YER157W / COG3

Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER157W / COG3

Click on Significant Values for Screen Details ID:SGTC_18|Compound:0111-0177|FD-Score:3.31|P-value:1.05E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:2.93|P-value:5.12E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.26|P-value:1.11E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.20|P-value:1.40E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-2.99|P-value:3.44E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-2.90|P-value:5.00E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-2.79|P-value:7.81E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.30|P-value:9.16E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:2.85|P-value:7.10E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.08|P-value:2.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.05|P-value:2.74E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-4.71|P-value:4.89E-8 ID:SGTC_333|Compound:3486-0131|FD-Score:3.69|P-value:1.80E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.60|P-value:2.77E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:2.89|P-value:6.01E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-2.82|P-value:6.75E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.46|P-value:4.32E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.80|P-value:2.82E-8 ID:SGTC_900|Compound:1112-0045|FD-Score:2.80|P-value:8.55E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.78|P-value:9.49E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.52|P-value:4.11E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.91|P-value:5.65E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.79|P-value:1.07E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.63|P-value:1.96E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.76|P-value:1.25E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.98|P-value:4.36E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.80|P-value:3.56E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.80|P-value:8.36E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.87|P-value:6.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.93|P-value:1.57E-8 ID:SGTC_1752|Compound:st044819|FD-Score:-3.92|P-value:4.38E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.15|P-value:2.09E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.39|P-value:7.41E-5 ID:SGTC_2164|Compound:5685496|FD-Score:7.30|P-value:1.21E-16 ID:SGTC_2280|Compound:7785178|FD-Score:-2.98|P-value:3.60E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:7.71|P-value:2.27E-18 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.18|P-value:1.10E-6 ID:SGTC_2477|Compound:5967686|FD-Score:2.87|P-value:6.71E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.03|P-value:3.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:4.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.48|P-value:4.89E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.61|P-value:2.65E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.61|P-value:2.68E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.04|P-value:2.81E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.81|P-value:8.38E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.75|P-value:8.95E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.08|P-value:2.42E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.79|P-value:8.97E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.31|P-value:1.05E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.06|P-value:2.55E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-7.46|P-value:1.75E-17 ID:SGTC_18|Compound:0111-0177|FD-Score:3.31|P-value:1.05E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:2.93|P-value:5.12E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.26|P-value:1.11E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:-3.20|P-value:1.40E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-2.99|P-value:3.44E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:2.84|P-value:7.48E-4 ID:SGTC_98|Compound:0074-0023|FD-Score:-2.90|P-value:5.00E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:-2.79|P-value:7.81E-4 ID:SGTC_215|Compound:1287-0124|FD-Score:-3.30|P-value:9.16E-5 ID:SGTC_233|Compound:rapamycin|FD-Score:2.85|P-value:7.10E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.08|P-value:2.78E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:-3.05|P-value:2.74E-4 ID:SGTC_271|Compound:rotenone|FD-Score:-4.71|P-value:4.89E-8 ID:SGTC_333|Compound:3486-0131|FD-Score:3.69|P-value:1.80E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:3.60|P-value:2.77E-5 ID:SGTC_651|Compound:3253-0966|FD-Score:2.89|P-value:6.01E-4 ID:SGTC_856|Compound:0433-0016|FD-Score:-2.82|P-value:6.75E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:-3.46|P-value:4.32E-5 ID:SGTC_896|Compound:0964-0007|FD-Score:-4.80|P-value:2.82E-8 ID:SGTC_900|Compound:1112-0045|FD-Score:2.80|P-value:8.55E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:2.78|P-value:9.49E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.52|P-value:4.11E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:2.91|P-value:5.65E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.79|P-value:1.07E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.63|P-value:1.96E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.76|P-value:1.25E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:2.98|P-value:4.36E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.80|P-value:3.56E-8 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.80|P-value:8.36E-6 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:2.87|P-value:6.62E-4 ID:SGTC_1600|Compound:coumarin 106|FD-Score:4.93|P-value:1.57E-8 ID:SGTC_1752|Compound:st044819|FD-Score:-3.92|P-value:4.38E-6 ID:SGTC_1784|Compound:st039334|FD-Score:3.15|P-value:2.09E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.39|P-value:7.41E-5 ID:SGTC_2164|Compound:5685496|FD-Score:7.30|P-value:1.21E-16 ID:SGTC_2280|Compound:7785178|FD-Score:-2.98|P-value:3.60E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:7.71|P-value:2.27E-18 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-4.18|P-value:1.10E-6 ID:SGTC_2477|Compound:5967686|FD-Score:2.87|P-value:6.71E-4 ID:SGTC_2505|Compound:galangin|FD-Score:3.03|P-value:3.45E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:4.13E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.48|P-value:4.89E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.61|P-value:2.65E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.61|P-value:2.68E-5 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:-3.04|P-value:2.81E-4 ID:SGTC_2608|Compound:thymoquinone|FD-Score:2.81|P-value:8.38E-4 ID:SGTC_2652|Compound:actinonin|FD-Score:-2.75|P-value:8.95E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:-3.08|P-value:2.42E-4 ID:SGTC_2792|Compound:7535235|FD-Score:2.79|P-value:8.97E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.31|P-value:1.05E-4 ID:SGTC_3207|Compound:9114163|FD-Score:-3.06|P-value:2.55E-4 ID:SGTC_3212|Compound:9128307|FD-Score:-7.46|P-value:1.75E-17

Top fitness defect scores for YER157W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2407 paclitaxel 7.71 400.0 µM 2.27E-18 1 6.29E-15 3.10
2 SGTC_2164 5685496 7.30 200.0 µM 1.21E-16 2 1.47E-13 1.39
3 SGTC_1600 coumarin 106 4.93 71.1 µM 1.57E-8 2 4.08E-7 0.18
4 SGTC_1581 himbacine 4.80 57.9 µM 3.56E-8 Golgi 4 7.84E-7 0.60
5 SGTC_1167 k781-0610 3.79 148.0 µM 1.07E-5 RNA processing & uracil transport 7 7.46E-5 0.02
6 SGTC_1468 k284-1086 3.76 134.0 µM 1.25E-5 DNA intercalators 11 8.45E-5 0.15
7 SGTC_333 3486-0131 3.69 40.1 µM 1.80E-5 amide catabolism 5 1.13E-4 0.15
8 SGTC_2595 hexamethylquercetagetin 3.61 100.0 µM 2.65E-5 11 1.54E-4 0.16
9 SGTC_2596 sinensetin 3.61 100.0 µM 2.68E-5 8 1.56E-4 0.03
10 SGTC_425 3825-7017 3.60 13.1 µM 2.77E-5 13 1.60E-4 0.01
11 SGTC_952 1185-0122 3.52 232.0 µM 4.11E-5 8 2.20E-4 0.01
12 SGTC_2543 pimpinellin 3.48 60.7 µM 4.89E-5 Golgi 6 2.52E-4 0.21
13 SGTC_2052 5265182 3.39 7.1 µM 7.41E-5 11 3.52E-4 0.09
14 SGTC_2794 7785382 3.31 27.3 µM 1.05E-4 23 4.65E-4 1.62E-4
15 SGTC_18 0111-0177 3.31 500.0 nM 1.05E-4 7 4.65E-4 0.08
16 SGTC_1784 st039334 3.15 36.3 µM 2.09E-4 18 8.11E-4 0.03
17 SGTC_243 5hr heat shock (37°C) + splitomicin 3.08 1.0 µM 2.78E-4 heat shock/prefoldin 13 0.00102 0.22
18 SGTC_2505 galangin 3.03 7.9 µM 3.45E-4 RPP1 & pyrimidine depletion 14 0.00121 0.06
19 SGTC_2539 epi(13)torulosol 2.99 80.0 µM 4.13E-4 16 0.00140 0.05
20 SGTC_1510 1123-0200 2.98 71.5 µM 4.36E-4 31 0.00146 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.69E-21 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.133 9.96E-15 YOR004W UTP23 het Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
0.125 4.25E-13 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.119 4.62E-12 YER087C-A_d YER087C-A_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase
0.116 1.84E-11 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.108 3.24E-10 YDL053C PBP4 hom Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
0.103 1.94E-9 YLR207W HRD3 hom Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events
0.103 2.27E-9 YOR375C GDH1 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication
0.102 2.84E-9 YNL245C CWC25 het Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p
0.101 3.92E-9 YNL207W RIO2 het Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
0.099 7.87E-9 YOR029W_d YOR029W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 1.72E-8 YBR043C QDR3 hom Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin
0.097 2.01E-8 YER101C AST2 hom Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication
0.096 2.29E-8 YFL021W GAT1 hom Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
0.096 2.43E-8 YAL014C SYN8 hom Endosomal SNARE related to mammalian syntaxin 8