YER146W / LSM5

Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER146W / LSM5

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-4.07|P-value:1.82E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.33|P-value:5.39E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.14|P-value:8.71E-8 ID:SGTC_192|Compound:3455-0609|FD-Score:3.14|P-value:6.97E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.37|P-value:3.15E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.12|P-value:9.51E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:4.38|P-value:4.28E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.19|P-value:5.88E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.51|P-value:2.24E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.84|P-value:4.77E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.06|P-value:1.82E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.86|P-value:4.35E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.30|P-value:6.21E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.70|P-value:8.48E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:7.51E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.32E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.67|P-value:9.39E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.25|P-value:7.91E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.25|P-value:4.81E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.72|P-value:8.06E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.89|P-value:3.87E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.81|P-value:5.34E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.57|P-value:1.72E-6 ID:SGTC_1663|Compound:st014140|FD-Score:4.12|P-value:1.42E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.06|P-value:9.33E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.52|P-value:1.74E-4 ID:SGTC_1735|Compound:st034310|FD-Score:5.81|P-value:1.70E-9 ID:SGTC_1738|Compound:st035555|FD-Score:4.47|P-value:2.69E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-3.64|P-value:1.10E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.90|P-value:3.60E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.66|P-value:9.87E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.89|P-value:3.83E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.16|P-value:1.16E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.72|P-value:7.78E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.30|P-value:6.24E-6 ID:SGTC_2241|Compound:6772625|FD-Score:3.21|P-value:5.50E-4 ID:SGTC_2297|Compound:7971671|FD-Score:7.95|P-value:3.30E-16 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.70|P-value:8.55E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.05|P-value:9.69E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.06|P-value:9.23E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.13|P-value:7.32E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.13|P-value:7.28E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.59|P-value:1.50E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.92|P-value:3.37E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.54|P-value:1.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.65|P-value:1.04E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.62|P-value:1.33E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.70|P-value:8.44E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.83|P-value:1.59E-9 ID:SGTC_3313|Compound:9133968|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.62|P-value:5.59E-9 ID:SGTC_3320|Compound:9137005|FD-Score:4.43|P-value:3.27E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.07|P-value:1.82E-5 ID:SGTC_152|Compound:4469-0003|FD-Score:4.33|P-value:5.39E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:5.14|P-value:8.71E-8 ID:SGTC_192|Compound:3455-0609|FD-Score:3.14|P-value:6.97E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.51|P-value:1.83E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_405|Compound:ebelactone b|FD-Score:3.53|P-value:1.67E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.37|P-value:3.15E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:5.12|P-value:9.51E-8 ID:SGTC_520|Compound:3584-0023|FD-Score:4.38|P-value:4.28E-6 ID:SGTC_526|Compound:4469-0568|FD-Score:3.23|P-value:5.12E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:3.19|P-value:5.88E-4 ID:SGTC_561|Compound:1550-0330|FD-Score:4.51|P-value:2.24E-6 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.84|P-value:4.77E-5 ID:SGTC_628|Compound:1636-0253|FD-Score:4.06|P-value:1.82E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.86|P-value:4.35E-5 ID:SGTC_641|Compound:4092-0595|FD-Score:3.07|P-value:8.83E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.30|P-value:6.21E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.19|P-value:5.84E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.70|P-value:8.48E-5 ID:SGTC_740|Compound:k014-0057|FD-Score:3.12|P-value:7.51E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.44|P-value:3.32E-6 ID:SGTC_797|Compound:k781-0471|FD-Score:3.67|P-value:9.39E-5 ID:SGTC_806|Compound:3966-4455|FD-Score:3.62|P-value:1.14E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:-4.25|P-value:7.91E-6 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.25|P-value:4.81E-4 ID:SGTC_1011|Compound:4112-3381|FD-Score:-3.72|P-value:8.06E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.89|P-value:3.87E-5 ID:SGTC_1104|Compound:tacrolimus|FD-Score:3.12|P-value:7.66E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.45|P-value:2.27E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.81|P-value:5.34E-5 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.16|P-value:6.55E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.12|P-value:7.59E-4 ID:SGTC_1588|Compound:farnesol|FD-Score:4.57|P-value:1.72E-6 ID:SGTC_1663|Compound:st014140|FD-Score:4.12|P-value:1.42E-5 ID:SGTC_1664|Compound:st014217|FD-Score:3.64|P-value:1.06E-4 ID:SGTC_1697|Compound:st025554|FD-Score:3.06|P-value:9.33E-4 ID:SGTC_1721|Compound:st082152|FD-Score:3.52|P-value:1.74E-4 ID:SGTC_1735|Compound:st034310|FD-Score:5.81|P-value:1.70E-9 ID:SGTC_1738|Compound:st035555|FD-Score:4.47|P-value:2.69E-6 ID:SGTC_1740|Compound:st038286|FD-Score:-3.64|P-value:1.10E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.90|P-value:3.60E-5 ID:SGTC_1962|Compound:st076595|FD-Score:3.66|P-value:9.87E-5 ID:SGTC_2033|Compound:5192550|FD-Score:3.31|P-value:3.74E-4 ID:SGTC_2057|Compound:5236571|FD-Score:-3.45|P-value:2.28E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.89|P-value:3.83E-5 ID:SGTC_2104|Compound:5389443|FD-Score:3.65|P-value:1.03E-4 ID:SGTC_2116|Compound:5511452|FD-Score:4.16|P-value:1.16E-5 ID:SGTC_2126|Compound:5251174|FD-Score:-3.72|P-value:7.78E-5 ID:SGTC_2238|Compound:6671620|FD-Score:4.30|P-value:6.24E-6 ID:SGTC_2241|Compound:6772625|FD-Score:3.21|P-value:5.50E-4 ID:SGTC_2297|Compound:7971671|FD-Score:7.95|P-value:3.30E-16 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.70|P-value:8.55E-5 ID:SGTC_2433|Compound:5607874|FD-Score:3.49|P-value:1.91E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:3.11|P-value:7.95E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:-3.05|P-value:9.69E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.06|P-value:9.23E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:-3.13|P-value:7.32E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:3.13|P-value:7.28E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:4.59|P-value:1.50E-6 ID:SGTC_2789|Compound:5281112|FD-Score:3.92|P-value:3.37E-5 ID:SGTC_2854|Compound:9024559|FD-Score:3.54|P-value:1.60E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.65|P-value:1.04E-4 ID:SGTC_2912|Compound:7964298|FD-Score:-4.62|P-value:1.33E-6 ID:SGTC_2971|Compound:9092186|FD-Score:3.70|P-value:8.44E-5 ID:SGTC_3003|Compound:9075612|FD-Score:3.29|P-value:4.08E-4 ID:SGTC_3101|Compound:9120531|FD-Score:3.41|P-value:2.64E-4 ID:SGTC_3149|Compound:9097855|FD-Score:5.83|P-value:1.59E-9 ID:SGTC_3313|Compound:9133968|FD-Score:3.64|P-value:1.09E-4 ID:SGTC_3317|Compound:9138495|FD-Score:5.62|P-value:5.59E-9 ID:SGTC_3320|Compound:9137005|FD-Score:4.43|P-value:3.27E-6

Top fitness defect scores for YER146W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2297 7971671 7.95 152.3 µM 3.30E-16 RNA processing & uracil transport 1 9.58E-16 1.70
2 SGTC_3149 9097855 5.83 49.5 µM 1.59E-9 Golgi 2 2.84E-9 0.26
3 SGTC_1735 st034310 5.81 56.8 µM 1.70E-9 Golgi 1 3.04E-9 1.06
4 SGTC_3317 9138495 5.62 8.8 µM 5.59E-9 7 9.63E-9 0.44
5 SGTC_184 1494-0393 5.14 24.7 µM 8.71E-8 15 1.38E-7 0.02
6 SGTC_519 k048-0011 5.12 62.8 µM 9.51E-8 4 1.50E-7 0.50
7 SGTC_2759 disulfiram 4.59 3.4 µM 1.50E-6 10 2.18E-6 0.06
8 SGTC_1588 farnesol 4.57 29.9 µM 1.72E-6 4 2.49E-6 0.30
9 SGTC_561 1550-0330 4.51 72.9 µM 2.24E-6 2 3.20E-6 0.54
10 SGTC_1738 st035555 4.47 74.0 µM 2.69E-6 TSC3-RPN4 1 3.83E-6 0.35
11 SGTC_3320 9137005 4.43 35.1 µM 3.27E-6 endomembrane recycling 2 4.62E-6 0.95
12 SGTC_520 3584-0023 4.38 682.0 µM 4.28E-6 9 6.00E-6 0.17
13 SGTC_152 4469-0003 4.33 551.2 µM 5.39E-6 10 7.51E-6 0.20
14 SGTC_691 1548-0686 4.30 185.0 µM 6.21E-6 9 8.61E-6 0.36
15 SGTC_2238 6671620 4.30 73.2 µM 6.24E-6 3 8.65E-6 0.20
16 SGTC_2116 5511452 4.16 16.9 µM 1.16E-5 3 1.57E-5 0.61
17 SGTC_1663 st014140 4.12 55.4 µM 1.42E-5 60S ribosome export 3 1.92E-5 1.03
18 SGTC_628 1636-0253 4.06 16.0 µM 1.82E-5 sphingolipid biosynthesis & PDR1 9 2.44E-5 0.17
19 SGTC_2789 5281112 3.92 71.4 µM 3.37E-5 11 4.44E-5 0.09
20 SGTC_1801 st050089 3.90 28.4 µM 3.60E-5 NEO1-PIK1 11 4.73E-5 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.20E-9 YPL026C SKS1 hom Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
0.103 2.17E-9 YLR305C STT4 het Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
0.092 8.83E-8 YGR090W UTP22 het Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
0.088 3.26E-7 YMR241W YHM2 hom Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome
0.087 3.90E-7 YMR001C-A_p YMR001C-A_p hom Putative protein of unknown function
0.086 6.50E-7 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.083 1.53E-6 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.080 3.71E-6 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.079 4.53E-6 YOR316C COT1 hom Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication
0.078 6.41E-6 YDR370C DXO1 hom Protein with decapping and 5′-3′ exoRNase activity; similar to Rai1p
0.077 8.43E-6 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.076 1.00E-5 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.28E-5 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.075 1.54E-5 YGL081W_p YGL081W_p hom Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.075 1.55E-5 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress