_2891|Compound:9063876|FD-Score:4.66|P-value:1.15E-5 ID:SGTC_2921|Compound:7974240|FD-Score:4.85|P-value:5.13E-6 ID:SGTC_3059|Compound:1327-0034|FD-Score:11.30|P-value:1.44E-25 ID:SGTC_3060|Compound:1327-0027|FD-Score:6.27|P-value:5.58E-9 ID:SGTC_3063|Compound:1327-0034|FD-Score:6.30|P-value:4.75E-9 ID:SGTC_3177|Compound:9107506|FD-Score:4.38|P-value:3.58E-5

Top fitness defect scores for YER086W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 20.10 272.1 µM 4.93E-76 ubiquinone biosynthesis & proteasome 10 6.74E-90
2 SGTC_852 0418-0143 18.00 439.0 µM 1.07E-61 calcium & mitochondrial duress 4 6.28E-73
3 SGTC_1726 st035556 15.50 14.6 µM 4.44E-46 2 1.96E-54
4 SGTC_1635 st007035 15.30 42.4 µM 8.09E-45 38 6.09E-53
5 SGTC_87 0100-0052 15.10 35.5 µM 6.42E-44 1 7.09E-52
6 SGTC_90 0870-0863 15.10 4.6 µM 1.29E-43 4 1.62E-51
7 SGTC_315 k915-0449 13.80 187.0 µM 3.51E-37 5 6.78E-44
8 SGTC_107 0358-0022 13.30 2.7 µM 1.76E-34 SWF1 & branched chain AA biosynthesis 5 1.07E-40
9 SGTC_137 0438-0332 11.80 85.4 µM 1.77E-27 ubiquinone biosynthesis & proteasome 20 2.12E-32
10 SGTC_3059 1327-0034 11.30 3.0 µM 1.44E-25 8 3.89E-30
11 SGTC_236 1509-0011 11.30 5.3 µM 1.44E-25 164 3.90E-30
12 SGTC_274 sirtinol 11.30 40.1 µM 1.87E-25 1 5.33E-30
13 SGTC_86 0417-1630 10.90 471.9 µM 9.33E-24 ubiquinone biosynthesis & proteasome 32 5.48E-28
14 SGTC_2651 1327-0036 10.20 5.0 µM 3.63E-21 23 6.43E-25
15 SGTC_796 1234-0020 10.20 70.7 µM 3.65E-21 SWF1 & branched chain AA biosynthesis 2 6.47E-25
16 SGTC_984 1492-0255 9.88 2.9 µM 8.07E-20 SWF1 & branched chain AA biosynthesis 3 2.55E-23
17 SGTC_127 0180-0333 9.47 59.1 µM 2.45E-18 mitochondrial response to ROS 2 1.46E-21
18 SGTC_129 0088-0017 8.96 176.6 µM 1.32E-16 12 1.65E-19
19 SGTC_253 dyclonine 8.46 31.2 µM 5.30E-15 amide catabolism 5 1.31E-17
20 SGTC_142 0335-0849 8.43 62.7 µM 6.53E-15 ubiquinone biosynthesis & proteasome 41 1.68E-17

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.391 4.01E-123 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.375 2.05E-112 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.372 1.30E-110 YOR125C CAT5 hom Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation
0.358 6.82E-102 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.354 2.98E-99 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.349 5.04E-97 YNR041C COQ2 hom Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis
0.338 1.19E-90 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.334 2.41E-88 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.333 1.08E-87 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.326 8.54E-84 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.306 1.67E-73 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.300 7.40E-71 YDR148C KGD2 hom Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
0.300 7.40E-71 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.300 1.68E-70 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.287 1.52E-64 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)