HIPHOP chemogenomics database
YER121W_p 
Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER121W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.129 | 6.28E-14 | YLL042C | ATG10 | hom | Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy |
| 0.126 | 2.43E-13 | YJR082C | EAF6 | hom | Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 |
| 0.124 | 5.30E-13 | YFR045W_p | YFR045W_p | hom | Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white |
| 0.123 | 1.07E-12 | YHL045W_d | YHL045W_d | hom | Putative protein of unknown function; not an essential gene |
| 0.115 | 2.80E-11 | YOL132W | GAS4 | hom | 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall |
| 0.111 | 1.37E-10 | YMR290C | HAS1 | het | ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles |
| 0.108 | 3.30E-10 | YOR271C_p | FSF1_p | hom | Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis |
| 0.104 | 1.72E-9 | YDR304C | CPR5 | hom | Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER |
| 0.103 | 1.99E-9 | YGL114W_p | YGL114W_p | hom | Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters |
| 0.101 | 5.23E-9 | YGR049W | SCM4 | hom | Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation |
| 0.099 | 9.11E-9 | YML025C | YML6 | het | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins |
| 0.098 | 1.51E-8 | YNL154C | YCK2 | hom | Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication |
| 0.096 | 2.51E-8 | YIL009W | FAA3 | hom | Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery |
| 0.094 | 4.57E-8 | YGL224C | SDT1 | hom | Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives |
| 0.094 | 5.53E-8 | YDR394W | RPT3 | het | One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B |