HIPHOP chemogenomics database

YFL037W / TUB2

Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria

Zygosity: Heterozygous strain

fixedexpanded
Profile for YFL037W / TUB2

Click on Significant Values for Screen Details

Top fitness defect scores for YFL037W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2651	1327-0036	32.10	5.0 µM	1.07E-231		1	3.66E-226	7.92
2	SGTC_163	1327-0036	22.30	7.5 µM	5.53E-113		2	2.85E-110	0.05
3	SGTC_2844	9010103	9.50	26.0 µM	3.14E-22		1	1.06E-21	1.43
4	SGTC_212	3807-4682	9.34	38.8 µM	1.45E-21	tubulin folding & SWR complex	4	4.73E-21	0.19
5	SGTC_229	benomyl	6.35	22.9 µM	5.95E-11	tubulin folding & SWR complex	8	1.07E-10	0.38
6	SGTC_3207	9114163	5.46	49.5 µM	1.51E-8		2	2.36E-8	0.04
7	SGTC_703	3875-0075	5.13	71.8 µM	9.66E-8		1	1.44E-7	0.64
8	SGTC_1119	parthenolide	4.49	318.5 nM	2.60E-6	TSC3-RPN4	7	3.57E-6	0.35
9	SGTC_379	3970-0972	4.43	5.9 µM	3.41E-6	tubulin folding & SWR complex	4	4.65E-6	0.05
10	SGTC_1713	st033146	4.11	12.8 µM	1.50E-5		7	1.97E-5	0.02
11	SGTC_1963	st076565	4.02	50.3 µM	2.27E-5		3	2.95E-5	0.33
12	SGTC_369	0957-0393	3.96	4.5 µM	2.88E-5	cell wall signaling	7	3.72E-5	0.02
13	SGTC_2942	9052777	3.84	62.2 µM	4.77E-5		9	6.09E-5	0.26
14	SGTC_2093	5331342	3.81	194.4 µM	5.38E-5		6	6.84E-5	0.00
15	SGTC_2161	5662504	3.79	8.5 µM	5.88E-5	tubulin folding & SWR complex	6	7.47E-5	0.02
16	SGTC_1942	st076330	3.72	65.2 µM	7.95E-5		6	1.00E-4	0.41
17	SGTC_2514	salinomycin	3.69	42.7 µM	8.99E-5		5	1.13E-4	0.28
18	SGTC_375	3970-0961	3.61	9.3 µM	1.22E-4	tubulin folding & SWR complex	11	1.52E-4	0.07
19	SGTC_762	1165-0429	3.58	115.0 µM	1.37E-4	TSC3-RPN4	5	1.70E-4	0.17
20	SGTC_2098	5376439	3.55	882.5 nM	1.53E-4		7	1.89E-4	0.18

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.476	1.74E-189	YJL019W	MPS3	het	Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.430	7.48E-151	YIR008C	PRI1	het	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.410	4.28E-136	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.381	2.24E-116	YJL005W	CYR1	het	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.381	4.40E-116	YBL034C	STU1	het	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.367	1.01E-107	YIL019W	FAF1	het	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.366	4.04E-107	YIL022W	TIM44	het	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.362	1.09E-104	YIR012W	SQT1	het	Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.348	3.28E-96	YOR297C	TIM18	hom	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.347	1.88E-95	YDR381W	YRA1	het	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.343	7.27E-93	YER052C	HOM3	hom	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.340	2.67E-91	YGR193C	PDX1	hom	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.314	7.75E-78	YNL239W	LAP3	hom	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.286	4.54E-64	YCR053W	THR4	hom	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.284	2.29E-63	YIL061C	SNP1	het	Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress