YER090W / TRP2

Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YER090W / TRP2

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:9.89|P-value:3.70E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:12.50|P-value:5.87E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.35|P-value:9.59E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:8.51|P-value:6.21E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:7.72|P-value:2.63E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:7.60|P-value:3.23E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:8.77|P-value:3.78E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:7.57|P-value:3.40E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:9.05|P-value:2.16E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:8.57|P-value:5.51E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:7.43|P-value:4.29E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:9.25|P-value:1.44E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:8.00|P-value:1.59E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.35|P-value:8.45E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:7.05|P-value:7.98E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.94|P-value:1.77E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-6.74|P-value:5.12E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.85|P-value:2.08E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:7.20|P-value:6.27E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.61|P-value:5.10E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:8.64|P-value:4.86E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:8.23|P-value:1.04E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:9.08|P-value:2.03E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:10.60|P-value:7.62E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:8.55|P-value:5.77E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:7.22|P-value:6.03E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:16.30|P-value:4.57E-14 ID:SGTC_1019|Compound:4262-0212|FD-Score:12.10|P-value:1.93E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.71|P-value:4.19E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:14.50|P-value:1.41E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:7.31|P-value:5.27E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.51|P-value:6.18E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.10|P-value:2.11E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:8.85|P-value:3.19E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:13.20|P-value:9.28E-10 ID:SGTC_1101|Compound:ebselen|FD-Score:8.44|P-value:7.07E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:-6.34|P-value:9.85E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:15.90|P-value:1.38E-13 ID:SGTC_1114|Compound:scopoletin|FD-Score:11.10|P-value:2.35E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:6.95|P-value:9.32E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:10.10|P-value:2.47E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.97|P-value:9.08E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:7.30|P-value:5.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:7.58|P-value:3.34E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:7.34|P-value:4.94E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:8.80|P-value:3.52E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-8.17|P-value:3.88E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:22.10|P-value:1.16E-24 ID:SGTC_1457|Compound:k015-0032|FD-Score:18.50|P-value:7.82E-18 ID:SGTC_1482|Compound:3346-2049|FD-Score:9.23|P-value:1.48E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:7.59|P-value:3.28E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.29|P-value:5.44E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:11.60|P-value:6.81E-8 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:9.46|P-value:9.33E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:7.10|P-value:7.43E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:11.70|P-value:5.03E-8 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:17.40|P-value:7.02E-16 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.15|P-value:6.83E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.94|P-value:1.77E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:8.38|P-value:7.89E-5 ID:SGTC_1603|Compound:st002045|FD-Score:18.80|P-value:2.54E-18 ID:SGTC_1608|Compound:st001473|FD-Score:7.72|P-value:2.60E-4 ID:SGTC_1617|Compound:st002906|FD-Score:20.10|P-value:1.25E-20 ID:SGTC_1636|Compound:st007707|FD-Score:11.50|P-value:7.90E-8 ID:SGTC_1649|Compound:st011737|FD-Score:6.97|P-value:9.13E-4 ID:SGTC_1671|Compound:st016596|FD-Score:7.14|P-value:6.86E-4 ID:SGTC_1673|Compound:st016611|FD-Score:9.34|P-value:1.19E-5 ID:SGTC_1697|Compound:st025554|FD-Score:11.10|P-value:2.41E-7 ID:SGTC_1699|Compound:st031318|FD-Score:12.00|P-value:2.38E-8 ID:SGTC_1710|Compound:st031758|FD-Score:8.52|P-value:6.03E-5 ID:SGTC_1715|Compound:st032160|FD-Score:10.70|P-value:6.48E-7 ID:SGTC_1717|Compound:st033143|FD-Score:11.50|P-value:8.67E-8 ID:SGTC_1720|Compound:st037298|FD-Score:8.72|P-value:4.14E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-6.66|P-value:5.91E-4 ID:SGTC_1752|Compound:st044819|FD-Score:7.03|P-value:8.24E-4 ID:SGTC_1757|Compound:st041620|FD-Score:7.70|P-value:2.71E-4 ID:SGTC_1764|Compound:st044502|FD-Score:7.17|P-value:6.57E-4 ID:SGTC_1778|Compound:st046819|FD-Score:9.27|P-value:1.38E-5 ID:SGTC_1797|Compound:st048695|FD-Score:11.60|P-value:6.27E-8 ID:SGTC_1835|Compound:st008666|FD-Score:8.48|P-value:6.53E-5 ID:SGTC_1847|Compound:st056231|FD-Score:8.99|P-value:2.42E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-7.28|P-value:2.04E-4 ID:SGTC_1868|Compound:st057644|FD-Score:7.39|P-value:4.59E-4 ID:SGTC_1881|Compound:5652484|FD-Score:11.20|P-value:1.66E-7 ID:SGTC_1882|Compound:5615643|FD-Score:10.20|P-value:2.03E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:13.10|P-value:9.71E-10 ID:SGTC_1909|Compound:st060837|FD-Score:12.40|P-value:8.88E-9 ID:SGTC_1952|Compound:st077036|FD-Score:12.30|P-value:9.86E-9 ID:SGTC_1953|Compound:st076800|FD-Score:6.92|P-value:9.75E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:7.38|P-value:4.68E-4 ID:SGTC_1957|Compound:st077035|FD-Score:7.33|P-value:5.02E-4 ID:SGTC_1975|Compound:st070967|FD-Score:14.00|P-value:6.69E-11 ID:SGTC_1999|Compound:st074831|FD-Score:15.00|P-value:2.91E-12 ID:SGTC_2036|Compound:5160441|FD-Score:11.70|P-value:5.43E-8 ID:SGTC_2038|Compound:4100038|FD-Score:12.40|P-value:7.02E-9 ID:SGTC_2064|Compound:5220758|FD-Score:6.93|P-value:9.64E-4 ID:SGTC_2090|Compound:5301565|FD-Score:13.20|P-value:7.43E-10 ID:SGTC_2093|Compound:5331342|FD-Score:20.90|P-value:2.71E-22 ID:SGTC_2094|Compound:5332512|FD-Score:8.54|P-value:5.88E-5 ID:SGTC_2137|Compound:5261020|FD-Score:18.30|P-value:1.74E-17 ID:SGTC_2148|Compound:5546263|FD-Score:9.46|P-value:9.26E-6 ID:SGTC_2152|Compound:5568786|FD-Score:9.78|P-value:4.69E-6 ID:SGTC_2162|Compound:5663267|FD-Score:8.38|P-value:7.95E-5 ID:SGTC_2163|Compound:5671233|FD-Score:12.90|P-value:2.03E-9 ID:SGTC_2175|Compound:5807670|FD-Score:7.20|P-value:6.27E-4 ID:SGTC_2194|Compound:5927483|FD-Score:7.60|P-value:3.18E-4 ID:SGTC_2197|Compound:6588183|FD-Score:9.15|P-value:1.77E-5 ID:SGTC_2203|Compound:7227154|FD-Score:10.30|P-value:1.59E-6 ID:SGTC_2231|Compound:micatex|FD-Score:9.90|P-value:3.64E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:11.00|P-value:3.00E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.67|P-value:5.90E-6 ID:SGTC_2254|Compound:7938975|FD-Score:21.60|P-value:1.41E-23 ID:SGTC_2255|Compound:7941087|FD-Score:15.80|P-value:1.91E-13 ID:SGTC_2296|Compound:7971656|FD-Score:13.70|P-value:1.82E-10 ID:SGTC_2299|Compound:7976368|FD-Score:11.20|P-value:1.97E-7 ID:SGTC_2301|Compound:7769476|FD-Score:10.70|P-value:6.49E-7 ID:SGTC_2304|Compound:7443016|FD-Score:13.40|P-value:4.28E-10 ID:SGTC_2312|Compound:7706453|FD-Score:13.70|P-value:1.83E-10 ID:SGTC_2384|Compound:9036245|FD-Score:9.78|P-value:4.66E-6 ID:SGTC_2403|Compound:6032726|FD-Score:8.50|P-value:6.33E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.60|P-value:6.96E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:14.40|P-value:2.27E-11 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:12.90|P-value:1.82E-9 ID:SGTC_2455|Compound:5377712|FD-Score:7.50|P-value:3.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:13.20|P-value:8.32E-10 ID:SGTC_2468|Compound:5987765|FD-Score:11.80|P-value:3.81E-8 ID:SGTC_2472|Compound:5377652|FD-Score:20.00|P-value:1.43E-20 ID:SGTC_2488|Compound:5268135|FD-Score:11.80|P-value:3.46E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:13.10|P-value:1.24E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:7.87|P-value:1.99E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:9.86|P-value:3.94E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:8.40|P-value:7.60E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:12.40|P-value:8.64E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:12.50|P-value:5.53E-9 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:11.80|P-value:3.83E-8 ID:SGTC_2683|Compound:piperine|FD-Score:7.99|P-value:1.61E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:9.65|P-value:6.20E-6 ID:SGTC_2699|Compound:st077704|FD-Score:8.18|P-value:1.15E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:15.80|P-value:2.03E-13 ID:SGTC_2733|Compound:amorolfine|FD-Score:10.30|P-value:1.37E-6 ID:SGTC_2735|Compound:sertaconazole|FD-Score:9.53|P-value:8.07E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.29|P-value:5.39E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:16.60|P-value:1.11E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:22.40|P-value:2.45E-25 ID:SGTC_2776|Compound:terbinafine|FD-Score:13.70|P-value:2.19E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:12.10|P-value:1.67E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:19.60|P-value:1.20E-19 ID:SGTC_2816|Compound:7982706|FD-Score:6.91|P-value:9.92E-4 ID:SGTC_2939|Compound:9044578|FD-Score:13.60|P-value:2.55E-10 ID:SGTC_2993|Compound:9054257|FD-Score:7.00|P-value:8.59E-4 ID:SGTC_3018|Compound:9082602|FD-Score:14.60|P-value:1.13E-11 ID:SGTC_3152|Compound:9099253|FD-Score:7.88|P-value:1.98E-4 ID:SGTC_3308|Compound:9128332|FD-Score:14.10|P-value:5.46E-11 ID:SGTC_50|Compound:0929-0078|FD-Score:9.89|P-value:3.70E-6 ID:SGTC_51|Compound:1013-0126|FD-Score:12.50|P-value:5.87E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-6.35|P-value:9.59E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:8.51|P-value:6.21E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:7.72|P-value:2.63E-4 ID:SGTC_179|Compound:1273-0063|FD-Score:7.60|P-value:3.23E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:8.77|P-value:3.78E-5 ID:SGTC_407|Compound:eburnamonine|FD-Score:7.57|P-value:3.40E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:9.05|P-value:2.16E-5 ID:SGTC_410|Compound:α-linolenic acid|FD-Score:8.57|P-value:5.51E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:7.43|P-value:4.29E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:9.25|P-value:1.44E-5 ID:SGTC_507|Compound:nimesulide|FD-Score:8.00|P-value:1.59E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:8.35|P-value:8.45E-5 ID:SGTC_636|Compound:0kpi-0074|FD-Score:7.05|P-value:7.98E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:7.94|P-value:1.77E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:-6.74|P-value:5.12E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:7.85|P-value:2.08E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:7.20|P-value:6.27E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:8.61|P-value:5.10E-5 ID:SGTC_820|Compound:1582-0060|FD-Score:8.64|P-value:4.86E-5 ID:SGTC_823|Compound:0417-1665|FD-Score:8.23|P-value:1.04E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:9.08|P-value:2.03E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:10.60|P-value:7.62E-7 ID:SGTC_933|Compound:2914-0560|FD-Score:8.55|P-value:5.77E-5 ID:SGTC_960|Compound:1222-0186|FD-Score:7.22|P-value:6.03E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:16.30|P-value:4.57E-14 ID:SGTC_1019|Compound:4262-0212|FD-Score:12.10|P-value:1.93E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:8.71|P-value:4.19E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:14.50|P-value:1.41E-11 ID:SGTC_1042|Compound:0350-0096|FD-Score:7.31|P-value:5.27E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:8.51|P-value:6.18E-5 ID:SGTC_1072|Compound:oxiconazole|FD-Score:10.10|P-value:2.11E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:8.85|P-value:3.19E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:13.20|P-value:9.28E-10 ID:SGTC_1101|Compound:ebselen|FD-Score:8.44|P-value:7.07E-5 ID:SGTC_1103|Compound:duloxetine|FD-Score:-6.34|P-value:9.85E-4 ID:SGTC_1104|Compound:tacrolimus|FD-Score:15.90|P-value:1.38E-13 ID:SGTC_1114|Compound:scopoletin|FD-Score:11.10|P-value:2.35E-7 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:6.95|P-value:9.32E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:10.10|P-value:2.47E-6 ID:SGTC_1160|Compound:4092-0570|FD-Score:6.97|P-value:9.08E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:7.30|P-value:5.28E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:7.58|P-value:3.34E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:7.34|P-value:4.94E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:8.80|P-value:3.52E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-8.17|P-value:3.88E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:22.10|P-value:1.16E-24 ID:SGTC_1457|Compound:k015-0032|FD-Score:18.50|P-value:7.82E-18 ID:SGTC_1482|Compound:3346-2049|FD-Score:9.23|P-value:1.48E-5 ID:SGTC_1496|Compound:4469-0713|FD-Score:7.59|P-value:3.28E-4 ID:SGTC_1510|Compound:1123-0200|FD-Score:7.29|P-value:5.44E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:11.60|P-value:6.81E-8 ID:SGTC_1541|Compound:2',3',6-trimethoxyflavone|FD-Score:9.46|P-value:9.33E-6 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:7.10|P-value:7.43E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:11.70|P-value:5.03E-8 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:17.40|P-value:7.02E-16 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:7.15|P-value:6.83E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:8.16|P-value:1.19E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:7.94|P-value:1.77E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:8.38|P-value:7.89E-5 ID:SGTC_1603|Compound:st002045|FD-Score:18.80|P-value:2.54E-18 ID:SGTC_1608|Compound:st001473|FD-Score:7.72|P-value:2.60E-4 ID:SGTC_1617|Compound:st002906|FD-Score:20.10|P-value:1.25E-20 ID:SGTC_1636|Compound:st007707|FD-Score:11.50|P-value:7.90E-8 ID:SGTC_1649|Compound:st011737|FD-Score:6.97|P-value:9.13E-4 ID:SGTC_1671|Compound:st016596|FD-Score:7.14|P-value:6.86E-4 ID:SGTC_1673|Compound:st016611|FD-Score:9.34|P-value:1.19E-5 ID:SGTC_1697|Compound:st025554|FD-Score:11.10|P-value:2.41E-7 ID:SGTC_1699|Compound:st031318|FD-Score:12.00|P-value:2.38E-8 ID:SGTC_1710|Compound:st031758|FD-Score:8.52|P-value:6.03E-5 ID:SGTC_1715|Compound:st032160|FD-Score:10.70|P-value:6.48E-7 ID:SGTC_1717|Compound:st033143|FD-Score:11.50|P-value:8.67E-8 ID:SGTC_1720|Compound:st037298|FD-Score:8.72|P-value:4.14E-5 ID:SGTC_1728|Compound:st035614|FD-Score:-6.66|P-value:5.91E-4 ID:SGTC_1752|Compound:st044819|FD-Score:7.03|P-value:8.24E-4 ID:SGTC_1757|Compound:st041620|FD-Score:7.70|P-value:2.71E-4 ID:SGTC_1764|Compound:st044502|FD-Score:7.17|P-value:6.57E-4 ID:SGTC_1778|Compound:st046819|FD-Score:9.27|P-value:1.38E-5 ID:SGTC_1797|Compound:st048695|FD-Score:11.60|P-value:6.27E-8 ID:SGTC_1835|Compound:st008666|FD-Score:8.48|P-value:6.53E-5 ID:SGTC_1847|Compound:st056231|FD-Score:8.99|P-value:2.42E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-7.28|P-value:2.04E-4 ID:SGTC_1868|Compound:st057644|FD-Score:7.39|P-value:4.59E-4 ID:SGTC_1881|Compound:5652484|FD-Score:11.20|P-value:1.66E-7 ID:SGTC_1882|Compound:5615643|FD-Score:10.20|P-value:2.03E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:13.10|P-value:9.71E-10 ID:SGTC_1909|Compound:st060837|FD-Score:12.40|P-value:8.88E-9 ID:SGTC_1952|Compound:st077036|FD-Score:12.30|P-value:9.86E-9 ID:SGTC_1953|Compound:st076800|FD-Score:6.92|P-value:9.75E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:7.38|P-value:4.68E-4 ID:SGTC_1957|Compound:st077035|FD-Score:7.33|P-value:5.02E-4 ID:SGTC_1975|Compound:st070967|FD-Score:14.00|P-value:6.69E-11 ID:SGTC_1999|Compound:st074831|FD-Score:15.00|P-value:2.91E-12 ID:SGTC_2036|Compound:5160441|FD-Score:11.70|P-value:5.43E-8 ID:SGTC_2038|Compound:4100038|FD-Score:12.40|P-value:7.02E-9 ID:SGTC_2064|Compound:5220758|FD-Score:6.93|P-value:9.64E-4 ID:SGTC_2090|Compound:5301565|FD-Score:13.20|P-value:7.43E-10 ID:SGTC_2093|Compound:5331342|FD-Score:20.90|P-value:2.71E-22 ID:SGTC_2094|Compound:5332512|FD-Score:8.54|P-value:5.88E-5 ID:SGTC_2137|Compound:5261020|FD-Score:18.30|P-value:1.74E-17 ID:SGTC_2148|Compound:5546263|FD-Score:9.46|P-value:9.26E-6 ID:SGTC_2152|Compound:5568786|FD-Score:9.78|P-value:4.69E-6 ID:SGTC_2162|Compound:5663267|FD-Score:8.38|P-value:7.95E-5 ID:SGTC_2163|Compound:5671233|FD-Score:12.90|P-value:2.03E-9 ID:SGTC_2175|Compound:5807670|FD-Score:7.20|P-value:6.27E-4 ID:SGTC_2194|Compound:5927483|FD-Score:7.60|P-value:3.18E-4 ID:SGTC_2197|Compound:6588183|FD-Score:9.15|P-value:1.77E-5 ID:SGTC_2203|Compound:7227154|FD-Score:10.30|P-value:1.59E-6 ID:SGTC_2231|Compound:micatex|FD-Score:9.90|P-value:3.64E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:11.00|P-value:3.00E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:9.67|P-value:5.90E-6 ID:SGTC_2254|Compound:7938975|FD-Score:21.60|P-value:1.41E-23 ID:SGTC_2255|Compound:7941087|FD-Score:15.80|P-value:1.91E-13 ID:SGTC_2296|Compound:7971656|FD-Score:13.70|P-value:1.82E-10 ID:SGTC_2299|Compound:7976368|FD-Score:11.20|P-value:1.97E-7 ID:SGTC_2301|Compound:7769476|FD-Score:10.70|P-value:6.49E-7 ID:SGTC_2304|Compound:7443016|FD-Score:13.40|P-value:4.28E-10 ID:SGTC_2312|Compound:7706453|FD-Score:13.70|P-value:1.83E-10 ID:SGTC_2384|Compound:9036245|FD-Score:9.78|P-value:4.66E-6 ID:SGTC_2403|Compound:6032726|FD-Score:8.50|P-value:6.33E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:9.60|P-value:6.96E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:14.40|P-value:2.27E-11 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:12.90|P-value:1.82E-9 ID:SGTC_2455|Compound:5377712|FD-Score:7.50|P-value:3.83E-4 ID:SGTC_2461|Compound:5755302|FD-Score:13.20|P-value:8.32E-10 ID:SGTC_2468|Compound:5987765|FD-Score:11.80|P-value:3.81E-8 ID:SGTC_2472|Compound:5377652|FD-Score:20.00|P-value:1.43E-20 ID:SGTC_2488|Compound:5268135|FD-Score:11.80|P-value:3.46E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:13.10|P-value:1.24E-9 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:7.87|P-value:1.99E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:9.86|P-value:3.94E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:8.40|P-value:7.60E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:12.40|P-value:8.64E-9 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:12.50|P-value:5.53E-9 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:11.80|P-value:3.83E-8 ID:SGTC_2683|Compound:piperine|FD-Score:7.99|P-value:1.61E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:9.65|P-value:6.20E-6 ID:SGTC_2699|Compound:st077704|FD-Score:8.18|P-value:1.15E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:15.80|P-value:2.03E-13 ID:SGTC_2733|Compound:amorolfine|FD-Score:10.30|P-value:1.37E-6 ID:SGTC_2735|Compound:sertaconazole|FD-Score:9.53|P-value:8.07E-6 ID:SGTC_2741|Compound:miltefosine|FD-Score:7.29|P-value:5.39E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:16.60|P-value:1.11E-14 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:22.40|P-value:2.45E-25 ID:SGTC_2776|Compound:terbinafine|FD-Score:13.70|P-value:2.19E-10 ID:SGTC_2777|Compound:climbazole|FD-Score:12.10|P-value:1.67E-8 ID:SGTC_2778|Compound:tioconazole|FD-Score:19.60|P-value:1.20E-19 ID:SGTC_2816|Compound:7982706|FD-Score:6.91|P-value:9.92E-4 ID:SGTC_2939|Compound:9044578|FD-Score:13.60|P-value:2.55E-10 ID:SGTC_2993|Compound:9054257|FD-Score:7.00|P-value:8.59E-4 ID:SGTC_3018|Compound:9082602|FD-Score:14.60|P-value:1.13E-11 ID:SGTC_3152|Compound:9099253|FD-Score:7.88|P-value:1.98E-4 ID:SGTC_3308|Compound:9128332|FD-Score:14.10|P-value:5.46E-11

Top fitness defect scores for YER090W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2758 dehydroepiandrosterone 22.40 69.3 µM 2.45E-25 4 1.17E-111
2 SGTC_1455 4262-0120 22.10 131.0 µM 1.16E-24 plasma membrane duress 1 1.52E-108
3 SGTC_2254 7938975 21.60 95.2 µM 1.41E-23 3 1.56E-103
4 SGTC_2093 5331342 20.90 194.4 µM 2.71E-22 2 1.28E-97
5 SGTC_1617 st002906 20.10 78.0 µM 1.25E-20 2 6.12E-90
6 SGTC_2472 5377652 20.00 49.4 µM 1.43E-20 TRP & mitochondrial translation 2 1.14E-89
7 SGTC_2778 tioconazole 19.60 65.1 nM 1.20E-19 ergosterol depletion effects on membrane 2 2.05E-85
8 SGTC_1603 st002045 18.80 67.8 µM 2.54E-18 TSC3-RPN4 3 2.70E-79
9 SGTC_1457 k015-0032 18.50 57.3 µM 7.82E-18 1 4.77E-77
10 SGTC_2137 5261020 18.30 140.0 µM 1.74E-17 2 1.91E-75
11 SGTC_1572 epiandrosterone 17.40 68.9 µM 7.02E-16 1 4.84E-68
12 SGTC_2752 diclazuril 16.60 33.1 µM 1.11E-14 6 1.60E-62
13 SGTC_1011 4112-3381 16.30 17.4 µM 4.57E-14 1 1.10E-59
14 SGTC_1104 tacrolimus 15.90 29.8 µM 1.38E-13 3 1.78E-57
15 SGTC_2255 7941087 15.80 197.4 µM 1.91E-13 1 7.94E-57
16 SGTC_2725 haloperidol 15.80 53.2 µM 2.03E-13 plasma membrane duress 3 1.07E-56
17 SGTC_1999 st074831 15.00 12.5 µM 2.91E-12 plasma membrane duress 3 2.23E-51
18 SGTC_3018 9082602 14.60 49.5 µM 1.13E-11 4 1.14E-48
19 SGTC_1041 0206-0046 14.50 107.0 µM 1.41E-11 1 3.18E-48
20 SGTC_2409 alverine citrate 14.40 64.0 µM 2.27E-11 3 2.87E-47

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.768 0 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.704 0 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.678 0 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.655 0 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.550 7.73E-264 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.539 2.13E-251 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.489 1.64E-200 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.487 7.12E-198 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.450 1.39E-165 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.448 3.20E-164 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.389 1.91E-120 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.344 4.54E-93 YFR009W GCN20 hom Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
0.336 1.14E-88 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.220 7.74E-38 YIR023W DAL81 hom Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
0.176 1.64E-24 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments