YER133W / GLC7

Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER133W / GLC7

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:20.70|P-value:1.08E-31 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.04|P-value:3.54E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.33|P-value:1.75E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:8.66|P-value:5.04E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:9.14|P-value:1.23E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:8.73|P-value:4.18E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:6.40|P-value:1.51E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.62|P-value:7.64E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.67|P-value:6.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:9.93|P-value:1.04E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:30.20|P-value:3.11E-65 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:32.30|P-value:1.88E-74 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.34|P-value:1.25E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.97|P-value:4.22E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-5.56|P-value:8.59E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.11|P-value:2.80E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:13.00|P-value:9.18E-14 ID:SGTC_363|Compound:0455-0021|FD-Score:11.10|P-value:1.62E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.40|P-value:5.94E-11 ID:SGTC_379|Compound:3970-0972|FD-Score:5.81|P-value:5.17E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:15.70|P-value:3.78E-19 ID:SGTC_422|Compound:cantharidin|FD-Score:15.60|P-value:7.60E-19 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-7.64|P-value:8.12E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.56|P-value:1.08E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.94|P-value:3.97E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.58|P-value:8.24E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:19.60|P-value:8.53E-29 ID:SGTC_500|Compound:h-89|FD-Score:8.75|P-value:3.95E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:5.94|P-value:4.00E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:11.00|P-value:2.58E-10 ID:SGTC_566|Compound:0958-0068|FD-Score:5.53|P-value:9.07E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:9.70|P-value:2.17E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:8.09|P-value:2.47E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:8.78|P-value:3.66E-7 ID:SGTC_600|Compound:1495-0418|FD-Score:6.37|P-value:1.62E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:8.88|P-value:2.73E-7 ID:SGTC_609|Compound:0986-0026|FD-Score:7.98|P-value:3.29E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:6.74|P-value:7.04E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:10.80|P-value:5.17E-10 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.15|P-value:2.70E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.00|P-value:3.54E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.93|P-value:3.84E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:18.80|P-value:1.43E-26 ID:SGTC_916|Compound:4466-0038|FD-Score:8.99|P-value:1.96E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:6.41|P-value:1.48E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.60|P-value:9.70E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:7.02|P-value:3.69E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:13.80|P-value:2.73E-15 ID:SGTC_1067|Compound:clotrimazole|FD-Score:11.60|P-value:3.49E-11 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.50|P-value:1.21E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.78|P-value:5.59E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.19|P-value:2.45E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.03|P-value:3.32E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.64|P-value:8.98E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.75|P-value:5.88E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.63|P-value:9.03E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:9.37|P-value:6.15E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:8.99|P-value:1.93E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.10|P-value:9.84E-18 ID:SGTC_1621|Compound:st003705|FD-Score:8.79|P-value:3.51E-7 ID:SGTC_1622|Compound:st003707|FD-Score:9.36|P-value:6.35E-8 ID:SGTC_1625|Compound:st003711|FD-Score:16.30|P-value:1.92E-20 ID:SGTC_1627|Compound:st003713|FD-Score:18.10|P-value:7.59E-25 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.10|P-value:5.33E-9 ID:SGTC_1712|Compound:st032288|FD-Score:7.66|P-value:7.72E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:6.82|P-value:5.93E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.85|P-value:2.98E-7 ID:SGTC_1766|Compound:st045414|FD-Score:10.00|P-value:7.40E-9 ID:SGTC_1800|Compound:st050079|FD-Score:6.56|P-value:1.08E-4 ID:SGTC_1812|Compound:st052057|FD-Score:8.50|P-value:7.97E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.57|P-value:6.59E-7 ID:SGTC_1959|Compound:st077091|FD-Score:11.90|P-value:8.84E-12 ID:SGTC_1979|Compound:st071809|FD-Score:6.03|P-value:3.30E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.92|P-value:4.19E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.63|P-value:7.42E-4 ID:SGTC_1989|Compound:st071868|FD-Score:5.96|P-value:3.88E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-6.05|P-value:3.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:23.80|P-value:2.06E-41 ID:SGTC_2054|Compound:5233173|FD-Score:-6.34|P-value:1.74E-4 ID:SGTC_2057|Compound:5236571|FD-Score:16.40|P-value:9.18E-21 ID:SGTC_2156|Compound:5649887|FD-Score:9.39|P-value:5.86E-8 ID:SGTC_2183|Compound:6420625|FD-Score:7.99|P-value:3.27E-6 ID:SGTC_2192|Compound:5915882|FD-Score:8.63|P-value:5.59E-7 ID:SGTC_2268|Compound:7933382|FD-Score:7.32|P-value:1.78E-5 ID:SGTC_2270|Compound:7924575|FD-Score:8.34|P-value:1.26E-6 ID:SGTC_2275|Compound:7947463|FD-Score:-6.16|P-value:2.56E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.78|P-value:5.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.41|P-value:5.46E-8 ID:SGTC_2342|Compound:7990637|FD-Score:12.90|P-value:1.64E-13 ID:SGTC_2344|Compound:7990960|FD-Score:-6.86|P-value:5.45E-5 ID:SGTC_2363|Compound:9053361|FD-Score:8.34|P-value:1.26E-6 ID:SGTC_2367|Compound:9070478|FD-Score:8.37|P-value:1.16E-6 ID:SGTC_2374|Compound:9071832|FD-Score:-5.91|P-value:4.26E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-6.24|P-value:2.13E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-9.01|P-value:1.84E-7 ID:SGTC_2401|Compound:5128683|FD-Score:7.59|P-value:9.11E-6 ID:SGTC_2436|Compound:5633522|FD-Score:7.72|P-value:6.57E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:22.00|P-value:1.01E-35 ID:SGTC_2507|Compound:purpurin|FD-Score:8.60|P-value:6.03E-7 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:16.20|P-value:3.44E-20 ID:SGTC_2515|Compound:chrysin|FD-Score:7.14|P-value:2.77E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:10.70|P-value:7.48E-10 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.85|P-value:5.50E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:12.80|P-value:2.24E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:34.60|P-value:3.41E-85 ID:SGTC_2651|Compound:1327-0036|FD-Score:-7.77|P-value:5.84E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.46|P-value:4.71E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:6.54|P-value:1.11E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.86|P-value:4.66E-4 ID:SGTC_2791|Compound:5663188|FD-Score:7.35|P-value:1.68E-5 ID:SGTC_2800|Compound:7887935|FD-Score:6.18|P-value:2.44E-4 ID:SGTC_2810|Compound:7959871|FD-Score:6.13|P-value:2.68E-4 ID:SGTC_2954|Compound:9074818|FD-Score:7.13|P-value:2.85E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.68|P-value:4.80E-7 ID:SGTC_2970|Compound:9090938|FD-Score:5.70|P-value:6.44E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.87|P-value:4.62E-4 ID:SGTC_3004|Compound:9076122|FD-Score:6.71|P-value:7.65E-5 ID:SGTC_3020|Compound:9089140|FD-Score:5.65|P-value:7.09E-4 ID:SGTC_3039|Compound:9090270|FD-Score:6.71|P-value:7.68E-5 ID:SGTC_3098|Compound:9119039|FD-Score:6.22|P-value:2.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:5.48|P-value:9.92E-4 ID:SGTC_3219|Compound:9131112|FD-Score:8.37|P-value:1.16E-6 ID:SGTC_3225|Compound:9130819|FD-Score:6.20|P-value:2.31E-4 ID:SGTC_3232|Compound:9132874|FD-Score:11.20|P-value:1.53E-10 ID:SGTC_3270|Compound:9137563|FD-Score:6.08|P-value:2.98E-4 ID:SGTC_3350|Compound:9150499|FD-Score:6.93|P-value:4.56E-5 ID:SGTC_3351|Compound:9150312|FD-Score:9.82|P-value:1.52E-8 ID:SGTC_39|Compound:0986-0283|FD-Score:20.70|P-value:1.08E-31 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:7.04|P-value:3.54E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:6.33|P-value:1.75E-4 ID:SGTC_122|Compound:0236-0016|FD-Score:8.66|P-value:5.04E-7 ID:SGTC_123|Compound:0083-0120|FD-Score:9.14|P-value:1.23E-7 ID:SGTC_138|Compound:0850-0259|FD-Score:8.73|P-value:4.18E-7 ID:SGTC_176|Compound:1486-1328|FD-Score:6.40|P-value:1.51E-4 ID:SGTC_187|Compound:1488-2104|FD-Score:5.62|P-value:7.64E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:5.67|P-value:6.84E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:9.93|P-value:1.04E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:30.20|P-value:3.11E-65 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:32.30|P-value:1.88E-74 ID:SGTC_255|Compound:tunicamycin|FD-Score:8.34|P-value:1.25E-6 ID:SGTC_256|Compound:clotrimazole|FD-Score:6.97|P-value:4.22E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-5.56|P-value:8.59E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.11|P-value:2.80E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:13.00|P-value:9.18E-14 ID:SGTC_363|Compound:0455-0021|FD-Score:11.10|P-value:1.62E-10 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.40|P-value:5.94E-11 ID:SGTC_379|Compound:3970-0972|FD-Score:5.81|P-value:5.17E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:15.70|P-value:3.78E-19 ID:SGTC_422|Compound:cantharidin|FD-Score:15.60|P-value:7.60E-19 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-7.64|P-value:8.12E-6 ID:SGTC_435|Compound:c-PAF|FD-Score:-6.56|P-value:1.08E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:-5.94|P-value:3.97E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:5.58|P-value:8.24E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:19.60|P-value:8.53E-29 ID:SGTC_500|Compound:h-89|FD-Score:8.75|P-value:3.95E-7 ID:SGTC_525|Compound:k781-2675|FD-Score:5.94|P-value:4.00E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:11.00|P-value:2.58E-10 ID:SGTC_566|Compound:0958-0068|FD-Score:5.53|P-value:9.07E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:9.70|P-value:2.17E-8 ID:SGTC_582|Compound:0987-0078|FD-Score:8.09|P-value:2.47E-6 ID:SGTC_583|Compound:1488-1091|FD-Score:8.78|P-value:3.66E-7 ID:SGTC_600|Compound:1495-0418|FD-Score:6.37|P-value:1.62E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:8.88|P-value:2.73E-7 ID:SGTC_609|Compound:0986-0026|FD-Score:7.98|P-value:3.29E-6 ID:SGTC_614|Compound:0462-0418|FD-Score:6.74|P-value:7.04E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:10.80|P-value:5.17E-10 ID:SGTC_682|Compound:0kpi-0099|FD-Score:7.15|P-value:2.70E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:6.00|P-value:3.54E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-7.93|P-value:3.84E-6 ID:SGTC_863|Compound:0466-0191|FD-Score:18.80|P-value:1.43E-26 ID:SGTC_916|Compound:4466-0038|FD-Score:8.99|P-value:1.96E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:6.41|P-value:1.48E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:6.60|P-value:9.70E-5 ID:SGTC_1055|Compound:3448-0672|FD-Score:7.02|P-value:3.69E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:13.80|P-value:2.73E-15 ID:SGTC_1067|Compound:clotrimazole|FD-Score:11.60|P-value:3.49E-11 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.50|P-value:1.21E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-5.78|P-value:5.59E-4 ID:SGTC_1162|Compound:k048-0130|FD-Score:7.19|P-value:2.45E-5 ID:SGTC_1194|Compound:1488-0194|FD-Score:6.03|P-value:3.32E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:6.64|P-value:8.98E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.75|P-value:5.88E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:6.63|P-value:9.03E-5 ID:SGTC_1385|Compound:3091-4834|FD-Score:9.37|P-value:6.15E-8 ID:SGTC_1399|Compound:3562-5772|FD-Score:8.99|P-value:1.93E-7 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:15.10|P-value:9.84E-18 ID:SGTC_1621|Compound:st003705|FD-Score:8.79|P-value:3.51E-7 ID:SGTC_1622|Compound:st003707|FD-Score:9.36|P-value:6.35E-8 ID:SGTC_1625|Compound:st003711|FD-Score:16.30|P-value:1.92E-20 ID:SGTC_1627|Compound:st003713|FD-Score:18.10|P-value:7.59E-25 ID:SGTC_1679|Compound:4130-1276|FD-Score:10.10|P-value:5.33E-9 ID:SGTC_1712|Compound:st032288|FD-Score:7.66|P-value:7.72E-6 ID:SGTC_1718|Compound:roemerine|FD-Score:6.82|P-value:5.93E-5 ID:SGTC_1745|Compound:st081495|FD-Score:8.85|P-value:2.98E-7 ID:SGTC_1766|Compound:st045414|FD-Score:10.00|P-value:7.40E-9 ID:SGTC_1800|Compound:st050079|FD-Score:6.56|P-value:1.08E-4 ID:SGTC_1812|Compound:st052057|FD-Score:8.50|P-value:7.97E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.57|P-value:6.59E-7 ID:SGTC_1959|Compound:st077091|FD-Score:11.90|P-value:8.84E-12 ID:SGTC_1979|Compound:st071809|FD-Score:6.03|P-value:3.30E-4 ID:SGTC_1980|Compound:st071811|FD-Score:5.92|P-value:4.19E-4 ID:SGTC_1983|Compound:st071813|FD-Score:5.63|P-value:7.42E-4 ID:SGTC_1989|Compound:st071868|FD-Score:5.96|P-value:3.88E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-6.05|P-value:3.20E-4 ID:SGTC_2021|Compound:4019055|FD-Score:23.80|P-value:2.06E-41 ID:SGTC_2054|Compound:5233173|FD-Score:-6.34|P-value:1.74E-4 ID:SGTC_2057|Compound:5236571|FD-Score:16.40|P-value:9.18E-21 ID:SGTC_2156|Compound:5649887|FD-Score:9.39|P-value:5.86E-8 ID:SGTC_2183|Compound:6420625|FD-Score:7.99|P-value:3.27E-6 ID:SGTC_2192|Compound:5915882|FD-Score:8.63|P-value:5.59E-7 ID:SGTC_2268|Compound:7933382|FD-Score:7.32|P-value:1.78E-5 ID:SGTC_2270|Compound:7924575|FD-Score:8.34|P-value:1.26E-6 ID:SGTC_2275|Compound:7947463|FD-Score:-6.16|P-value:2.56E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.78|P-value:5.49E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.41|P-value:5.46E-8 ID:SGTC_2342|Compound:7990637|FD-Score:12.90|P-value:1.64E-13 ID:SGTC_2344|Compound:7990960|FD-Score:-6.86|P-value:5.45E-5 ID:SGTC_2363|Compound:9053361|FD-Score:8.34|P-value:1.26E-6 ID:SGTC_2367|Compound:9070478|FD-Score:8.37|P-value:1.16E-6 ID:SGTC_2374|Compound:9071832|FD-Score:-5.91|P-value:4.26E-4 ID:SGTC_2389|Compound:9091542|FD-Score:-6.24|P-value:2.13E-4 ID:SGTC_2396|Compound:5342950|FD-Score:-9.01|P-value:1.84E-7 ID:SGTC_2401|Compound:5128683|FD-Score:7.59|P-value:9.11E-6 ID:SGTC_2436|Compound:5633522|FD-Score:7.72|P-value:6.57E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:22.00|P-value:1.01E-35 ID:SGTC_2507|Compound:purpurin|FD-Score:8.60|P-value:6.03E-7 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:16.20|P-value:3.44E-20 ID:SGTC_2515|Compound:chrysin|FD-Score:7.14|P-value:2.77E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:10.70|P-value:7.48E-10 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.85|P-value:5.50E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:12.80|P-value:2.24E-13 ID:SGTC_2619|Compound:obliquin|FD-Score:34.60|P-value:3.41E-85 ID:SGTC_2651|Compound:1327-0036|FD-Score:-7.77|P-value:5.84E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:9.46|P-value:4.71E-8 ID:SGTC_2743|Compound:auranofin|FD-Score:6.54|P-value:1.11E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.86|P-value:4.66E-4 ID:SGTC_2791|Compound:5663188|FD-Score:7.35|P-value:1.68E-5 ID:SGTC_2800|Compound:7887935|FD-Score:6.18|P-value:2.44E-4 ID:SGTC_2810|Compound:7959871|FD-Score:6.13|P-value:2.68E-4 ID:SGTC_2954|Compound:9074818|FD-Score:7.13|P-value:2.85E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-8.68|P-value:4.80E-7 ID:SGTC_2970|Compound:9090938|FD-Score:5.70|P-value:6.44E-4 ID:SGTC_2991|Compound:9074669|FD-Score:5.87|P-value:4.62E-4 ID:SGTC_3004|Compound:9076122|FD-Score:6.71|P-value:7.65E-5 ID:SGTC_3020|Compound:9089140|FD-Score:5.65|P-value:7.09E-4 ID:SGTC_3039|Compound:9090270|FD-Score:6.71|P-value:7.68E-5 ID:SGTC_3098|Compound:9119039|FD-Score:6.22|P-value:2.25E-4 ID:SGTC_3182|Compound:9108849|FD-Score:5.48|P-value:9.92E-4 ID:SGTC_3219|Compound:9131112|FD-Score:8.37|P-value:1.16E-6 ID:SGTC_3225|Compound:9130819|FD-Score:6.20|P-value:2.31E-4 ID:SGTC_3232|Compound:9132874|FD-Score:11.20|P-value:1.53E-10 ID:SGTC_3270|Compound:9137563|FD-Score:6.08|P-value:2.98E-4 ID:SGTC_3350|Compound:9150499|FD-Score:6.93|P-value:4.56E-5 ID:SGTC_3351|Compound:9150312|FD-Score:9.82|P-value:1.52E-8

Top fitness defect scores for YER133W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2619 obliquin 34.60 87.9 µM 3.41E-85 cell wall 1 1.44E-262 13.10
2 SGTC_241 5hr heat shock (37°C) + cantharidin 32.30 155.4 µM 1.88E-74 cell wall signaling 1 6.68E-229 20.50
3 SGTC_227 fluconazole 30.20 33.5 µM 3.11E-65 azole & statin 3 5.06E-200 10.50
4 SGTC_2021 4019055 23.80 173.0 µM 2.06E-41 endomembrane recycling 1 1.93E-125 8.93
5 SGTC_2489 cantharidin 22.00 73.4 µM 1.01E-35 cell wall signaling 1 1.19E-107 12.70
6 SGTC_39 0986-0283 20.70 58.4 µM 1.08E-31 calcium & mitochondrial duress 1 4.71E-95 6.38
7 SGTC_467 ro 31-8220 19.60 72.8 µM 8.53E-29 calcium & mitochondrial duress 1 5.25E-86 6.09
8 SGTC_863 0466-0191 18.80 129.0 µM 1.43E-26 cell wall 2 4.62E-79 8.70
9 SGTC_1627 st003713 18.10 25.6 µM 7.59E-25 calcium & mitochondrial duress 1 1.12E-73 12.70
10 SGTC_2057 5236571 16.40 38.3 µM 9.18E-21 RPP1 & pyrimidine depletion 2 6.01E-61 4.13
11 SGTC_1625 st003711 16.30 30.1 µM 1.92E-20 calcium & mitochondrial duress 1 5.97E-60 12.70
12 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 16.20 54.6 µM 3.44E-20 RPP1 & pyrimidine depletion 1 3.68E-59 6.41
13 SGTC_408 cantharidin 15.70 100.0 µM 3.78E-19 cell wall signaling 1 6.46E-56 8.73
14 SGTC_422 cantharidin 15.60 155.0 µM 7.60E-19 cell wall signaling 1 5.66E-55 10.60
15 SGTC_1597 7-benzyloxygramine 15.10 47.5 µM 9.84E-18 calcium & mitochondrial duress 8 1.64E-51 0.59
16 SGTC_1057 3448-5381 13.80 134.0 µM 2.73E-15 calcium & mitochondrial duress 2 6.48E-44 5.48
17 SGTC_351 caspofungin 13.00 25.0 nM 9.18E-14 cell wall 2 3.55E-39 3.52
18 SGTC_2342 7990637 12.90 118.9 µM 1.64E-13 RNA processing & uracil transport 1 2.13E-38 5.96
19 SGTC_2566 crystal violet carbinol 12.80 226.0 nM 2.24E-13 1 5.62E-38 3.47
20 SGTC_1959 st077091 11.90 55.8 µM 8.84E-12 RPP1 & pyrimidine depletion 3 4.99E-33 3.22

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.284 1.85E-63 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.264 1.70E-54 YJL129C TRK1 hom Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication
0.234 4.20E-43 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.220 7.62E-38 YDR293C SSD1 hom Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
0.218 2.22E-37 YKL037W AIM26 hom Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT
0.215 3.24E-36 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.213 1.25E-35 YCR093W CDC39 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.210 1.21E-34 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication
0.200 1.93E-31 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
0.197 9.94E-31 YGR285C ZUO1 hom Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
0.197 1.42E-30 YIL154C IMP2' hom Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
0.195 3.66E-30 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W
0.190 1.70E-28 YKL058W TOA2 het TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.182 2.09E-26 YFL025C BST1 hom GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
0.182 1.92E-26 YBR109C CMD1 het Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin