YFL041W / FET5

Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL041W / FET5

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.48|P-value:5.02E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.96|P-value:4.74E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.42|P-value:3.85E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.34|P-value:9.33E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:2.81|P-value:8.43E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.93|P-value:5.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.99|P-value:2.90E-15 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.97|P-value:4.47E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.27|P-value:1.28E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.10|P-value:2.29E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.75|P-value:1.39E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.41|P-value:6.93E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.79|P-value:1.15E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.96|P-value:4.63E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.27|P-value:1.30E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.69|P-value:1.87E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.69|P-value:1.90E-5 ID:SGTC_2030|Compound:5175110|FD-Score:4.29|P-value:8.12E-7 ID:SGTC_2034|Compound:5197015|FD-Score:3.64|P-value:2.35E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.78|P-value:1.17E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.95|P-value:4.83E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-2.78|P-value:9.58E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.92|P-value:5.42E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.12|P-value:2.43E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.46|P-value:2.53E-13 ID:SGTC_2840|Compound:9008771|FD-Score:-3.65|P-value:2.30E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.26|P-value:2.00E-9 ID:SGTC_2920|Compound:7982904|FD-Score:-6.54|P-value:1.32E-13 ID:SGTC_2923|Compound:7992654|FD-Score:-3.33|P-value:9.84E-5 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:1.78E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-4.69|P-value:7.94E-8 ID:SGTC_2955|Compound:9076254|FD-Score:-5.58|P-value:2.28E-10 ID:SGTC_2962|Compound:9082311|FD-Score:2.98|P-value:4.39E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.87|P-value:6.67E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-6.32|P-value:7.81E-13 ID:SGTC_3216|Compound:9129716|FD-Score:-5.92|P-value:1.79E-11 ID:SGTC_3330|Compound:9141424|FD-Score:-3.17|P-value:1.99E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:-3.08|P-value:2.89E-4 ID:SGTC_379|Compound:3970-0972|FD-Score:3.48|P-value:5.02E-5 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:2.94|P-value:4.98E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:-2.96|P-value:4.74E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-4.42|P-value:3.85E-7 ID:SGTC_669|Compound:0108-0021|FD-Score:3.34|P-value:9.33E-5 ID:SGTC_757|Compound:1066-0008|FD-Score:2.81|P-value:8.43E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:2.93|P-value:5.36E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-6.99|P-value:2.90E-15 ID:SGTC_1211|Compound:1056-0033|FD-Score:2.97|P-value:4.47E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.27|P-value:1.28E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-4.10|P-value:2.29E-6 ID:SGTC_1377|Compound:2944-0135|FD-Score:-3.75|P-value:1.39E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.41|P-value:6.93E-5 ID:SGTC_1737|Compound:st035557|FD-Score:-3.79|P-value:1.15E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.96|P-value:4.63E-4 ID:SGTC_1756|Compound:st041558|FD-Score:3.27|P-value:1.30E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.69|P-value:1.87E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.69|P-value:1.90E-5 ID:SGTC_2030|Compound:5175110|FD-Score:4.29|P-value:8.12E-7 ID:SGTC_2034|Compound:5197015|FD-Score:3.64|P-value:2.35E-5 ID:SGTC_2040|Compound:5100729|FD-Score:3.78|P-value:1.17E-5 ID:SGTC_2046|Compound:4110841|FD-Score:2.95|P-value:4.83E-4 ID:SGTC_2084|Compound:5306078|FD-Score:-2.78|P-value:9.58E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-2.92|P-value:5.42E-4 ID:SGTC_2831|Compound:7999036|FD-Score:-3.12|P-value:2.43E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-6.46|P-value:2.53E-13 ID:SGTC_2840|Compound:9008771|FD-Score:-3.65|P-value:2.30E-5 ID:SGTC_2917|Compound:7979103|FD-Score:5.26|P-value:2.00E-9 ID:SGTC_2920|Compound:7982904|FD-Score:-6.54|P-value:1.32E-13 ID:SGTC_2923|Compound:7992654|FD-Score:-3.33|P-value:9.84E-5 ID:SGTC_2941|Compound:9056145|FD-Score:4.15|P-value:1.78E-6 ID:SGTC_2954|Compound:9074818|FD-Score:-4.69|P-value:7.94E-8 ID:SGTC_2955|Compound:9076254|FD-Score:-5.58|P-value:2.28E-10 ID:SGTC_2962|Compound:9082311|FD-Score:2.98|P-value:4.39E-4 ID:SGTC_3201|Compound:9113999|FD-Score:2.87|P-value:6.67E-4 ID:SGTC_3213|Compound:9129884|FD-Score:-6.32|P-value:7.81E-13 ID:SGTC_3216|Compound:9129716|FD-Score:-5.92|P-value:1.79E-11 ID:SGTC_3330|Compound:9141424|FD-Score:-3.17|P-value:1.99E-4

Top fitness defect scores for YFL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2917 7979103 5.26 53.8 µM 2.00E-9 8 7.09E-8
2 SGTC_2030 5175110 4.29 200.0 µM 8.12E-7 Golgi 21 8.99E-6
3 SGTC_2941 9056145 4.15 11.2 µM 1.78E-6 14 1.69E-5
4 SGTC_2040 5100729 3.78 123.0 µM 1.17E-5 45 7.77E-5
5 SGTC_1779 st039427 3.69 55.0 µM 1.87E-5 33 1.13E-4
6 SGTC_2034 5197015 3.64 53.1 µM 2.35E-5 SWF1 & branched chain AA biosynthesis 31 1.37E-4
7 SGTC_379 3970-0972 3.48 5.9 µM 5.02E-5 tubulin folding & SWR complex 52 2.52E-4
8 SGTC_1725 st036284 3.41 20.6 µM 6.93E-5 53 3.27E-4
9 SGTC_669 0108-0021 3.34 26.2 µM 9.33E-5 fatty acid desaturase (OLE1) 123 4.17E-4
10 SGTC_1756 st041558 3.27 35.5 µM 1.30E-4 24 5.46E-4
11 SGTC_2962 9082311 2.98 13.2 µM 4.39E-4 67 0.00146
12 SGTC_1211 1056-0033 2.97 32.3 µM 4.47E-4 35 0.00149
13 SGTC_1740 st038286 2.96 13.2 µM 4.63E-4 78 0.00153
14 SGTC_2046 4110841 2.95 106.0 µM 4.83E-4 iron homeostasis 67 0.00158
15 SGTC_434 1-hexadecyl-2-methylglycero-3 PC 2.94 8.0 µM 4.98E-4 73 0.00162
16 SGTC_1008 4106-0037 2.93 6.0 µM 5.36E-4 PDR1 52 0.00172
17 SGTC_3201 9113999 2.87 49.5 µM 6.67E-4 88 0.00206
18 SGTC_757 1066-0008 2.81 322.0 µM 8.43E-4 Golgi 75 0.00249
19 SGTC_2013 4024628 2.74 200.0 µM 0.00111 123 0.00311
20 SGTC_2048 5246248 2.71 200.0 µM 0.00121 47 0.00333

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.257 1.14E-51 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.240 2.64E-45 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.213 1.01E-35 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.195 5.75E-30 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.187 8.96E-28 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.178 2.31E-25 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.178 2.43E-25 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.177 6.09E-25 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.176 7.73E-25 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.176 1.00E-24 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.176 9.78E-25 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.172 8.15E-24 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.172 8.47E-24 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.170 3.68E-23 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.167 1.79E-22 YNL042W BOP3 hom Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury