YER121W_p

Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy

Zygosity: Homozygous strain
fixedexpanded
Profile for YER121W / YER121W

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:3.28|P-value:9.83E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.62|P-value:2.24E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.30|P-value:2.37E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.40|P-value:4.83E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.96|P-value:8.86E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.40|P-value:6.56E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.03|P-value:5.88E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:3.97|P-value:8.65E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.38|P-value:5.19E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.82|P-value:1.52E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.26|P-value:2.75E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.30|P-value:2.38E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.78|P-value:1.75E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.68|P-value:4.61E-6 ID:SGTC_1852|Compound:st056254|FD-Score:4.25|P-value:2.91E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.54|P-value:4.16E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.30|P-value:9.13E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:10.60|P-value:2.96E-24 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-5.74|P-value:1.55E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.87|P-value:1.26E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-5.35|P-value:1.23E-7 ID:SGTC_2692|Compound:st077426|FD-Score:5.67|P-value:3.68E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.52|P-value:4.44E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.66|P-value:2.70E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.47|P-value:3.77E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.28|P-value:9.83E-4 ID:SGTC_251|Compound:melphalan|FD-Score:-3.62|P-value:2.24E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.30|P-value:2.37E-5 ID:SGTC_561|Compound:1550-0330|FD-Score:-3.40|P-value:4.83E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.96|P-value:8.86E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.40|P-value:6.56E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.03|P-value:5.88E-7 ID:SGTC_914|Compound:3820-6779|FD-Score:3.97|P-value:8.65E-5 ID:SGTC_1058|Compound:3448-5425|FD-Score:-3.38|P-value:5.19E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.82|P-value:1.52E-4 ID:SGTC_1116|Compound:jasmonic acid|FD-Score:4.32|P-value:2.19E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.26|P-value:2.75E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.30|P-value:2.38E-5 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.78|P-value:1.75E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.34|P-value:8.04E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.45|P-value:5.60E-4 ID:SGTC_1676|Compound:st018489|FD-Score:4.68|P-value:4.61E-6 ID:SGTC_1852|Compound:st056254|FD-Score:4.25|P-value:2.91E-5 ID:SGTC_2388|Compound:9080168|FD-Score:3.54|P-value:4.16E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.30|P-value:9.13E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:10.60|P-value:2.96E-24 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:3.54|P-value:4.14E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-5.74|P-value:1.55E-8 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.87|P-value:1.26E-6 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-5.35|P-value:1.23E-7 ID:SGTC_2692|Compound:st077426|FD-Score:5.67|P-value:3.68E-8 ID:SGTC_2815|Compound:7968870|FD-Score:3.52|P-value:4.44E-4 ID:SGTC_2929|Compound:9013348|FD-Score:3.66|P-value:2.70E-4 ID:SGTC_3034|Compound:9090421|FD-Score:-3.47|P-value:3.77E-4

Top fitness defect scores for YER121W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2409 alverine citrate 10.60 64.0 µM 2.96E-24 5 1.60E-26
2 SGTC_2692 st077426 5.67 47.7 µM 3.68E-8 6 7.13E-9
3 SGTC_1676 st018489 4.68 23.4 µM 4.61E-6 60S ribosome export 17 1.43E-6
4 SGTC_1116 jasmonic acid 4.32 1.6 µM 2.19E-5 14 7.95E-6
5 SGTC_459 nigericin 4.30 15.3 µM 2.37E-5 54 8.64E-6
6 SGTC_1223 0764-0573 4.30 147.0 µM 2.38E-5 13 8.71E-6
7 SGTC_1212 0520-0165 4.26 585.0 µM 2.75E-5 19 1.02E-5
8 SGTC_1852 st056254 4.25 31.4 µM 2.91E-5 7 1.08E-5
9 SGTC_914 3820-6779 3.97 408.0 µM 8.65E-5 22 3.59E-5
10 SGTC_665 3914-0008 3.96 307.0 µM 8.86E-5 20 3.68E-5
11 SGTC_1080 nisoldipine 3.82 24.4 µM 1.52E-4 TSC3-RPN4 30 6.65E-5
12 SGTC_1288 0973-0013 3.78 65.5 µM 1.75E-4 20 7.77E-5
13 SGTC_2929 9013348 3.66 24.6 µM 2.70E-4 32 1.25E-4
14 SGTC_2562 3',7'-dimethoxyflavone 3.54 64.9 µM 4.14E-4 49 2.00E-4
15 SGTC_2388 9080168 3.54 200.0 µM 4.16E-4 7 2.01E-4
16 SGTC_2815 7968870 3.52 71.4 µM 4.44E-4 40 2.16E-4
17 SGTC_1503 4585-0012 3.45 61.3 µM 5.60E-4 31 2.79E-4
18 SGTC_684 1140-0066 3.40 328.0 µM 6.56E-4 Golgi 55 3.32E-4
19 SGTC_1316 1272-0050 3.34 65.9 µM 8.04E-4 24 4.15E-4
20 SGTC_2399 5884133 3.30 200.0 µM 9.13E-4 cell wall signaling 108 4.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.28E-14 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.126 2.43E-13 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.124 5.30E-13 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.123 1.07E-12 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.115 2.80E-11 YOL132W GAS4 hom 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
0.111 1.37E-10 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.108 3.30E-10 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.104 1.72E-9 YDR304C CPR5 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
0.103 1.99E-9 YGL114W_p YGL114W_p hom Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
0.101 5.23E-9 YGR049W SCM4 hom Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation
0.099 9.11E-9 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.098 1.51E-8 YNL154C YCK2 hom Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; YCK2 has a paralog, YCK1, that arose from the whole genome duplication
0.096 2.51E-8 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.094 4.57E-8 YGL224C SDT1 hom Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
0.094 5.53E-8 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B