HIPHOP chemogenomics database
YFL032W_d 
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFL032W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.765 | 0 | YHR079C | IRE1 | hom | Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress |
| 0.731 | 0 | YFL031W | HAC1 | hom | Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress |
| 0.614 | 0 | YML130C | ERO1 | het | Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds |
| 0.357 | 1.12E-101 | YLR292C | SEC72 | hom | Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
| 0.308 | 1.70E-74 | YER019C-A | SBH2 | hom | Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p |
| 0.276 | 8.14E-60 | YMR161W | HLJ1 | hom | Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ |
| 0.269 | 7.64E-57 | YML034C-A_d | YML034C-A_d | hom | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.269 | 1.20E-56 | YPR107C | YTH1 | het | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
| 0.265 | 4.24E-55 | YGL093W | SPC105 | het | Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components |
| 0.264 | 1.15E-54 | YDL045C | FAD1 | het | Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin |
| 0.249 | 1.96E-48 | YML034W | SRC1 | hom | Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance |
| 0.248 | 4.81E-48 | YOR254C | SEC63 | het | Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER |
| 0.244 | 1.63E-46 | YPR064W_d | YPR064W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.235 | 1.60E-43 | YLR379W_d | YLR379W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C |
| 0.231 | 5.10E-42 | YJL155C | FBP26 | hom | Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress |