YER165W / PAB1

Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G

Zygosity: Heterozygous strain
fixedexpanded
Profile for YER165W / PAB1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:4.61|P-value:5.06E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.68|P-value:1.07E-13 ID:SGTC_93|Compound:0109-0045|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.78|P-value:1.66E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.31|P-value:8.50E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.42|P-value:1.15E-19 ID:SGTC_192|Compound:3455-0609|FD-Score:3.27|P-value:8.68E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.90|P-value:9.24E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.97|P-value:7.07E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.49|P-value:4.07E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.70|P-value:1.94E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.02|P-value:5.78E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:16.20|P-value:6.07E-54 ID:SGTC_354|Compound:2783-3500|FD-Score:11.20|P-value:3.49E-27 ID:SGTC_356|Compound:1634-0012|FD-Score:4.35|P-value:1.54E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.27|P-value:2.54E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.55|P-value:6.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.41|P-value:1.13E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:3.42|P-value:5.24E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:6.46|P-value:3.26E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:5.68|P-value:2.76E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:4.36|P-value:1.46E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.16|P-value:3.88E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:8.61|P-value:9.87E-17 ID:SGTC_744|Compound:1594-0068|FD-Score:4.19|P-value:3.00E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:4.26|P-value:2.27E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:14.40|P-value:1.45E-43 ID:SGTC_839|Compound:0122-0028|FD-Score:9.62|P-value:1.99E-20 ID:SGTC_854|Compound:0422-0053|FD-Score:3.27|P-value:8.66E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.31|P-value:7.86E-10 ID:SGTC_871|Compound:0574-0004|FD-Score:11.40|P-value:4.34E-28 ID:SGTC_928|Compound:2764-0428|FD-Score:3.38|P-value:5.86E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.58|P-value:2.98E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.19|P-value:2.93E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.39|P-value:1.22E-7 ID:SGTC_1050|Compound:3232-1156|FD-Score:7.72|P-value:8.20E-14 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.55|P-value:5.47E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:6.24|P-value:1.17E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.37|P-value:1.40E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:8.30E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:11.70|P-value:2.68E-29 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.88|P-value:9.38E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.39|P-value:7.87E-13 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.45|P-value:4.78E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.05|P-value:3.60E-9 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.48|P-value:9.05E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.02|P-value:5.98E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:12.00|P-value:9.10E-31 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.97|P-value:7.05E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.42|P-value:5.14E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.13|P-value:4.60E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.65|P-value:2.36E-4 ID:SGTC_1652|Compound:st011932|FD-Score:12.60|P-value:6.85E-34 ID:SGTC_1693|Compound:xanthone|FD-Score:5.14|P-value:4.36E-7 ID:SGTC_1707|Compound:st032323|FD-Score:10.20|P-value:7.08E-23 ID:SGTC_1915|Compound:st067105|FD-Score:8.42|P-value:4.36E-16 ID:SGTC_1930|Compound:st074634|FD-Score:5.55|P-value:5.53E-8 ID:SGTC_2004|Compound:4023728|FD-Score:10.50|P-value:6.38E-24 ID:SGTC_2025|Compound:5147754|FD-Score:6.39|P-value:5.01E-10 ID:SGTC_2027|Compound:5150920|FD-Score:3.33|P-value:7.12E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.09|P-value:4.46E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-4.05|P-value:6.08E-5 ID:SGTC_2041|Compound:5107442|FD-Score:16.90|P-value:9.34E-59 ID:SGTC_2084|Compound:5306078|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_2109|Compound:5483026|FD-Score:7.37|P-value:9.38E-13 ID:SGTC_2111|Compound:5486399|FD-Score:10.30|P-value:5.87E-23 ID:SGTC_2140|Compound:5586273|FD-Score:3.88|P-value:1.00E-4 ID:SGTC_2163|Compound:5671233|FD-Score:8.94|P-value:6.32E-18 ID:SGTC_2186|Compound:6124449|FD-Score:6.42|P-value:4.23E-10 ID:SGTC_2187|Compound:6125751|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.27|P-value:8.62E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.46|P-value:9.57E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.23|P-value:9.71E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.69|P-value:2.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.31|P-value:7.83E-10 ID:SGTC_2361|Compound:9034121|FD-Score:10.80|P-value:4.12E-25 ID:SGTC_2378|Compound:9074213|FD-Score:5.03|P-value:7.41E-7 ID:SGTC_2396|Compound:5342950|FD-Score:4.79|P-value:2.28E-6 ID:SGTC_2400|Compound:5203494|FD-Score:4.26|P-value:2.26E-5 ID:SGTC_2534|Compound:helenine|FD-Score:7.15|P-value:4.05E-12 ID:SGTC_2544|Compound:sphondin|FD-Score:8.18|P-value:2.69E-15 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.33|P-value:1.99E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.52|P-value:4.79E-20 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.30|P-value:7.75E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.68|P-value:1.16E-20 ID:SGTC_3208|Compound:9114115|FD-Score:5.56|P-value:5.16E-8 ID:SGTC_3218|Compound:9131285|FD-Score:3.47|P-value:4.43E-4 ID:SGTC_3247|Compound:9135149|FD-Score:6.00|P-value:4.79E-9 ID:SGTC_3318|Compound:9139014|FD-Score:3.83|P-value:1.19E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.82|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.54|P-value:6.97E-6 ID:SGTC_3331|Compound:9141060|FD-Score:3.39|P-value:5.76E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:4.61|P-value:5.06E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:7.68|P-value:1.07E-13 ID:SGTC_93|Compound:0109-0045|FD-Score:4.26|P-value:2.23E-5 ID:SGTC_100|Compound:0086-0128|FD-Score:-3.78|P-value:1.66E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:-3.31|P-value:8.50E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:9.42|P-value:1.15E-19 ID:SGTC_192|Compound:3455-0609|FD-Score:3.27|P-value:8.68E-4 ID:SGTC_248|Compound:streptozotocin|FD-Score:3.90|P-value:9.24E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.97|P-value:7.07E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:3.49|P-value:4.07E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.70|P-value:1.94E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:4.02|P-value:5.78E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:16.20|P-value:6.07E-54 ID:SGTC_354|Compound:2783-3500|FD-Score:11.20|P-value:3.49E-27 ID:SGTC_356|Compound:1634-0012|FD-Score:4.35|P-value:1.54E-5 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-4.27|P-value:2.54E-5 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:4.55|P-value:6.54E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:5.41|P-value:1.13E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:3.42|P-value:5.24E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:6.46|P-value:3.26E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:5.68|P-value:2.76E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:4.36|P-value:1.46E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:5.16|P-value:3.88E-7 ID:SGTC_673|Compound:1082-0474|FD-Score:8.61|P-value:9.87E-17 ID:SGTC_744|Compound:1594-0068|FD-Score:4.19|P-value:3.00E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:4.26|P-value:2.27E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:14.40|P-value:1.45E-43 ID:SGTC_839|Compound:0122-0028|FD-Score:9.62|P-value:1.99E-20 ID:SGTC_854|Compound:0422-0053|FD-Score:3.27|P-value:8.66E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:6.31|P-value:7.86E-10 ID:SGTC_871|Compound:0574-0004|FD-Score:11.40|P-value:4.34E-28 ID:SGTC_928|Compound:2764-0428|FD-Score:3.38|P-value:5.86E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:3.58|P-value:2.98E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.19|P-value:2.93E-5 ID:SGTC_1028|Compound:k015-0029|FD-Score:5.39|P-value:1.22E-7 ID:SGTC_1050|Compound:3232-1156|FD-Score:7.72|P-value:8.20E-14 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.55|P-value:5.47E-8 ID:SGTC_1085|Compound:doxorubicin|FD-Score:6.24|P-value:1.17E-9 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.37|P-value:1.40E-7 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:8.30E-6 ID:SGTC_1229|Compound:0139-0193|FD-Score:11.70|P-value:2.68E-29 ID:SGTC_1239|Compound:0337-0584|FD-Score:5.88|P-value:9.38E-9 ID:SGTC_1260|Compound:0700-1617|FD-Score:7.39|P-value:7.87E-13 ID:SGTC_1261|Compound:0712-0010|FD-Score:3.45|P-value:4.78E-4 ID:SGTC_1294|Compound:1000-1494|FD-Score:6.05|P-value:3.60E-9 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:4.48|P-value:9.05E-6 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.02|P-value:5.98E-5 ID:SGTC_1346|Compound:1488-2224|FD-Score:3.84|P-value:1.15E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:12.00|P-value:9.10E-31 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.35|P-value:6.61E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.97|P-value:7.05E-5 ID:SGTC_1527|Compound:coumarin|FD-Score:3.42|P-value:5.14E-4 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:5.13|P-value:4.60E-7 ID:SGTC_1547|Compound:harmine|FD-Score:3.65|P-value:2.36E-4 ID:SGTC_1652|Compound:st011932|FD-Score:12.60|P-value:6.85E-34 ID:SGTC_1693|Compound:xanthone|FD-Score:5.14|P-value:4.36E-7 ID:SGTC_1707|Compound:st032323|FD-Score:10.20|P-value:7.08E-23 ID:SGTC_1915|Compound:st067105|FD-Score:8.42|P-value:4.36E-16 ID:SGTC_1930|Compound:st074634|FD-Score:5.55|P-value:5.53E-8 ID:SGTC_2004|Compound:4023728|FD-Score:10.50|P-value:6.38E-24 ID:SGTC_2025|Compound:5147754|FD-Score:6.39|P-value:5.01E-10 ID:SGTC_2027|Compound:5150920|FD-Score:3.33|P-value:7.12E-4 ID:SGTC_2035|Compound:5154463|FD-Score:4.09|P-value:4.46E-5 ID:SGTC_2036|Compound:5160441|FD-Score:-4.05|P-value:6.08E-5 ID:SGTC_2041|Compound:5107442|FD-Score:16.90|P-value:9.34E-59 ID:SGTC_2084|Compound:5306078|FD-Score:3.31|P-value:7.53E-4 ID:SGTC_2109|Compound:5483026|FD-Score:7.37|P-value:9.38E-13 ID:SGTC_2111|Compound:5486399|FD-Score:10.30|P-value:5.87E-23 ID:SGTC_2140|Compound:5586273|FD-Score:3.88|P-value:1.00E-4 ID:SGTC_2163|Compound:5671233|FD-Score:8.94|P-value:6.32E-18 ID:SGTC_2186|Compound:6124449|FD-Score:6.42|P-value:4.23E-10 ID:SGTC_2187|Compound:6125751|FD-Score:3.60|P-value:2.82E-4 ID:SGTC_2229|Compound:7354935|FD-Score:3.27|P-value:8.62E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:3.56|P-value:3.19E-4 ID:SGTC_2277|Compound:7947813|FD-Score:4.46|P-value:9.57E-6 ID:SGTC_2292|Compound:7671323|FD-Score:3.23|P-value:9.71E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.69|P-value:2.00E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.31|P-value:7.83E-10 ID:SGTC_2361|Compound:9034121|FD-Score:10.80|P-value:4.12E-25 ID:SGTC_2378|Compound:9074213|FD-Score:5.03|P-value:7.41E-7 ID:SGTC_2396|Compound:5342950|FD-Score:4.79|P-value:2.28E-6 ID:SGTC_2400|Compound:5203494|FD-Score:4.26|P-value:2.26E-5 ID:SGTC_2534|Compound:helenine|FD-Score:7.15|P-value:4.05E-12 ID:SGTC_2544|Compound:sphondin|FD-Score:8.18|P-value:2.69E-15 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-4.33|P-value:1.99E-5 ID:SGTC_2619|Compound:obliquin|FD-Score:3.33|P-value:7.15E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.52|P-value:4.79E-20 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.30|P-value:7.75E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.80|P-value:1.34E-4 ID:SGTC_2912|Compound:7964298|FD-Score:9.68|P-value:1.16E-20 ID:SGTC_3208|Compound:9114115|FD-Score:5.56|P-value:5.16E-8 ID:SGTC_3218|Compound:9131285|FD-Score:3.47|P-value:4.43E-4 ID:SGTC_3247|Compound:9135149|FD-Score:6.00|P-value:4.79E-9 ID:SGTC_3318|Compound:9139014|FD-Score:3.83|P-value:1.19E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.82|P-value:1.28E-4 ID:SGTC_3322|Compound:9139058|FD-Score:4.54|P-value:6.97E-6 ID:SGTC_3331|Compound:9141060|FD-Score:3.39|P-value:5.76E-4

Top fitness defect scores for YER165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2041 5107442 16.90 45.3 µM 9.34E-59 RSC complex & mRNA processing 1 2.89E-64 2.68
2 SGTC_351 caspofungin 16.20 25.0 nM 6.07E-54 cell wall 1 5.57E-59 3.52
3 SGTC_829 1635-0120 14.40 117.0 µM 1.45E-43 DNA damage response 4 1.39E-47 3.71
4 SGTC_1652 st011932 12.60 78.0 µM 6.85E-34 RSC complex & mRNA processing 8 5.75E-37 0.63
5 SGTC_1374 2889-5571 12.00 141.0 µM 9.10E-31 RSC complex & mRNA processing 10 1.54E-33 0.94
6 SGTC_1229 0139-0193 11.70 12.2 µM 2.68E-29 RSC complex & mRNA processing 1 6.31E-32 2.12
7 SGTC_871 0574-0004 11.40 149.0 µM 4.34E-28 2 1.34E-30 1.07
8 SGTC_354 2783-3500 11.20 4.9 µM 3.49E-27 cell wall 1 1.31E-29 1.33
9 SGTC_2361 9034121 10.80 116.0 µM 4.12E-25 RSC complex & mRNA processing 4 2.47E-27 1.48
10 SGTC_2004 4023728 10.50 41.9 µM 6.38E-24 6 4.98E-26 1.70
11 SGTC_2111 5486399 10.30 200.0 µM 5.87E-23 7 5.69E-25 2.45
12 SGTC_1707 st032323 10.20 6.3 µM 7.08E-23 DNA damage response 8 6.98E-25 1.34
13 SGTC_2912 7964298 9.68 10.9 µM 1.16E-20 cell wall 15 1.88E-22 0.05
14 SGTC_839 0122-0028 9.62 230.0 µM 1.99E-20 RSC complex & mRNA processing 1 3.39E-22 1.82
15 SGTC_2662 daunorubicin 9.52 22.4 µM 4.79E-20 anthracycline transcription coupled DNA repair 4 8.87E-22 2.29
16 SGTC_138 0850-0259 9.42 40.9 µM 1.15E-19 cell wall 12 2.32E-21 0.04
17 SGTC_2163 5671233 8.94 125.0 µM 6.32E-18 1 1.87E-19 2.54
18 SGTC_673 1082-0474 8.61 110.0 µM 9.87E-17 RSC complex & mRNA processing 18 3.81E-18 0.39
19 SGTC_1915 st067105 8.42 30.6 µM 4.36E-16 RNA pol III & RNase P/MRP 9 1.94E-17 0.19
20 SGTC_2544 sphondin 8.18 68.5 µM 2.69E-15 RNA pol III & RNase P/MRP 10 1.42E-16 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.525 1.06E-236 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.495 6.71E-207 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.479 1.93E-192 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.461 2.07E-176 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.458 9.01E-174 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.452 2.42E-168 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.452 3.92E-168 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.451 3.98E-168 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.439 9.20E-158 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.424 1.10E-146 YFR037C RSC8 het Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
0.407 5.79E-134 YBL092W RPL32 het Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog
0.405 3.26E-132 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.404 3.17E-132 YOL005C RPB11 het RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
0.398 1.72E-127 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.377 6.98E-114 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation