YFL046W_p / FMP32

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL046W / FMP32

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.13|P-value:4.30E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.53|P-value:8.58E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:3.26|P-value:2.58E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-2.98|P-value:5.97E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.66|P-value:3.26E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:-2.86|P-value:9.09E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-2.87|P-value:9.00E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.84|P-value:2.11E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.07|P-value:4.21E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.96|P-value:8.08E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.08|P-value:3.98E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.20|P-value:3.26E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.27|P-value:2.62E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.05|P-value:7.71E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.53|P-value:6.32E-5 ID:SGTC_1523|Compound:st012844|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.96|P-value:8.18E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:6.10E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.19|P-value:1.42E-8 ID:SGTC_2710|Compound:st078562|FD-Score:-2.87|P-value:8.98E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.03|P-value:6.23E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.12|P-value:3.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.57|P-value:7.05E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.69|P-value:4.14E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.85|P-value:1.48E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.42|P-value:1.01E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.13|P-value:4.30E-4 ID:SGTC_523|Compound:1934-0222|FD-Score:3.53|P-value:8.58E-5 ID:SGTC_555|Compound:4296-0685|FD-Score:3.26|P-value:2.58E-4 ID:SGTC_559|Compound:1550-0661|FD-Score:-2.98|P-value:5.97E-4 ID:SGTC_560|Compound:2332-1943|FD-Score:4.66|P-value:3.26E-7 ID:SGTC_575|Compound:k072-0246|FD-Score:-2.86|P-value:9.09E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:-2.87|P-value:9.00E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:3.84|P-value:2.11E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.07|P-value:4.21E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:2.96|P-value:8.08E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.08|P-value:3.98E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.40|P-value:1.49E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:3.20|P-value:3.26E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.45|P-value:1.20E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.27|P-value:2.62E-6 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.28|P-value:2.39E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.05|P-value:7.71E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:-3.53|P-value:6.32E-5 ID:SGTC_1523|Compound:st012844|FD-Score:2.97|P-value:7.79E-4 ID:SGTC_1607|Compound:st000305|FD-Score:2.96|P-value:8.18E-4 ID:SGTC_2144|Compound:5628481|FD-Score:3.61|P-value:6.10E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.19|P-value:1.42E-8 ID:SGTC_2710|Compound:st078562|FD-Score:-2.87|P-value:8.98E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.03|P-value:6.23E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.12|P-value:3.50E-4 ID:SGTC_3143|Compound:9086658|FD-Score:3.12|P-value:4.43E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.57|P-value:7.05E-5 ID:SGTC_3221|Compound:9128209|FD-Score:3.69|P-value:4.14E-5 ID:SGTC_3234|Compound:9132280|FD-Score:-3.85|P-value:1.48E-5 ID:SGTC_3240|Compound:9133527|FD-Score:-3.42|P-value:1.01E-4

Top fitness defect scores for YFL046W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.19 3.7 µM 1.42E-8 27 1.03E-7
2 SGTC_560 2332-1943 4.66 155.0 µM 3.26E-7 1 1.60E-6
3 SGTC_1170 0310-0127 4.27 64.8 µM 2.62E-6 17 9.88E-6
4 SGTC_1350 1495-0454 4.05 146.0 µM 7.71E-6 23 2.54E-5
5 SGTC_789 1309-1135 3.84 70.6 µM 2.11E-5 ERG2 32 6.15E-5
6 SGTC_3221 9128209 3.69 49.5 µM 4.14E-5 19 1.11E-4
7 SGTC_2144 5628481 3.61 200.0 µM 6.10E-5 ERG2 35 1.56E-4
8 SGTC_3165 9101544 3.57 49.5 µM 7.05E-5 18 1.77E-4
9 SGTC_523 1934-0222 3.53 13.7 µM 8.58E-5 42 2.11E-4
10 SGTC_1159 4092-0538 3.45 61.2 µM 1.20E-4 49 2.83E-4
11 SGTC_1139 k015-0024 3.40 46.9 µM 1.49E-4 PDR1 24 3.41E-4
12 SGTC_1192 1488-0095 3.28 21.4 µM 2.39E-4 36 5.18E-4
13 SGTC_555 4296-0685 3.26 37.0 µM 2.58E-4 ergosterol biosynthesis 29 5.55E-4
14 SGTC_1148 3909-7663 3.20 27.7 µM 3.26E-4 41 6.81E-4
15 SGTC_6 0844-0013 3.13 19.8 µM 4.30E-4 182 8.68E-4
16 SGTC_3143 9086658 3.12 49.5 µM 4.43E-4 96 8.92E-4
17 SGTC_2408 sulbentine 3.09 18.4 µM 5.06E-4 89 0.00100
18 SGTC_2909 7941780 3.03 10.5 µM 6.23E-4 51 0.00120
19 SGTC_1523 st012844 2.97 44.7 µM 7.79E-4 60S ribosome export 71 0.00147
20 SGTC_1109 tnp00067 2.96 928.3 nM 8.08E-4 50 0.00151

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.188 4.00E-28 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.180 8.00E-26 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.165 5.80E-22 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.157 4.97E-20 YDR051C DET1 hom Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel
0.152 7.39E-19 YHR021W-A_p ECM12_p hom Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity
0.143 9.41E-17 YDL029W ARP2 het Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
0.141 2.46E-16 YOR155C ISN1 hom Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms
0.138 8.28E-16 YGR236C SPG1 hom Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.133 8.42E-15 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.132 1.90E-14 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.130 4.50E-14 YKR009C FOX2 hom Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
0.130 4.79E-14 YMR239C RNT1 het Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
0.129 7.45E-14 YKR069W MET1 hom S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
0.128 1.05E-13 YLR026C SED5 het cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
0.125 3.44E-13 YOR218C_d YOR218C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W