HIPHOP chemogenomics database
YER175C / TMT1 
Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YER175C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.172 | 7.99E-24 | YKL004W | AUR1 | het | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
| 0.126 | 2.20E-13 | YER085C_p | YER085C_p | hom | Putative protein of unknown function |
| 0.119 | 4.08E-12 | YLR406C | RPL31B | hom | Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication |
| 0.117 | 1.49E-11 | YLR327C | TMA10 | hom | Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p; protein abundance increases in response to DNA replication stress |
| 0.113 | 4.80E-11 | YNL266W_d | YNL266W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C |
| 0.111 | 1.23E-10 | YLR285W | NNT1 | hom | S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination |
| 0.109 | 2.72E-10 | YDR367W | KEI1 | het | Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene |
| 0.108 | 3.35E-10 | YER106W | MAM1 | hom | Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle |
| 0.100 | 7.64E-9 | YJR023C_d | YJR023C_d | het | Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing |
| 0.096 | 2.55E-8 | YGL121C | GPG1 | hom | Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing |
| 0.095 | 3.73E-8 | YBR244W | GPX2 | hom | Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress |
| 0.094 | 4.83E-8 | YFR032C-B_p | YFR032C-B_p | hom | Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
| 0.090 | 1.83E-7 | YDR536W | STL1 | hom | Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
| 0.090 | 2.01E-7 | YDR464W | SPP41 | het | Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 |
| 0.087 | 4.57E-7 | YMR141C_d | YMR141C_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |