YFL028C / CAF16

Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL028C / CAF16

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.56|P-value:9.68E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.97|P-value:9.63E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.00|P-value:1.41E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.31|P-value:2.63E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.98|P-value:9.27E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:4.07|P-value:1.04E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.66|P-value:6.22E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.00|P-value:8.44E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.14|P-value:5.29E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.11|P-value:4.50E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.20|P-value:4.25E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.33|P-value:2.41E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.66|P-value:6.23E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:2.99|P-value:8.55E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.10|P-value:5.71E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.05|P-value:6.92E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.23|P-value:3.84E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.48|P-value:1.44E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.19|P-value:4.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.77|P-value:4.27E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.29|P-value:2.88E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.07|P-value:6.56E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.31|P-value:2.75E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.08|P-value:6.21E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.19|P-value:4.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.15|P-value:5.08E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.12|P-value:5.42E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.85|P-value:2.80E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.75|P-value:4.25E-5 ID:SGTC_2484|Compound:5809818|FD-Score:7.29|P-value:1.15E-14 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.24|P-value:3.49E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.09|P-value:6.00E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.27|P-value:3.22E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.01|P-value:8.16E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.38|P-value:2.25E-6 ID:SGTC_2978|Compound:9011784|FD-Score:-3.15|P-value:5.06E-4 ID:SGTC_2979|Compound:9012552|FD-Score:4.07|P-value:1.03E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-2.99|P-value:9.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.67|P-value:6.11E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.62|P-value:7.90E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.04|P-value:7.13E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.56|P-value:9.68E-5 ID:SGTC_66|Compound:0109-0187|FD-Score:-2.97|P-value:9.63E-4 ID:SGTC_545|Compound:4218-0007|FD-Score:4.00|P-value:1.41E-5 ID:SGTC_551|Compound:k048-0028|FD-Score:3.31|P-value:2.63E-4 ID:SGTC_554|Compound:4483-2211|FD-Score:4.98|P-value:9.27E-8 ID:SGTC_841|Compound:0251-0215|FD-Score:4.07|P-value:1.04E-5 ID:SGTC_995|Compound:3931-2021|FD-Score:3.66|P-value:6.22E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.00|P-value:8.44E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-3.14|P-value:5.29E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:5.11|P-value:4.50E-8 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.20|P-value:4.25E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:3.33|P-value:2.41E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.30|P-value:2.88E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:3.66|P-value:6.23E-5 ID:SGTC_1091|Compound:telmisartan|FD-Score:2.99|P-value:8.55E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.10|P-value:5.71E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.05|P-value:6.92E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-3.23|P-value:3.84E-4 ID:SGTC_1524|Compound:corynanthine|FD-Score:-3.48|P-value:1.44E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.19|P-value:4.19E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.77|P-value:4.27E-5 ID:SGTC_1953|Compound:st076800|FD-Score:3.29|P-value:2.88E-4 ID:SGTC_1955|Compound:wogonin|FD-Score:3.07|P-value:6.56E-4 ID:SGTC_1994|Compound:st072947|FD-Score:-3.31|P-value:2.75E-4 ID:SGTC_1995|Compound:st072814|FD-Score:3.08|P-value:6.21E-4 ID:SGTC_2050|Compound:5263056|FD-Score:-3.19|P-value:4.41E-4 ID:SGTC_2060|Compound:5238662|FD-Score:-3.15|P-value:5.08E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.12|P-value:5.42E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.85|P-value:2.80E-5 ID:SGTC_2291|Compound:7917025|FD-Score:3.75|P-value:4.25E-5 ID:SGTC_2484|Compound:5809818|FD-Score:7.29|P-value:1.15E-14 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.24|P-value:3.49E-4 ID:SGTC_2521|Compound:angolensin|FD-Score:3.09|P-value:6.00E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:-3.27|P-value:3.22E-4 ID:SGTC_2714|Compound:st079313|FD-Score:3.01|P-value:8.16E-4 ID:SGTC_2929|Compound:9013348|FD-Score:4.38|P-value:2.25E-6 ID:SGTC_2978|Compound:9011784|FD-Score:-3.15|P-value:5.06E-4 ID:SGTC_2979|Compound:9012552|FD-Score:4.07|P-value:1.03E-5 ID:SGTC_2980|Compound:9014342|FD-Score:-3.20|P-value:4.18E-4 ID:SGTC_2992|Compound:9074591|FD-Score:3.25|P-value:3.29E-4 ID:SGTC_3223|Compound:9129970|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-2.99|P-value:9.05E-4 ID:SGTC_3301|Compound:9125354|FD-Score:3.05|P-value:6.91E-4 ID:SGTC_3305|Compound:9127027|FD-Score:3.67|P-value:6.11E-5 ID:SGTC_3306|Compound:9127676|FD-Score:-3.62|P-value:7.90E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.04|P-value:7.13E-4

Top fitness defect scores for YFL028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2484 5809818 7.29 12.0 µM 1.15E-14 1 1.50E-13
2 SGTC_1033 k072-0102 5.11 21.3 µM 4.50E-8 60S ribosome export 5 1.64E-7
3 SGTC_554 4483-2211 4.98 187.0 µM 9.27E-8 5 3.18E-7
4 SGTC_2929 9013348 4.38 24.6 µM 2.25E-6 14 5.91E-6
5 SGTC_2979 9012552 4.07 45.5 µM 1.03E-5 6 2.40E-5
6 SGTC_841 0251-0215 4.07 91.2 µM 1.04E-5 72 2.40E-5
7 SGTC_545 4218-0007 4.00 221.0 µM 1.41E-5 26 3.19E-5
8 SGTC_2165 5727197 3.85 32.1 µM 2.80E-5 33 5.99E-5
9 SGTC_2291 7917025 3.75 104.3 µM 4.25E-5 iron homeostasis 58 8.76E-5
10 SGTC_3305 9127027 3.67 53.8 µM 6.11E-5 23 1.22E-4
11 SGTC_995 3931-2021 3.66 34.6 µM 6.22E-5 RPP1 & pyrimidine depletion 29 1.24E-4
12 SGTC_1077 5-fluorocytosine 3.66 377.0 nM 6.23E-5 exosome 23 1.25E-4
13 SGTC_6 0844-0013 3.56 19.8 µM 9.68E-5 132 1.87E-4
14 SGTC_1044 1222-0021 3.33 1.8 µM 2.41E-4 heme biosynthesis & mitochondrial translocase 60 4.31E-4
15 SGTC_551 k048-0028 3.31 34.9 µM 2.63E-4 42 4.67E-4
16 SGTC_1953 st076800 3.29 12.1 µM 2.88E-4 82 5.08E-4
17 SGTC_2992 9074591 3.25 71.4 µM 3.29E-4 31 5.74E-4
18 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.24 3.7 µM 3.49E-4 160 6.06E-4
19 SGTC_3223 9129970 3.22 49.5 µM 3.73E-4 45 6.44E-4
20 SGTC_1673 st016611 3.19 27.3 µM 4.19E-4 81 7.17E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.04E-18 YLL062C MHT1 hom S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
0.130 4.36E-14 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.119 4.57E-12 YCR006C_d YCR006C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.118 7.43E-12 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.116 1.65E-11 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.116 1.67E-11 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.111 1.31E-10 YMR034C_p YMR034C_p hom Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene
0.110 1.97E-10 YKL150W MCR1 hom Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis
0.109 2.49E-10 YKL040C NFU1 hom Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria
0.107 4.50E-10 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.107 6.21E-10 YOR121C_d YOR121C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
0.106 7.15E-10 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.105 8.89E-10 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.100 6.34E-9 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.099 9.72E-9 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication