YFL037W / TUB2

Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria

Zygosity: Heterozygous strain
fixedexpanded
Profile for YFL037W / TUB2

Click on Significant Values for Screen Details ID:SGTC_60|Compound:0986-0278|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.23|P-value:5.18E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:22.30|P-value:5.53E-113 ID:SGTC_212|Compound:3807-4682|FD-Score:9.34|P-value:1.45E-21 ID:SGTC_229|Compound:benomyl|FD-Score:6.35|P-value:5.95E-11 ID:SGTC_296|Compound:1222-0039|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.43|P-value:3.41E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.26|P-value:5.05E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:5.13|P-value:9.66E-8 ID:SGTC_762|Compound:1165-0429|FD-Score:3.58|P-value:1.37E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.49|P-value:2.60E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.21|P-value:6.00E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.21|P-value:5.54E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.47|P-value:2.14E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.20|P-value:5.77E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.11|P-value:1.50E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.45|P-value:2.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.10|P-value:9.06E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.72|P-value:7.95E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.02|P-value:2.27E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.81|P-value:5.38E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.45|P-value:3.52E-6 ID:SGTC_2161|Compound:5662504|FD-Score:3.79|P-value:5.88E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.13|P-value:7.23E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.93|P-value:3.69E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.41|P-value:2.70E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-5.59|P-value:8.36E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.69|P-value:8.99E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.91|P-value:3.61E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:32.10|P-value:1.07E-231 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.88|P-value:4.55E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.21|P-value:6.12E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.71|P-value:9.15E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_2844|Compound:9010103|FD-Score:9.50|P-value:3.14E-22 ID:SGTC_2845|Compound:9003024|FD-Score:-7.03|P-value:6.21E-13 ID:SGTC_2942|Compound:9052777|FD-Score:3.84|P-value:4.77E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.40|P-value:2.79E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.86|P-value:4.88E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.06|P-value:9.28E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-14.80|P-value:3.73E-51 ID:SGTC_3207|Compound:9114163|FD-Score:5.46|P-value:1.51E-8 ID:SGTC_3273|Compound:9137859|FD-Score:3.05|P-value:9.68E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:3.35|P-value:3.28E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.23|P-value:5.18E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:22.30|P-value:5.53E-113 ID:SGTC_212|Compound:3807-4682|FD-Score:9.34|P-value:1.45E-21 ID:SGTC_229|Compound:benomyl|FD-Score:6.35|P-value:5.95E-11 ID:SGTC_296|Compound:1222-0039|FD-Score:3.34|P-value:3.42E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.96|P-value:2.88E-5 ID:SGTC_375|Compound:3970-0961|FD-Score:3.61|P-value:1.22E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:4.43|P-value:3.41E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.27|P-value:4.44E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.26|P-value:5.05E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:5.13|P-value:9.66E-8 ID:SGTC_762|Compound:1165-0429|FD-Score:3.58|P-value:1.37E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.49|P-value:2.60E-6 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.21|P-value:6.00E-4 ID:SGTC_1318|Compound:1280-3875|FD-Score:3.21|P-value:5.54E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.47|P-value:2.14E-4 ID:SGTC_1686|Compound:st019653|FD-Score:3.20|P-value:5.77E-4 ID:SGTC_1713|Compound:st033146|FD-Score:4.11|P-value:1.50E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.45|P-value:2.33E-4 ID:SGTC_1801|Compound:st050089|FD-Score:-3.10|P-value:9.06E-4 ID:SGTC_1942|Compound:st076330|FD-Score:3.72|P-value:7.95E-5 ID:SGTC_1963|Compound:st076565|FD-Score:4.02|P-value:2.27E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.81|P-value:5.38E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.55|P-value:1.53E-4 ID:SGTC_2126|Compound:5251174|FD-Score:-4.45|P-value:3.52E-6 ID:SGTC_2161|Compound:5662504|FD-Score:3.79|P-value:5.88E-5 ID:SGTC_2273|Compound:7815444|FD-Score:3.13|P-value:7.23E-4 ID:SGTC_2345|Compound:9052315|FD-Score:-3.93|P-value:3.69E-5 ID:SGTC_2379|Compound:9035213|FD-Score:3.05|P-value:9.65E-4 ID:SGTC_2479|Compound:5617353|FD-Score:3.41|P-value:2.70E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-5.59|P-value:8.36E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.69|P-value:8.99E-5 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:-4.91|P-value:3.61E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:32.10|P-value:1.07E-231 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.88|P-value:4.55E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:-3.21|P-value:6.12E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.71|P-value:9.15E-5 ID:SGTC_2810|Compound:7959871|FD-Score:3.47|P-value:2.13E-4 ID:SGTC_2844|Compound:9010103|FD-Score:9.50|P-value:3.14E-22 ID:SGTC_2845|Compound:9003024|FD-Score:-7.03|P-value:6.21E-13 ID:SGTC_2942|Compound:9052777|FD-Score:3.84|P-value:4.77E-5 ID:SGTC_2943|Compound:9068529|FD-Score:3.40|P-value:2.79E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.86|P-value:4.88E-5 ID:SGTC_3020|Compound:9089140|FD-Score:3.20|P-value:5.75E-4 ID:SGTC_3030|Compound:9087619|FD-Score:-3.39|P-value:3.16E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.06|P-value:9.28E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-14.80|P-value:3.73E-51 ID:SGTC_3207|Compound:9114163|FD-Score:5.46|P-value:1.51E-8 ID:SGTC_3273|Compound:9137859|FD-Score:3.05|P-value:9.68E-4

Top fitness defect scores for YFL037W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2651 1327-0036 32.10 5.0 µM 1.07E-231 1 3.66E-226 7.92
2 SGTC_163 1327-0036 22.30 7.5 µM 5.53E-113 2 2.85E-110 0.05
3 SGTC_2844 9010103 9.50 26.0 µM 3.14E-22 1 1.06E-21 1.43
4 SGTC_212 3807-4682 9.34 38.8 µM 1.45E-21 tubulin folding & SWR complex 4 4.73E-21 0.19
5 SGTC_229 benomyl 6.35 22.9 µM 5.95E-11 tubulin folding & SWR complex 8 1.07E-10 0.38
6 SGTC_3207 9114163 5.46 49.5 µM 1.51E-8 2 2.36E-8 0.04
7 SGTC_703 3875-0075 5.13 71.8 µM 9.66E-8 1 1.44E-7 0.64
8 SGTC_1119 parthenolide 4.49 318.5 nM 2.60E-6 TSC3-RPN4 7 3.57E-6 0.35
9 SGTC_379 3970-0972 4.43 5.9 µM 3.41E-6 tubulin folding & SWR complex 4 4.65E-6 0.05
10 SGTC_1713 st033146 4.11 12.8 µM 1.50E-5 7 1.97E-5 0.02
11 SGTC_1963 st076565 4.02 50.3 µM 2.27E-5 3 2.95E-5 0.33
12 SGTC_369 0957-0393 3.96 4.5 µM 2.88E-5 cell wall signaling 7 3.72E-5 0.02
13 SGTC_2942 9052777 3.84 62.2 µM 4.77E-5 9 6.09E-5 0.26
14 SGTC_2093 5331342 3.81 194.4 µM 5.38E-5 6 6.84E-5 0.00
15 SGTC_2161 5662504 3.79 8.5 µM 5.88E-5 tubulin folding & SWR complex 6 7.47E-5 0.02
16 SGTC_1942 st076330 3.72 65.2 µM 7.95E-5 6 1.00E-4 0.41
17 SGTC_2514 salinomycin 3.69 42.7 µM 8.99E-5 5 1.13E-4 0.28
18 SGTC_375 3970-0961 3.61 9.3 µM 1.22E-4 tubulin folding & SWR complex 11 1.52E-4 0.07
19 SGTC_762 1165-0429 3.58 115.0 µM 1.37E-4 TSC3-RPN4 5 1.70E-4 0.17
20 SGTC_2098 5376439 3.55 882.5 nM 1.53E-4 7 1.89E-4 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.476 1.74E-189 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.430 7.48E-151 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.410 4.28E-136 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.381 2.24E-116 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.381 4.40E-116 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.367 1.01E-107 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.366 4.04E-107 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.362 1.09E-104 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.348 3.28E-96 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.347 1.88E-95 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.343 7.27E-93 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.340 2.67E-91 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.314 7.75E-78 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.286 4.54E-64 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.284 2.29E-63 YIL061C SNP1 het Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress