YER139C / RTR1

CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YER139C / RTR1

Click on Significant Values for Screen Details ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.36|P-value:4.18E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.57|P-value:2.97E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.23|P-value:6.49E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.06|P-value:2.87E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.47|P-value:4.78E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.39|P-value:3.69E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.28|P-value:5.58E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.17|P-value:1.57E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:5.03|P-value:3.17E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.71|P-value:1.56E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.14|P-value:8.89E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.17|P-value:7.90E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.21|P-value:7.10E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.36|P-value:4.23E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.26|P-value:5.90E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.02|P-value:3.37E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.43|P-value:5.75E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.46|P-value:5.07E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.44|P-value:3.79E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.29|P-value:7.66E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.30|P-value:5.09E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.42|P-value:4.97E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.84|P-value:8.52E-7 ID:SGTC_1616|Compound:st002734|FD-Score:4.57|P-value:3.04E-6 ID:SGTC_1619|Compound:st003326|FD-Score:-3.69|P-value:1.87E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.43|P-value:4.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.26|P-value:5.89E-4 ID:SGTC_1784|Compound:st039334|FD-Score:10.10|P-value:9.55E-24 ID:SGTC_1920|Compound:st075728|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.38|P-value:3.89E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.43|P-value:3.26E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.21|P-value:7.09E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.25|P-value:6.09E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.26|P-value:1.21E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.35|P-value:4.39E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.95|P-value:2.06E-9 ID:SGTC_2936|Compound:9038235|FD-Score:4.21|P-value:1.52E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.94|P-value:4.55E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.80|P-value:7.99E-5 ID:SGTC_3162|Compound:9099653|FD-Score:3.18|P-value:7.82E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.06|P-value:2.86E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.24|P-value:2.09E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:3.36|P-value:4.18E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:4.57|P-value:2.97E-6 ID:SGTC_375|Compound:3970-0961|FD-Score:3.23|P-value:6.49E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.06|P-value:2.87E-5 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.62|P-value:1.64E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:4.47|P-value:4.78E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.80|P-value:8.00E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.39|P-value:3.69E-4 ID:SGTC_1023|Compound:4482-3888|FD-Score:3.28|P-value:5.58E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:5.17|P-value:1.57E-7 ID:SGTC_1136|Compound:pergolide|FD-Score:5.03|P-value:3.17E-7 ID:SGTC_1145|Compound:3546-0597|FD-Score:4.71|P-value:1.56E-6 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.14|P-value:8.89E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.17|P-value:7.90E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.21|P-value:7.10E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.36|P-value:4.23E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.26|P-value:5.90E-4 ID:SGTC_1361|Compound:1608-0041|FD-Score:4.02|P-value:3.37E-5 ID:SGTC_1424|Compound:4048-1941|FD-Score:4.43|P-value:5.75E-6 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.18|P-value:1.74E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:4.46|P-value:5.07E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:5.44|P-value:3.79E-8 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.29|P-value:7.66E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.30|P-value:5.09E-4 ID:SGTC_1608|Compound:st001473|FD-Score:-3.42|P-value:4.97E-4 ID:SGTC_1610|Compound:st001799|FD-Score:4.84|P-value:8.52E-7 ID:SGTC_1616|Compound:st002734|FD-Score:4.57|P-value:3.04E-6 ID:SGTC_1619|Compound:st003326|FD-Score:-3.69|P-value:1.87E-4 ID:SGTC_1628|Compound:st004252|FD-Score:-3.43|P-value:4.72E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.12|P-value:9.43E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.26|P-value:5.89E-4 ID:SGTC_1784|Compound:st039334|FD-Score:10.10|P-value:9.55E-24 ID:SGTC_1920|Compound:st075728|FD-Score:3.74|P-value:1.04E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.38|P-value:3.89E-4 ID:SGTC_2004|Compound:4023728|FD-Score:3.43|P-value:3.26E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.21|P-value:7.09E-4 ID:SGTC_2173|Compound:5763948|FD-Score:3.25|P-value:6.09E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.56|P-value:2.03E-4 ID:SGTC_2225|Compound:6654152|FD-Score:4.26|P-value:1.21E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.35|P-value:4.39E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.95|P-value:2.06E-9 ID:SGTC_2936|Compound:9038235|FD-Score:4.21|P-value:1.52E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.94|P-value:4.55E-5 ID:SGTC_3058|Compound:9093861|FD-Score:3.80|P-value:7.99E-5 ID:SGTC_3162|Compound:9099653|FD-Score:3.18|P-value:7.82E-4 ID:SGTC_3336|Compound:9143619|FD-Score:4.06|P-value:2.86E-5 ID:SGTC_3353|Compound:9151644|FD-Score:-4.24|P-value:2.09E-5

Top fitness defect scores for YER139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1784 st039334 10.10 36.3 µM 9.55E-24 1 1.81E-24
2 SGTC_2817 7995342 5.95 71.4 µM 2.06E-9 3 1.31E-9
3 SGTC_1514 1189-1591 5.44 158.0 µM 3.79E-8 15 2.67E-8
4 SGTC_1119 parthenolide 5.17 318.5 nM 1.57E-7 TSC3-RPN4 18 1.16E-7
5 SGTC_1136 pergolide 5.03 1.1 µM 3.17E-7 13 2.39E-7
6 SGTC_1610 st001799 4.84 48.1 µM 8.52E-7 5 6.63E-7
7 SGTC_1145 3546-0597 4.71 10.2 µM 1.56E-6 mitochondrial processes 10 1.24E-6
8 SGTC_270 tamoxifen 4.57 5.5 µM 2.97E-6 NEO1 16 2.40E-6
9 SGTC_1616 st002734 4.57 56.1 µM 3.04E-6 15 2.46E-6
10 SGTC_729 4092-0585 4.47 94.1 µM 4.78E-6 18 3.92E-6
11 SGTC_1510 1123-0200 4.46 71.5 µM 5.07E-6 31 4.18E-6
12 SGTC_1424 4048-1941 4.43 275.0 µM 5.75E-6 15 4.76E-6
13 SGTC_2225 6654152 4.26 15.4 µM 1.21E-5 10 1.02E-5
14 SGTC_2936 9038235 4.21 15.6 µM 1.52E-5 13 1.29E-5
15 SGTC_1428 4049-0204 4.18 61.7 µM 1.74E-5 8 1.49E-5
16 SGTC_3336 9143619 4.06 71.4 µM 2.86E-5 19 2.48E-5
17 SGTC_440 fluspirilene 4.06 35.1 µM 2.87E-5 11 2.49E-5
18 SGTC_1361 1608-0041 4.02 5.6 µM 3.37E-5 RPP1 & pyrimidine depletion 17 2.94E-5
19 SGTC_2958 9077254 3.94 16.7 µM 4.55E-5 31 4.00E-5
20 SGTC_3058 9093861 3.80 49.5 µM 7.99E-5 22 7.14E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.141 1.95E-16 YDL134C PPH21 hom Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
0.103 2.21E-9 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.096 2.85E-8 YNL150W_d YNL150W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking
0.093 7.06E-8 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.089 2.62E-7 YNL196C_p SLZ1_p hom Sporulation-specific protein with a leucine zipper motif
0.087 4.48E-7 YGR266W YGR266W hom Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress
0.085 7.83E-7 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.082 1.73E-6 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.082 2.25E-6 YBR146W MRPS9 hom Mitochondrial ribosomal protein of the small subunit
0.081 2.33E-6 YEL020C_p YEL020C_p hom Protein of unknown function with low sequence identity to Pdc1p; mRNA identified as translated by ribosome profiling data
0.081 2.34E-6 YBR254C TRS20 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
0.081 2.91E-6 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.079 4.35E-6 YJL203W PRP21 het Subunit of the SF3a splicing factor complex, required for spliceosome assembly
0.079 4.49E-6 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.079 4.67E-6 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication