YFL010C / WWM1

WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL010C / WWM1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.28|P-value:4.73E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.62|P-value:1.30E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-6.37|P-value:8.83E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:3.46E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.12|P-value:1.68E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.68|P-value:1.23E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.29|P-value:5.01E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.08|P-value:9.62E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.71|P-value:9.32E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.10|P-value:9.74E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.25|P-value:5.74E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.48|P-value:3.18E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.24|P-value:5.51E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.89|P-value:4.86E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.87|P-value:4.77E-7 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.41|P-value:2.96E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.55|P-value:2.33E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:-4.14|P-value:1.75E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:5.68|P-value:5.49E-9 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.30|P-value:4.79E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.42|P-value:2.79E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.42|P-value:3.18E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.22|P-value:5.85E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.37|P-value:3.44E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.28|P-value:4.66E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.25|P-value:5.78E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.09|P-value:9.23E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.39|P-value:3.46E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.46|P-value:4.06E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-3.47|P-value:2.64E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.86|P-value:4.94E-7 ID:SGTC_2970|Compound:9090938|FD-Score:4.01|P-value:2.73E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.28|P-value:4.73E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.62|P-value:1.30E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:-6.37|P-value:8.83E-11 ID:SGTC_178|Compound:4092-0806|FD-Score:3.37|P-value:3.46E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.12|P-value:1.68E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.68|P-value:1.23E-6 ID:SGTC_376|Compound:3970-0862|FD-Score:3.61|P-value:1.40E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:-3.29|P-value:5.01E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.08|P-value:9.62E-4 ID:SGTC_761|Compound:k216-0224|FD-Score:3.71|P-value:9.32E-5 ID:SGTC_843|Compound:0310-0051|FD-Score:-3.10|P-value:9.74E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.25|P-value:5.74E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:4.48|P-value:3.18E-6 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.24|P-value:5.51E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-4.89|P-value:4.86E-7 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.21|P-value:5.99E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.87|P-value:4.77E-7 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.41|P-value:2.96E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:-3.47|P-value:2.60E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:4.55|P-value:2.33E-6 ID:SGTC_1387|Compound:3342-1166|FD-Score:-4.14|P-value:1.75E-5 ID:SGTC_1400|Compound:3771-8998|FD-Score:5.68|P-value:5.49E-9 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.30|P-value:4.79E-4 ID:SGTC_1521|Compound:st012942|FD-Score:3.16|P-value:7.17E-4 ID:SGTC_1529|Compound:apigenin|FD-Score:3.16|P-value:7.12E-4 ID:SGTC_1914|Compound:st062367|FD-Score:4.00|P-value:2.85E-5 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.42|P-value:2.79E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-3.42|P-value:3.18E-4 ID:SGTC_2052|Compound:5265182|FD-Score:3.22|P-value:5.85E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.82|P-value:5.87E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.56|P-value:1.69E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.37|P-value:3.44E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.28|P-value:4.66E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.25|P-value:5.78E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.56|P-value:1.70E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.09|P-value:9.23E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.28|P-value:4.72E-4 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.39|P-value:3.46E-4 ID:SGTC_2836|Compound:9010338|FD-Score:-4.46|P-value:4.06E-6 ID:SGTC_2846|Compound:9008642|FD-Score:-3.47|P-value:2.64E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.86|P-value:4.94E-7 ID:SGTC_2970|Compound:9090938|FD-Score:4.01|P-value:2.73E-5

Top fitness defect scores for YFL010C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1400 3771-8998 5.68 51.5 µM 5.49E-9 1 6.74E-9
2 SGTC_1254 0550-0035 4.87 264.0 µM 4.77E-7 6 5.62E-7
3 SGTC_2847 9005661 4.86 71.4 µM 4.94E-7 6 5.81E-7
4 SGTC_184 1494-0393 4.68 24.7 µM 1.23E-6 44 1.44E-6
5 SGTC_1383 3049-0032 4.55 20.7 µM 2.33E-6 60S ribosome export 13 2.70E-6
6 SGTC_862 0452-0056 4.48 10.2 µM 3.18E-6 azole & statin 25 3.67E-6
7 SGTC_181 1447-1644 4.12 8.1 µM 1.68E-5 endomembrane recycling 30 1.90E-5
8 SGTC_2970 9090938 4.01 41.9 µM 2.73E-5 RNA processing & uracil transport 38 3.09E-5
9 SGTC_1914 st062367 4.00 72.6 µM 2.85E-5 19 3.22E-5
10 SGTC_2054 5233173 3.82 129.0 µM 5.87E-5 mitochondrial response to ROS 60 6.59E-5
11 SGTC_761 k216-0224 3.71 480.0 µM 9.32E-5 25 1.04E-4
12 SGTC_163 1327-0036 3.62 7.5 µM 1.30E-4 130 1.45E-4
13 SGTC_376 3970-0862 3.61 59.1 µM 1.40E-4 28 1.55E-4
14 SGTC_2064 5220758 3.56 200.0 µM 1.69E-4 49 1.87E-4
15 SGTC_2351 9026858 3.56 72.3 µM 1.70E-4 RNA processing & uracil transport 37 1.89E-4
16 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.42 70.1 µM 2.79E-4 54 3.08E-4
17 SGTC_1315 1237-0019 3.41 3.7 µM 2.96E-4 17 3.26E-4
18 SGTC_2129 girgensonine 3.37 121.0 µM 3.44E-4 heme biosynthesis & mitochondrial translocase 59 3.79E-4
19 SGTC_178 4092-0806 3.37 87.5 µM 3.46E-4 ergosterol depletion effects on membrane 126 3.81E-4
20 SGTC_2130 NSC 7 3.28 2.5 µM 4.66E-4 copper-dependent oxidative stress 66 5.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 4.59E-10 YNL118C DCP2 het Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.104 2.04E-9 YJR035W RAD26 hom Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein
0.103 2.14E-9 YER089C PTC2 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication
0.102 3.77E-9 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.101 5.25E-9 YLL057C JLP1 hom Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation
0.099 8.58E-9 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.086 6.53E-7 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.084 1.17E-6 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.083 1.72E-6 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.081 2.81E-6 YFL007W BLM10 hom Proteasome activator; binds the core proteasome and stimulates proteasome-mediated protein degradation by inducing gate opening; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
0.081 2.82E-6 YBR258C SHG1 hom Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres
0.078 6.52E-6 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.078 6.52E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.078 6.68E-6 YLR189C ATG26 hom UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
0.078 7.10E-6 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents