YER105C / NUP157

Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER105C / NUP157

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:-2.70|P-value:8.34E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:2.79|P-value:4.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.38|P-value:3.28E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.33|P-value:5.08E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.40|P-value:2.87E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.39|P-value:3.70E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.08|P-value:1.33E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.33|P-value:4.91E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.04|P-value:1.38E-9 ID:SGTC_250|Compound:brefeldin a|FD-Score:-2.91|P-value:3.37E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.19|P-value:9.59E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.49|P-value:1.89E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.49|P-value:1.82E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.75|P-value:6.63E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.64|P-value:8.51E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:2.99|P-value:1.99E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.13|P-value:1.08E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-2.84|P-value:4.51E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-2.92|P-value:3.24E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.97|P-value:2.19E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.92|P-value:2.73E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.21|P-value:7.29E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.12|P-value:5.52E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.42|P-value:2.63E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.14|P-value:1.03E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.91|P-value:2.89E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.14|P-value:1.01E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.68|P-value:7.61E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:2.99|P-value:2.02E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.08|P-value:1.34E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.51|P-value:1.69E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.11|P-value:1.07E-9 ID:SGTC_1676|Compound:st018489|FD-Score:6.88|P-value:2.52E-16 ID:SGTC_1677|Compound:st019204|FD-Score:2.96|P-value:2.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.21|P-value:3.24E-7 ID:SGTC_1694|Compound:st024011|FD-Score:2.62|P-value:9.49E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-2.79|P-value:5.76E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.28|P-value:6.49E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.04|P-value:1.62E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.96|P-value:1.47E-6 ID:SGTC_2146|Compound:5545642|FD-Score:-3.16|P-value:1.13E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.07|P-value:1.40E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.75|P-value:4.62E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.12|P-value:1.13E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.77|P-value:4.24E-6 ID:SGTC_2331|Compound:7980721|FD-Score:2.96|P-value:2.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.79|P-value:5.60E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-2.75|P-value:6.78E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.07|P-value:1.37E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.80|P-value:4.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.95|P-value:1.50E-6 ID:SGTC_2851|Compound:9015922|FD-Score:4.11|P-value:6.10E-7 ID:SGTC_2858|Compound:9025781|FD-Score:3.17|P-value:8.68E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-2.84|P-value:4.52E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:-2.70|P-value:8.34E-4 ID:SGTC_74|Compound:000s-0487|FD-Score:2.79|P-value:4.84E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.38|P-value:3.28E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:-3.33|P-value:5.08E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:3.40|P-value:2.87E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.39|P-value:3.70E-5 ID:SGTC_198|Compound:3454-2873|FD-Score:3.08|P-value:1.33E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:-3.33|P-value:4.91E-5 ID:SGTC_234|Compound:nsc-17383|FD-Score:5.04|P-value:1.38E-9 ID:SGTC_250|Compound:brefeldin a|FD-Score:-2.91|P-value:3.37E-4 ID:SGTC_353|Compound:1988-1175|FD-Score:-3.19|P-value:9.59E-5 ID:SGTC_373|Compound:0844-0104|FD-Score:3.49|P-value:1.89E-5 ID:SGTC_377|Compound:3970-0964|FD-Score:3.49|P-value:1.82E-5 ID:SGTC_494|Compound:Boc-Gly-Val-Val-CHO|FD-Score:-2.75|P-value:6.63E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:3.64|P-value:8.51E-6 ID:SGTC_683|Compound:panaxydol|FD-Score:2.99|P-value:1.99E-4 ID:SGTC_699|Compound:0375-0592|FD-Score:3.13|P-value:1.08E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-2.84|P-value:4.51E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:-2.92|P-value:3.24E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:2.97|P-value:2.19E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:2.92|P-value:2.73E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.21|P-value:7.29E-5 ID:SGTC_1022|Compound:4477-0945|FD-Score:4.12|P-value:5.52E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:3.42|P-value:2.63E-5 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.14|P-value:1.03E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:2.91|P-value:2.89E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.14|P-value:1.01E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.68|P-value:7.61E-4 ID:SGTC_1489|Compound:4065-0444|FD-Score:2.99|P-value:2.02E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.08|P-value:1.34E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.51|P-value:1.69E-5 ID:SGTC_1673|Compound:st016611|FD-Score:-5.11|P-value:1.07E-9 ID:SGTC_1676|Compound:st018489|FD-Score:6.88|P-value:2.52E-16 ID:SGTC_1677|Compound:st019204|FD-Score:2.96|P-value:2.32E-4 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.21|P-value:3.24E-7 ID:SGTC_1694|Compound:st024011|FD-Score:2.62|P-value:9.49E-4 ID:SGTC_1706|Compound:st031321|FD-Score:-2.79|P-value:5.76E-4 ID:SGTC_1724|Compound:st037281|FD-Score:-3.28|P-value:6.49E-5 ID:SGTC_1930|Compound:st074634|FD-Score:3.04|P-value:1.62E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.96|P-value:1.47E-6 ID:SGTC_2146|Compound:5545642|FD-Score:-3.16|P-value:1.13E-4 ID:SGTC_2151|Compound:5563267|FD-Score:3.07|P-value:1.40E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.75|P-value:4.62E-6 ID:SGTC_2302|Compound:7771753|FD-Score:3.12|P-value:1.13E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.77|P-value:4.24E-6 ID:SGTC_2331|Compound:7980721|FD-Score:2.96|P-value:2.26E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:-2.79|P-value:5.60E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-2.75|P-value:6.78E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.07|P-value:1.37E-4 ID:SGTC_2585|Compound:alliin|FD-Score:2.80|P-value:4.60E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.95|P-value:1.50E-6 ID:SGTC_2851|Compound:9015922|FD-Score:4.11|P-value:6.10E-7 ID:SGTC_2858|Compound:9025781|FD-Score:3.17|P-value:8.68E-5 ID:SGTC_3006|Compound:9075424|FD-Score:-2.84|P-value:4.52E-4

Top fitness defect scores for YER105C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1676 st018489 6.88 23.4 µM 2.52E-16 60S ribosome export 3 2.99E-12
2 SGTC_234 nsc-17383 5.04 10.7 µM 1.38E-9 ERG2 14 2.36E-7
3 SGTC_1681 tripelennamine 4.21 100.0 µM 3.24E-7 16 1.26E-5
4 SGTC_1022 4477-0945 4.12 21.3 µM 5.52E-7 20 1.86E-5
5 SGTC_2851 9015922 4.11 71.4 µM 6.10E-7 33 2.00E-5
6 SGTC_1967 st070177 3.96 51.4 µM 1.47E-6 12 3.79E-5
7 SGTC_2757 clomiphene 3.95 4.2 µM 1.50E-6 fatty acid desaturase (OLE1) 42 3.84E-5
8 SGTC_2309 7664088 3.77 163.9 µM 4.24E-6 40 8.24E-5
9 SGTC_2167 5876490 3.75 200.0 µM 4.62E-6 39 8.77E-5
10 SGTC_561 1550-0330 3.64 72.9 µM 8.51E-6 13 1.37E-4
11 SGTC_1523 st012844 3.51 44.7 µM 1.69E-5 60S ribosome export 39 2.26E-4
12 SGTC_377 3970-0964 3.49 33.1 µM 1.82E-5 66 2.39E-4
13 SGTC_373 0844-0104 3.49 25.9 µM 1.89E-5 ERAD & cell cycle 70 2.46E-4
14 SGTC_1216 1165-0504 3.42 9.7 µM 2.63E-5 26 3.13E-4
15 SGTC_164 4100-3994 3.40 89.6 µM 2.87E-5 55 3.34E-4
16 SGTC_99 0109-0120 3.38 622.8 µM 3.28E-5 28 3.68E-4
17 SGTC_1008 4106-0037 3.21 6.0 µM 7.29E-5 PDR1 39 6.61E-4
18 SGTC_2858 9025781 3.17 9.0 µM 8.68E-5 sphingolipid biosynthesis & PDR1 152 7.52E-4
19 SGTC_1317 1273-0028 3.14 910.0 nM 1.01E-4 azole & statin 86 8.41E-4
20 SGTC_1280 0880-0253 3.14 10.1 µM 1.03E-4 44 8.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.33E-14 YEL011W GLC3 hom Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.106 6.82E-10 YKL070W_p YKL070W_p hom Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.101 5.35E-9 YLR211C_p YLR211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron
0.099 7.97E-9 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.097 1.59E-8 YDR385W EFT2 hom Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
0.093 6.87E-8 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.092 9.13E-8 YMR276W DSK2 hom Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress
0.091 1.26E-7 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.089 2.43E-7 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.089 2.40E-7 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.088 3.61E-7 YIL088C AVT7 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.087 3.93E-7 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.085 8.55E-7 YMR083W ADH3 hom Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
0.082 2.17E-6 YPL153C RAD53 het Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
0.079 4.51E-6 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion