YFL030W / AGX1

Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL030W / AGX1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.42|P-value:1.42E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.80|P-value:1.65E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.59|P-value:4.48E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.43|P-value:1.37E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.08|P-value:5.36E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-2.95|P-value:7.71E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.46|P-value:1.19E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.34|P-value:1.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.07|P-value:5.01E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-2.99|P-value:6.72E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.96|P-value:6.75E-8 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.28|P-value:2.45E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.77|P-value:2.75E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.82|P-value:2.42E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-2.92|P-value:8.67E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-4.06|P-value:6.83E-6 ID:SGTC_1824|Compound:st053723|FD-Score:3.15|P-value:4.17E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.61|P-value:4.83E-7 ID:SGTC_2005|Compound:4024620|FD-Score:6.06|P-value:5.58E-11 ID:SGTC_2086|Compound:5274770|FD-Score:6.19|P-value:2.28E-11 ID:SGTC_2306|Compound:7482397|FD-Score:-3.64|P-value:4.90E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.88|P-value:8.77E-8 ID:SGTC_2556|Compound:citropten|FD-Score:-3.25|P-value:2.46E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.15|P-value:4.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.51|P-value:9.68E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.24|P-value:3.29E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.42|P-value:1.44E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:7.85E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.18|P-value:3.65E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.94|P-value:1.44E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-2.90|P-value:9.35E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.27|P-value:2.58E-4 ID:SGTC_3191|Compound:9110352|FD-Score:2.99|P-value:7.41E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.42|P-value:1.42E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.80|P-value:1.65E-7 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.59|P-value:4.48E-7 ID:SGTC_553|Compound:k007-0256|FD-Score:3.43|P-value:1.37E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.08|P-value:5.36E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.95|P-value:1.38E-5 ID:SGTC_678|Compound:1218-2179|FD-Score:3.36|P-value:1.78E-4 ID:SGTC_759|Compound:3486-0358|FD-Score:3.69|P-value:4.41E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:2.97|P-value:8.02E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-2.95|P-value:7.71E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.00|P-value:7.27E-4 ID:SGTC_1013|Compound:4112-3890|FD-Score:3.46|P-value:1.19E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-3.34|P-value:1.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.33|P-value:1.99E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.96|P-value:1.28E-5 ID:SGTC_1189|Compound:1431-2119|FD-Score:-3.07|P-value:5.01E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:-2.99|P-value:6.72E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.33|P-value:2.07E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:4.96|P-value:6.75E-8 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.28|P-value:2.45E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:-3.77|P-value:2.75E-5 ID:SGTC_1547|Compound:harmine|FD-Score:3.82|P-value:2.42E-5 ID:SGTC_1770|Compound:st043884|FD-Score:-2.92|P-value:8.67E-4 ID:SGTC_1797|Compound:st048695|FD-Score:-4.06|P-value:6.83E-6 ID:SGTC_1824|Compound:st053723|FD-Score:3.15|P-value:4.17E-4 ID:SGTC_2002|Compound:4023503|FD-Score:4.61|P-value:4.83E-7 ID:SGTC_2005|Compound:4024620|FD-Score:6.06|P-value:5.58E-11 ID:SGTC_2086|Compound:5274770|FD-Score:6.19|P-value:2.28E-11 ID:SGTC_2306|Compound:7482397|FD-Score:-3.64|P-value:4.90E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-4.88|P-value:8.77E-8 ID:SGTC_2556|Compound:citropten|FD-Score:-3.25|P-value:2.46E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.00|P-value:1.06E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.15|P-value:4.13E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.51|P-value:9.68E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.24|P-value:3.29E-6 ID:SGTC_2842|Compound:9000675|FD-Score:3.42|P-value:1.44E-4 ID:SGTC_2844|Compound:9010103|FD-Score:2.98|P-value:7.85E-4 ID:SGTC_3005|Compound:9076496|FD-Score:3.18|P-value:3.65E-4 ID:SGTC_3019|Compound:9081971|FD-Score:3.94|P-value:1.44E-5 ID:SGTC_3094|Compound:9117742|FD-Score:-2.90|P-value:9.35E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.27|P-value:2.58E-4 ID:SGTC_3191|Compound:9110352|FD-Score:2.99|P-value:7.41E-4

Top fitness defect scores for YFL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2086 5274770 6.19 176.6 µM 2.28E-11 5 3.04E-10
2 SGTC_2005 4024620 6.06 188.0 µM 5.58E-11 1 6.70E-10
3 SGTC_1259 0671-0132 4.96 43.0 µM 6.75E-8 6 3.57E-7
4 SGTC_416 estradiol valerate 4.80 100.0 µM 1.65E-7 2 7.88E-7
5 SGTC_2002 4023503 4.61 131.0 µM 4.83E-7 mitochondrial processes 17 2.04E-6
6 SGTC_2795 7780010 4.24 54.5 µM 3.29E-6 22 1.12E-5
7 SGTC_2595 hexamethylquercetagetin 4.00 100.0 µM 1.06E-5 23 3.14E-5
8 SGTC_1127 asiatic acid 3.96 681.4 nM 1.28E-5 22 3.73E-5
9 SGTC_656 4090-1979 3.95 187.0 µM 1.38E-5 17 3.98E-5
10 SGTC_3019 9081971 3.94 49.5 µM 1.44E-5 17 4.13E-5
11 SGTC_1547 harmine 3.82 94.2 µM 2.42E-5 ergosterol biosynthesis 48 6.55E-5
12 SGTC_759 3486-0358 3.69 89.3 µM 4.41E-5 25 1.12E-4
13 SGTC_2781 5567276 3.51 71.4 µM 9.68E-5 74 2.25E-4
14 SGTC_1013 4112-3890 3.46 241.0 µM 1.19E-4 TSC3-RPN4 55 2.70E-4
15 SGTC_553 k007-0256 3.43 45.7 µM 1.37E-4 heme biosynthesis & mitochondrial translocase 39 3.05E-4
16 SGTC_6 0844-0013 3.42 19.8 µM 1.42E-4 148 3.17E-4
17 SGTC_2842 9000675 3.42 19.5 µM 1.44E-4 42 3.19E-4
18 SGTC_678 1218-2179 3.36 85.9 µM 1.78E-4 RNA pol III & RNase P/MRP 9 3.85E-4
19 SGTC_1034 k072-0165 3.33 12.7 µM 1.99E-4 Golgi 44 4.27E-4
20 SGTC_1248 0469-0687 3.33 58.6 µM 2.07E-4 54 4.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.107 5.61E-10 YML003W_p YML003W_p hom Putative protein of unknown function
0.107 6.07E-10 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.105 1.18E-9 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.096 2.75E-8 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.089 2.18E-7 YOR227W HER1 hom Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication
0.089 2.71E-7 YJR079W_p YJR079W_p hom Putative protein of unknown function; mutation results in impaired mitochondrial respiration
0.089 2.68E-7 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.087 4.99E-7 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.085 8.72E-7 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.084 1.13E-6 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.080 3.75E-6 YAR031W PRM9 hom Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family
0.076 1.04E-5 YBR004C GPI18 het Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
0.076 1.08E-5 YLR177W_p YLR177W_p hom Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication
0.076 1.11E-5 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.075 1.40E-5 YGR009C SEC9 het t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog