HIPHOP chemogenomics database
YER134C 
Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER134C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.124 | 5.72E-13 | YKL157W | APE2 | hom | Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication |
| 0.116 | 1.97E-11 | YDR032C | PST2 | hom | Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication |
| 0.111 | 1.09E-10 | YDR371W_p | CTS2_p | hom | Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect |
| 0.088 | 3.35E-7 | YPL035C_d | YPL035C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene |
| 0.077 | 7.64E-6 | YKL107W_p | YKL107W_p | hom | Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein |
| 0.075 | 1.25E-5 | YPL262W | FUM1 | hom | Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria |
| 0.075 | 1.25E-5 | YHR195W | NVJ1 | hom | Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) |
| 0.075 | 1.31E-5 | YMR167W | MLH1 | hom | Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer |
| 0.073 | 2.34E-5 | YHR149C | SKG6 | hom | Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p |
| 0.071 | 3.59E-5 | YCL036W | GFD2 | hom | Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication |
| 0.071 | 3.80E-5 | YJR131W | MNS1 | hom | Alpha-1,2-mannosidase involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation |
| 0.071 | 4.28E-5 | YOR266W | PNT1 | hom | Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine |
| 0.069 | 6.81E-5 | YPL039W_p | YPL039W_p | hom | Putative protein of unknown function; YPL039W is not an essential gene |
| 0.069 | 7.07E-5 | YLR124W_d | YLR124W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| 0.068 | 7.19E-5 | YBR018C | GAL7 | hom | Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism |