HIPHOP chemogenomics database

YER114C / BOI2

Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YER114C / BOI2

Click on Significant Values for Screen Details

Top fitness defect scores for YER114C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1749	st037932	7.23	54.2 µM	6.12E-12		2	2.47E-13
2	SGTC_138	0850-0259	6.07	40.9 µM	6.87E-9	cell wall	103	6.51E-10
3	SGTC_2634	4'-methoxyflavone	5.41	100.0 µM	2.18E-7		9	3.17E-8
4	SGTC_2381	9035592	5.34	200.0 µM	3.07E-7		4	4.66E-8
5	SGTC_2831	7999036	5.29	19.5 µM	3.84E-7		14	5.98E-8
6	SGTC_1885	st057546	5.22	99.9 µM	5.53E-7		4	9.01E-8
7	SGTC_1581	himbacine	5.11	57.9 µM	9.39E-7	Golgi	30	1.63E-7
8	SGTC_116	0155-0182	5.02	31.8 µM	1.42E-6	mitochondrial response to ROS	41	2.60E-7
9	SGTC_1467	k284-1082	4.88	293.0 µM	2.71E-6		6	5.38E-7
10	SGTC_1679	4130-1276	4.80	6.7 µM	3.87E-6	Golgi	41	8.03E-7
11	SGTC_2482	5981709	4.77	142.7 µM	4.42E-6	PDR1	24	9.34E-7
12	SGTC_2981	9013952	4.57	39.0 µM	1.03E-5		29	2.41E-6
13	SGTC_324	1315-0088	4.44	19.6 µM	1.76E-5	RSC & ERG11	6	4.43E-6
14	SGTC_817	1391-0715	4.37	46.0 µM	2.39E-5		12	6.24E-6
15	SGTC_1509	1326-1131	4.33	80.0 µM	2.85E-5		7	7.58E-6
16	SGTC_2313	7726885	4.29	200.0 µM	3.31E-5	RPP1 & pyrimidine depletion	26	8.99E-6
17	SGTC_1844	rapamycin	4.06	4.0 nM	8.07E-5		154	2.45E-5
18	SGTC_3117	9124945	4.02	49.5 µM	9.40E-5		4	2.91E-5
19	SGTC_530	4358-1714	3.99	28.0 µM	1.04E-4		45	3.27E-5
20	SGTC_552	k242-0005	3.89	476.0 µM	1.53E-4		16	5.03E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.124	5.70E-13	YMR079W	SEC14	het	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.122	1.15E-12	YMR182W-A_p	YMR182W-A_p	hom	Putative protein of unknown function
0.115	2.89E-11	YLL043W	FPS1	hom	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.112	8.67E-11	YPR033C	HTS1	het	Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.109	2.52E-10	YBR233W	PBP2	hom	RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress
0.107	5.77E-10	YLR150W	STM1	hom	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.102	2.67E-9	YML121W	GTR1	hom	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.098	1.27E-8	YDR016C	DAD1	het	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
0.098	1.51E-8	YJR111C_p	YJR111C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.096	2.56E-8	YPR095C	SYT1	hom	Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain
0.093	7.59E-8	YHR075C	PPE1	hom	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
0.091	1.49E-7	YDL041W_d	YDL041W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
0.090	1.79E-7	YOL094C	RFC4	het	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.089	2.61E-7	YDR351W	SBE2	hom	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.088	2.98E-7	YDR481C	PHO8	hom	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN