YER141W / COX15

Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase

Zygosity: Homozygous strain
fixedexpanded
Profile for YER141W / COX15

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.35|P-value:1.73E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.34|P-value:1.91E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.90|P-value:1.61E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:9.00|P-value:5.27E-22 ID:SGTC_71|Compound:0417-1750|FD-Score:2.99|P-value:7.07E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.98|P-value:7.37E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.95|P-value:8.14E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.57|P-value:4.28E-20 ID:SGTC_149|Compound:3970-0822|FD-Score:4.96|P-value:6.45E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:3.97E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.43|P-value:1.17E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:5.67|P-value:8.07E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:27.20|P-value:5.46E-184 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.81|P-value:3.14E-10 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.23|P-value:3.28E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:14.50|P-value:4.12E-54 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.03|P-value:7.01E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.02|P-value:7.14E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.30|P-value:2.20E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.89|P-value:1.68E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-2.96|P-value:8.94E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:3.07E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.01|P-value:6.65E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.87|P-value:2.18E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:2.94|P-value:8.59E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.23|P-value:3.26E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.48|P-value:1.21E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.10|P-value:4.64E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.03|P-value:6.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.84|P-value:6.41E-26 ID:SGTC_1683|Compound:st010134|FD-Score:-3.16|P-value:4.22E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.06|P-value:9.18E-6 ID:SGTC_1746|Compound:st038117|FD-Score:7.23|P-value:7.36E-15 ID:SGTC_1749|Compound:st037932|FD-Score:-4.57|P-value:6.71E-7 ID:SGTC_1889|Compound:st059080|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.11|P-value:4.45E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.17|P-value:3.59E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.17|P-value:1.85E-8 ID:SGTC_2393|Compound:9031399|FD-Score:-3.35|P-value:2.00E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-2.94|P-value:9.78E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.48|P-value:2.65E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.22|P-value:3.42E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.11|P-value:4.52E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.13|P-value:2.90E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.30|P-value:2.46E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.13|P-value:5.35E-6 ID:SGTC_2798|Compound:7813637|FD-Score:2.95|P-value:8.10E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.19|P-value:3.30E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.36|P-value:1.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.07|P-value:6.09E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.99|P-value:1.05E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.10|P-value:6.16E-6 ID:SGTC_38|Compound:0929-0051|FD-Score:3.35|P-value:1.73E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:4.34|P-value:1.91E-6 ID:SGTC_68|Compound:0986-0284|FD-Score:3.90|P-value:1.61E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:9.00|P-value:5.27E-22 ID:SGTC_71|Compound:0417-1750|FD-Score:2.99|P-value:7.07E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:2.91|P-value:9.64E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:2.98|P-value:7.37E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:2.95|P-value:8.14E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:8.57|P-value:4.28E-20 ID:SGTC_149|Compound:3970-0822|FD-Score:4.96|P-value:6.45E-8 ID:SGTC_150|Compound:3970-0969|FD-Score:2.98|P-value:7.44E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.74|P-value:3.97E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:4.43|P-value:1.17E-6 ID:SGTC_214|Compound:4373-3496|FD-Score:5.67|P-value:8.07E-10 ID:SGTC_236|Compound:1509-0011|FD-Score:27.20|P-value:5.46E-184 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.81|P-value:3.14E-10 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.23|P-value:3.28E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:14.50|P-value:4.12E-54 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.03|P-value:7.01E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.02|P-value:7.14E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.22|P-value:2.98E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.30|P-value:2.20E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.89|P-value:1.68E-5 ID:SGTC_1139|Compound:k015-0024|FD-Score:-2.96|P-value:8.94E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.79|P-value:3.07E-5 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.01|P-value:6.65E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.87|P-value:2.18E-5 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:2.94|P-value:8.59E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.23|P-value:3.26E-6 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.48|P-value:1.21E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.10|P-value:4.64E-4 ID:SGTC_1626|Compound:st003712|FD-Score:3.03|P-value:6.02E-4 ID:SGTC_1635|Compound:st007035|FD-Score:9.84|P-value:6.41E-26 ID:SGTC_1683|Compound:st010134|FD-Score:-3.16|P-value:4.22E-4 ID:SGTC_1742|Compound:st038235|FD-Score:-4.06|P-value:9.18E-6 ID:SGTC_1746|Compound:st038117|FD-Score:7.23|P-value:7.36E-15 ID:SGTC_1749|Compound:st037932|FD-Score:-4.57|P-value:6.71E-7 ID:SGTC_1889|Compound:st059080|FD-Score:3.33|P-value:1.89E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.11|P-value:4.45E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.17|P-value:3.59E-4 ID:SGTC_2125|Compound:5246583|FD-Score:5.17|P-value:1.85E-8 ID:SGTC_2393|Compound:9031399|FD-Score:-3.35|P-value:2.00E-4 ID:SGTC_2401|Compound:5128683|FD-Score:-2.94|P-value:9.78E-4 ID:SGTC_2402|Compound:5553605|FD-Score:5.48|P-value:2.65E-9 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.22|P-value:3.42E-4 ID:SGTC_2589|Compound:lobaric acid|FD-Score:3.11|P-value:4.52E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-5.13|P-value:2.90E-8 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.30|P-value:2.46E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.13|P-value:5.35E-6 ID:SGTC_2798|Compound:7813637|FD-Score:2.95|P-value:8.10E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.19|P-value:3.30E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.36|P-value:1.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.07|P-value:6.09E-4 ID:SGTC_3080|Compound:9117754|FD-Score:3.99|P-value:1.05E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.10|P-value:6.16E-6

Top fitness defect scores for YER141W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 27.20 5.3 µM 5.46E-184 24 1.62E-163
2 SGTC_386 1509-0011 14.50 3.1 µM 4.12E-54 23 3.40E-48
3 SGTC_1635 st007035 9.84 42.4 µM 6.41E-26 76 3.64E-23
4 SGTC_70 0141-0289 9.00 43.3 µM 5.27E-22 mitochondrial stress 26 1.09E-19
5 SGTC_134 0269-0018 8.57 6.9 µM 4.28E-20 55 5.40E-18
6 SGTC_1746 st038117 7.23 42.0 µM 7.36E-15 2 2.41E-13
7 SGTC_275 trichlorophene 5.81 5.7 µM 3.14E-10 mitochondrial stress 125 3.12E-9
8 SGTC_214 4373-3496 5.67 70.0 µM 8.07E-10 16 7.21E-9
9 SGTC_2402 5553605 5.48 200.0 µM 2.65E-9 7 2.08E-8
10 SGTC_2125 5246583 5.17 200.0 µM 1.85E-8 tubulin folding & SWR complex 22 1.17E-7
11 SGTC_149 3970-0822 4.96 46.1 µM 6.45E-8 tubulin folding & SWR complex 51 3.54E-7
12 SGTC_168 3970-0862 4.43 530.5 µM 1.17E-6 92 4.67E-6
13 SGTC_59 0330-0160 4.34 1.3 µM 1.91E-6 92 7.18E-6
14 SGTC_1506 4226-2149 4.23 212.0 µM 3.26E-6 23 1.16E-5
15 SGTC_2692 st077426 4.13 47.7 µM 5.35E-6 21 1.80E-5
16 SGTC_3310 9130229 4.10 44.1 µM 6.16E-6 Golgi 23 2.04E-5
17 SGTC_3080 9117754 3.99 49.5 µM 1.05E-5 17 3.28E-5
18 SGTC_2503 beta-caryophyllene alcohol 3.97 24.7 µM 1.18E-5 10 3.64E-5
19 SGTC_68 0986-0284 3.90 82.8 µM 1.61E-5 73 4.79E-5
20 SGTC_1069 diphenylcyclopropenone 3.89 8.5 µM 1.68E-5 34 4.98E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.704 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.702 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.698 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.697 0 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.684 0 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.670 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.669 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.665 0 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.651 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.651 0 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.648 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.646 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.642 0 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.640 0 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.631 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase