YFL034W_p

Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL034W / YFL034W

Click on Significant Values for Screen Details ID:SGTC_57|Compound:miconazole|FD-Score:21.60|P-value:4.10E-101 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.66|P-value:1.46E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.17|P-value:8.51E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.31|P-value:2.64E-13 ID:SGTC_172|Compound:1112-0046|FD-Score:4.64|P-value:2.33E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:9.08|P-value:1.43E-19 ID:SGTC_181|Compound:1447-1644|FD-Score:8.50|P-value:2.26E-17 ID:SGTC_193|Compound:1273-0060|FD-Score:5.10|P-value:2.36E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:9.70|P-value:4.57E-22 ID:SGTC_201|Compound:4262-0159|FD-Score:15.20|P-value:1.79E-51 ID:SGTC_207|Compound:4185-0010|FD-Score:42.40|P-value:0 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.65|P-value:1.18E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:19.30|P-value:4.23E-81 ID:SGTC_252|Compound:miconazole|FD-Score:11.00|P-value:8.29E-28 ID:SGTC_254|Compound:nsc-64875|FD-Score:20.90|P-value:5.09E-95 ID:SGTC_256|Compound:clotrimazole|FD-Score:9.63|P-value:8.81E-22 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:11.00|P-value:4.76E-28 ID:SGTC_278|Compound:4092-0821|FD-Score:8.50|P-value:2.29E-17 ID:SGTC_299|Compound:1273-0059|FD-Score:3.20|P-value:7.92E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:12.90|P-value:1.84E-37 ID:SGTC_312|Compound:4092-0653|FD-Score:19.50|P-value:1.10E-82 ID:SGTC_313|Compound:3474-0040|FD-Score:6.15|P-value:6.23E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:17.30|P-value:9.95E-66 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.76E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.44|P-value:3.88E-8 ID:SGTC_447|Compound:ml7|FD-Score:7.64|P-value:2.14E-14 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.38|P-value:1.59E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.48|P-value:2.88E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:11.30|P-value:1.94E-29 ID:SGTC_649|Compound:1123-0311|FD-Score:9.48|P-value:3.58E-21 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.40|P-value:3.90E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:7.05|P-value:1.63E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:19.60|P-value:9.70E-84 ID:SGTC_916|Compound:4466-0038|FD-Score:5.69|P-value:9.32E-9 ID:SGTC_954|Compound:1189-0853|FD-Score:4.99|P-value:4.07E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.04|P-value:2.06E-19 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.30|P-value:1.92E-29 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.85|P-value:8.53E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.44|P-value:9.92E-11 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.53|P-value:2.42E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.29|P-value:5.88E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.38|P-value:4.16E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.81|P-value:1.64E-18 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_1719|Compound:st032227|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:2.47E-43 ID:SGTC_1754|Compound:st042065|FD-Score:9.88|P-value:8.01E-23 ID:SGTC_1760|Compound:st045453|FD-Score:7.56|P-value:4.12E-14 ID:SGTC_1797|Compound:st048695|FD-Score:7.32|P-value:2.33E-13 ID:SGTC_1800|Compound:st050079|FD-Score:6.73|P-value:1.44E-11 ID:SGTC_1801|Compound:st050089|FD-Score:4.87|P-value:7.53E-7 ID:SGTC_1803|Compound:st050068|FD-Score:10.30|P-value:1.01E-24 ID:SGTC_1818|Compound:st052136|FD-Score:5.34|P-value:6.83E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:3.10E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.16|P-value:8.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:31.70|P-value:3.63E-216 ID:SGTC_2008|Compound:4012253|FD-Score:3.29|P-value:5.81E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.02|P-value:3.57E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.96|P-value:4.61E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.24|P-value:6.87E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.60|P-value:4.85E-26 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.39|P-value:5.03E-8 ID:SGTC_2257|Compound:7960413|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.79|P-value:8.95E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.75|P-value:2.96E-22 ID:SGTC_2777|Compound:climbazole|FD-Score:5.16|P-value:1.76E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:13.20|P-value:5.19E-39 ID:SGTC_2790|Compound:5423970|FD-Score:7.15|P-value:7.86E-13 ID:SGTC_2828|Compound:7998861|FD-Score:3.37|P-value:4.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:9.47|P-value:4.05E-21 ID:SGTC_2948|Compound:9070189|FD-Score:10.50|P-value:1.07E-25 ID:SGTC_2991|Compound:9074669|FD-Score:3.34|P-value:4.86E-4 ID:SGTC_3018|Compound:9082602|FD-Score:10.10|P-value:1.19E-23 ID:SGTC_3037|Compound:9091026|FD-Score:6.78|P-value:1.09E-11 ID:SGTC_3044|Compound:9093193|FD-Score:3.28|P-value:5.94E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.05|P-value:3.12E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_3126|Compound:9127922|FD-Score:12.50|P-value:2.06E-35 ID:SGTC_3152|Compound:9099253|FD-Score:7.44|P-value:9.72E-14 ID:SGTC_3308|Compound:9128332|FD-Score:19.00|P-value:4.52E-79 ID:SGTC_3318|Compound:9139014|FD-Score:3.22|P-value:7.39E-4 ID:SGTC_57|Compound:miconazole|FD-Score:21.60|P-value:4.10E-101 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.66|P-value:1.46E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-3.17|P-value:8.51E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:7.31|P-value:2.64E-13 ID:SGTC_172|Compound:1112-0046|FD-Score:4.64|P-value:2.33E-6 ID:SGTC_178|Compound:4092-0806|FD-Score:9.08|P-value:1.43E-19 ID:SGTC_181|Compound:1447-1644|FD-Score:8.50|P-value:2.26E-17 ID:SGTC_193|Compound:1273-0060|FD-Score:5.10|P-value:2.36E-7 ID:SGTC_197|Compound:4544-0043|FD-Score:9.70|P-value:4.57E-22 ID:SGTC_201|Compound:4262-0159|FD-Score:15.20|P-value:1.79E-51 ID:SGTC_207|Compound:4185-0010|FD-Score:42.40|P-value:0 ID:SGTC_217|Compound:ketoconazole|FD-Score:5.65|P-value:1.18E-8 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.23|P-value:7.03E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:19.30|P-value:4.23E-81 ID:SGTC_252|Compound:miconazole|FD-Score:11.00|P-value:8.29E-28 ID:SGTC_254|Compound:nsc-64875|FD-Score:20.90|P-value:5.09E-95 ID:SGTC_256|Compound:clotrimazole|FD-Score:9.63|P-value:8.81E-22 ID:SGTC_260|Compound:nsc-65238|FD-Score:3.55|P-value:2.26E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:11.00|P-value:4.76E-28 ID:SGTC_278|Compound:4092-0821|FD-Score:8.50|P-value:2.29E-17 ID:SGTC_299|Compound:1273-0059|FD-Score:3.20|P-value:7.92E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:12.90|P-value:1.84E-37 ID:SGTC_312|Compound:4092-0653|FD-Score:19.50|P-value:1.10E-82 ID:SGTC_313|Compound:3474-0040|FD-Score:6.15|P-value:6.23E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:17.30|P-value:9.95E-66 ID:SGTC_346|Compound:4513-0042|FD-Score:3.50|P-value:2.76E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:5.44|P-value:3.88E-8 ID:SGTC_447|Compound:ml7|FD-Score:7.64|P-value:2.14E-14 ID:SGTC_449|Compound:xestospongin c|FD-Score:7.38|P-value:1.59E-13 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.48|P-value:2.88E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:11.30|P-value:1.94E-29 ID:SGTC_649|Compound:1123-0311|FD-Score:9.48|P-value:3.58E-21 ID:SGTC_659|Compound:k018-0002|FD-Score:-3.37|P-value:4.34E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:-3.40|P-value:3.90E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:7.05|P-value:1.63E-12 ID:SGTC_788|Compound:1182-0090|FD-Score:19.60|P-value:9.70E-84 ID:SGTC_916|Compound:4466-0038|FD-Score:5.69|P-value:9.32E-9 ID:SGTC_954|Compound:1189-0853|FD-Score:4.99|P-value:4.07E-7 ID:SGTC_1019|Compound:4262-0212|FD-Score:9.04|P-value:2.06E-19 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.30|P-value:1.92E-29 ID:SGTC_1097|Compound:itavastatin|FD-Score:4.85|P-value:8.53E-7 ID:SGTC_1130|Compound:3454-2858|FD-Score:6.44|P-value:9.92E-11 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.53|P-value:2.42E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_1528|Compound:arabinosylhypoxanthine|FD-Score:3.66|P-value:1.53E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.29|P-value:5.88E-4 ID:SGTC_1635|Compound:st007035|FD-Score:3.38|P-value:4.16E-4 ID:SGTC_1672|Compound:st016598|FD-Score:8.81|P-value:1.64E-18 ID:SGTC_1712|Compound:st032288|FD-Score:4.46|P-value:5.30E-6 ID:SGTC_1719|Compound:st032227|FD-Score:3.73|P-value:1.14E-4 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:2.47E-43 ID:SGTC_1754|Compound:st042065|FD-Score:9.88|P-value:8.01E-23 ID:SGTC_1760|Compound:st045453|FD-Score:7.56|P-value:4.12E-14 ID:SGTC_1797|Compound:st048695|FD-Score:7.32|P-value:2.33E-13 ID:SGTC_1800|Compound:st050079|FD-Score:6.73|P-value:1.44E-11 ID:SGTC_1801|Compound:st050089|FD-Score:4.87|P-value:7.53E-7 ID:SGTC_1803|Compound:st050068|FD-Score:10.30|P-value:1.01E-24 ID:SGTC_1818|Compound:st052136|FD-Score:5.34|P-value:6.83E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.23|P-value:6.98E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.06|P-value:3.10E-5 ID:SGTC_1994|Compound:st072947|FD-Score:3.16|P-value:8.99E-4 ID:SGTC_2006|Compound:4011487|FD-Score:31.70|P-value:3.63E-216 ID:SGTC_2008|Compound:4012253|FD-Score:3.29|P-value:5.81E-4 ID:SGTC_2021|Compound:4019055|FD-Score:5.02|P-value:3.57E-7 ID:SGTC_2036|Compound:5160441|FD-Score:3.58|P-value:2.06E-4 ID:SGTC_2136|Compound:5328288|FD-Score:3.96|P-value:4.61E-5 ID:SGTC_2148|Compound:5546263|FD-Score:3.24|P-value:6.87E-4 ID:SGTC_2240|Compound:6690706|FD-Score:3.24|P-value:6.93E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:10.60|P-value:4.85E-26 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.39|P-value:5.03E-8 ID:SGTC_2257|Compound:7960413|FD-Score:3.73|P-value:1.17E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.79|P-value:8.95E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.75|P-value:2.96E-22 ID:SGTC_2777|Compound:climbazole|FD-Score:5.16|P-value:1.76E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:13.20|P-value:5.19E-39 ID:SGTC_2790|Compound:5423970|FD-Score:7.15|P-value:7.86E-13 ID:SGTC_2828|Compound:7998861|FD-Score:3.37|P-value:4.43E-4 ID:SGTC_2896|Compound:9052656|FD-Score:9.47|P-value:4.05E-21 ID:SGTC_2948|Compound:9070189|FD-Score:10.50|P-value:1.07E-25 ID:SGTC_2991|Compound:9074669|FD-Score:3.34|P-value:4.86E-4 ID:SGTC_3018|Compound:9082602|FD-Score:10.10|P-value:1.19E-23 ID:SGTC_3037|Compound:9091026|FD-Score:6.78|P-value:1.09E-11 ID:SGTC_3044|Compound:9093193|FD-Score:3.28|P-value:5.94E-4 ID:SGTC_3045|Compound:9092950|FD-Score:5.05|P-value:3.12E-7 ID:SGTC_3062|Compound:9077494|FD-Score:3.36|P-value:4.57E-4 ID:SGTC_3126|Compound:9127922|FD-Score:12.50|P-value:2.06E-35 ID:SGTC_3152|Compound:9099253|FD-Score:7.44|P-value:9.72E-14 ID:SGTC_3308|Compound:9128332|FD-Score:19.00|P-value:4.52E-79 ID:SGTC_3318|Compound:9139014|FD-Score:3.22|P-value:7.39E-4

Top fitness defect scores for YFL034W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 42.40 4.5 µM 0 endomembrane recycling 1 0
2 SGTC_2006 4011487 31.70 200.0 µM 3.63E-216 endomembrane recycling 1 2.97E-221
3 SGTC_57 miconazole 21.60 162.5 nM 4.10E-101 ergosterol depletion effects on membrane 1 1.77E-103
4 SGTC_254 nsc-64875 20.90 3.8 µM 5.09E-95 ergosterol depletion effects on membrane 2 3.07E-97
5 SGTC_788 1182-0090 19.60 188.0 µM 9.70E-84 endomembrane recycling 4 1.08E-85
6 SGTC_312 4092-0653 19.50 6.8 µM 1.10E-82 ergosterol depletion effects on membrane 1 1.30E-84
7 SGTC_221 trifluoperazine 19.30 10.3 µM 4.23E-81 NEO1-PIK1 12 5.44E-83
8 SGTC_3308 9128332 19.00 17.6 µM 4.52E-79 plasma membrane duress 8 6.49E-81
9 SGTC_320 4092-0846 17.30 5.3 µM 9.95E-66 ergosterol depletion effects on membrane 1 2.96E-67
10 SGTC_201 4262-0159 15.20 12.8 µM 1.79E-51 ergosterol depletion effects on membrane 4 1.16E-52
11 SGTC_1750 st081859 13.90 2.4 µM 2.47E-43 endomembrane recycling 24 2.50E-44
12 SGTC_2778 tioconazole 13.20 65.1 nM 5.19E-39 ergosterol depletion effects on membrane 7 6.64E-40
13 SGTC_308 4092-1169 12.90 104.0 µM 1.84E-37 plasma membrane duress 3 2.56E-38
14 SGTC_3126 9127922 12.50 49.5 µM 2.06E-35 fatty acid desaturase (OLE1) 4 3.21E-36
15 SGTC_1072 oxiconazole 11.30 14.9 nM 1.92E-29 ergosterol depletion effects on membrane 2 4.15E-30
16 SGTC_515 4092-1064 11.30 102.0 µM 1.94E-29 plasma membrane duress 5 4.18E-30
17 SGTC_262 fenpropimorph 11.00 62.5 µM 4.76E-28 ergosterol depletion effects on membrane 2 1.11E-28
18 SGTC_252 miconazole 11.00 1.3 nM 8.29E-28 ergosterol depletion effects on membrane 2 1.96E-28
19 SGTC_2249 haloperidol 10.60 116.4 µM 4.85E-26 ergosterol depletion effects on membrane 10 1.26E-26
20 SGTC_2948 9070189 10.50 9.4 µM 1.07E-25 plasma membrane duress 11 2.83E-26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.773 0 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.669 0 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.643 0 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.626 0 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.615 0 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.613 0 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.607 0 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.592 2.91E-316 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.504 2.55E-215 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.490 5.60E-202 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.471 3.53E-185 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.463 7.06E-177 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.415 9.00E-140 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.408 8.12E-135 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.407 3.41E-134 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth