HIPHOP chemogenomics database

YER141W / COX15

Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase

Zygosity: Homozygous strain

fixedexpanded
Profile for YER141W / COX15

Click on Significant Values for Screen Details

Top fitness defect scores for YER141W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	27.20	5.3 µM	5.46E-184		24	1.62E-163
2	SGTC_386	1509-0011	14.50	3.1 µM	4.12E-54		23	3.40E-48
3	SGTC_1635	st007035	9.84	42.4 µM	6.41E-26		76	3.64E-23
4	SGTC_70	0141-0289	9.00	43.3 µM	5.27E-22	mitochondrial stress	26	1.09E-19
5	SGTC_134	0269-0018	8.57	6.9 µM	4.28E-20		55	5.40E-18
6	SGTC_1746	st038117	7.23	42.0 µM	7.36E-15		2	2.41E-13
7	SGTC_275	trichlorophene	5.81	5.7 µM	3.14E-10	mitochondrial stress	125	3.12E-9
8	SGTC_214	4373-3496	5.67	70.0 µM	8.07E-10		16	7.21E-9
9	SGTC_2402	5553605	5.48	200.0 µM	2.65E-9		7	2.08E-8
10	SGTC_2125	5246583	5.17	200.0 µM	1.85E-8	tubulin folding & SWR complex	22	1.17E-7
11	SGTC_149	3970-0822	4.96	46.1 µM	6.45E-8	tubulin folding & SWR complex	51	3.54E-7
12	SGTC_168	3970-0862	4.43	530.5 µM	1.17E-6		92	4.67E-6
13	SGTC_59	0330-0160	4.34	1.3 µM	1.91E-6		92	7.18E-6
14	SGTC_1506	4226-2149	4.23	212.0 µM	3.26E-6		23	1.16E-5
15	SGTC_2692	st077426	4.13	47.7 µM	5.35E-6		21	1.80E-5
16	SGTC_3310	9130229	4.10	44.1 µM	6.16E-6	Golgi	23	2.04E-5
17	SGTC_3080	9117754	3.99	49.5 µM	1.05E-5		17	3.28E-5
18	SGTC_2503	beta-caryophyllene alcohol	3.97	24.7 µM	1.18E-5		10	3.64E-5
19	SGTC_68	0986-0284	3.90	82.8 µM	1.61E-5		73	4.79E-5
20	SGTC_1069	diphenylcyclopropenone	3.89	8.5 µM	1.68E-5		34	4.98E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	ORF	Gene	Zygosity	Description
0.704	YJL166W	QCR8	hom	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.702	YOR330C	MIP1	hom	Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.698	YDR230W_d	YDR230W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.697	YPL215W	CBP3	hom	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.684	YJL022W_d	YJL022W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.670	YPL013C	MRPS16	hom	Mitochondrial ribosomal protein of the small subunit
0.669	YPL132W	COX11	hom	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.665	YMR035W	IMP2	hom	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.651	YNR045W	PET494	hom	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.651	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.648	YDR518W	EUG1	hom	Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.646	YHR116W	COX23	hom	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.642	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.640	YOR065W	CYT1	hom	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.631	YER058W	PET117	hom	Protein required for assembly of cytochrome c oxidase