HIPHOP chemogenomics database

YER143W / DDI1

DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains

Zygosity: Homozygous strain

fixedexpanded
Profile for YER143W / DDI1

Click on Significant Values for Screen Details

Top fitness defect scores for YER143W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1897	st060201	5.15	15.0 µM	1.46E-8	mitochondrial processes	10	1.32E-7
2	SGTC_919	tnp00227	4.90	403.6 nM	6.21E-8	RNA pol III & RNase P/MRP	13	4.69E-7
3	SGTC_2952	9073731	4.39	13.8 µM	1.05E-6	tubulin folding & SWR complex	25	5.54E-6
4	SGTC_969	1313-0238	4.23	134.0 µM	2.41E-6	mitochondrial processes	18	1.15E-5
5	SGTC_2520	obtusaquinone	4.01	4.7 µM	7.33E-6		18	3.04E-5
6	SGTC_2702	st077768	4.00	96.8 µM	7.72E-6		15	3.17E-5
7	SGTC_1460	k062-0059	3.81	9.2 µM	1.88E-5	Golgi	18	6.90E-5
8	SGTC_3303	9125618	3.79	40.6 µM	2.07E-5		52	7.51E-5
9	SGTC_1349	flufenamic acid	3.62	69.0 µM	4.55E-5		22	1.50E-4
10	SGTC_263	alizarin	3.59	107.9 µM	5.04E-5	iron homeostasis	76	1.63E-4
11	SGTC_2754	granisetron	3.53	64.0 µM	6.55E-5		45	2.05E-4
12	SGTC_1288	0973-0013	3.41	65.5 µM	1.09E-4		32	3.21E-4
13	SGTC_2526	patulin	3.41	37.6 µM	1.12E-4		131	3.28E-4
14	SGTC_3083	9117465	3.40	49.5 µM	1.14E-4		39	3.35E-4
15	SGTC_1285	0929-0069	3.30	65.5 µM	1.76E-4		43	4.88E-4
16	SGTC_2727	riluzole	3.26	51.8 µM	2.05E-4	mitochondrial processes	27	5.57E-4
17	SGTC_3349	9149703	3.25	23.0 µM	2.14E-4		34	5.78E-4
18	SGTC_995	3931-2021	3.25	34.6 µM	2.16E-4	RPP1 & pyrimidine depletion	43	5.83E-4
19	SGTC_754	3474-0146	3.24	171.0 µM	2.25E-4	copper-dependent oxidative stress	52	6.05E-4
20	SGTC_2191	5911152	3.22	200.0 µM	2.40E-4		37	6.38E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.22E-13	YER037W	PHM8	hom	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p
0.102	3.81E-9	YJR052W	RAD7	hom	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
0.097	1.99E-8	YOL028C	YAP7	hom	Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication
0.091	1.19E-7	YLR262C-A	TMA7	hom	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress
0.091	1.32E-7	YLR018C	POM34	hom	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.089	2.23E-7	YJL146W	IDS2	hom	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
0.088	3.15E-7	YHR134W	WSS1	hom	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response
0.088	3.30E-7	YER013W	PRP22	het	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.086	7.00E-7	YNL031C	HHT2	hom	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation
0.085	7.72E-7	YNL237W	YTP1	hom	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
0.084	9.50E-7	YGR036C	CAX4	hom	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
0.082	1.77E-6	YNL095C_p	YNL095C_p	hom	Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication
0.078	5.44E-6	YOR272W	YTM1	het	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
0.072	3.03E-5	YHR093W_d	AHT1_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
0.071	4.08E-5	YKL017C	HCS1	hom	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities