YFL048C / EMP47

Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL048C / EMP47

Click on Significant Values for Screen Details ID:SGTC_159|Compound:3970-0959|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.25|P-value:6.39E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.18|P-value:5.69E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.21|P-value:4.78E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.82|P-value:1.26E-9 ID:SGTC_424|Compound:splitomicin|FD-Score:4.15|P-value:1.08E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.05|P-value:1.55E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.42|P-value:2.93E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.09|P-value:7.70E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.38|P-value:3.66E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:3.36|P-value:2.87E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.49|P-value:1.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.71|P-value:7.26E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.15|P-value:6.32E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.87|P-value:3.50E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-4.25|P-value:6.21E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:3.97|P-value:2.38E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.43|P-value:2.24E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.75|P-value:6.19E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.21|P-value:7.98E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.55|P-value:1.39E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.82|P-value:4.40E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:4.46E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.35|P-value:2.97E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.83|P-value:3.77E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:6.67E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.68|P-value:7.66E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.14|P-value:6.61E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.09|P-value:7.77E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.89|P-value:3.40E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-6.22|P-value:8.63E-11 ID:SGTC_2125|Compound:5246583|FD-Score:5.29|P-value:3.04E-8 ID:SGTC_2126|Compound:5251174|FD-Score:3.48|P-value:1.81E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.47|P-value:1.79E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.83|P-value:4.35E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.13|P-value:1.16E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-3.27|P-value:3.90E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.13|P-value:6.57E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.41|P-value:2.30E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.28|P-value:3.71E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.48|P-value:1.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.06|P-value:1.59E-5 ID:SGTC_2825|Compound:7998094|FD-Score:5.70|P-value:2.58E-9 ID:SGTC_2995|Compound:9067767|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.15|P-value:9.95E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.13|P-value:6.88E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.53|P-value:1.62E-6 ID:SGTC_3262|Compound:9137218|FD-Score:3.50|P-value:1.68E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.90|P-value:3.12E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.98|P-value:2.15E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.02|P-value:1.95E-5 ID:SGTC_166|Compound:k072-0058|FD-Score:-4.25|P-value:6.39E-6 ID:SGTC_249|Compound:wiskostatin|FD-Score:3.18|P-value:5.69E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:-3.21|P-value:4.78E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.82|P-value:1.26E-9 ID:SGTC_424|Compound:splitomicin|FD-Score:4.15|P-value:1.08E-5 ID:SGTC_430|Compound:0958-0115|FD-Score:-4.05|P-value:1.55E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.42|P-value:2.93E-6 ID:SGTC_589|Compound:1227-0070|FD-Score:3.09|P-value:7.70E-4 ID:SGTC_602|Compound:3130-1533|FD-Score:4.38|P-value:3.66E-6 ID:SGTC_621|Compound:3584-0052|FD-Score:3.36|P-value:2.87E-4 ID:SGTC_635|Compound:k038-0028|FD-Score:3.45|P-value:2.04E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:-3.49|P-value:1.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.10|P-value:7.50E-4 ID:SGTC_662|Compound:k832-1615|FD-Score:3.71|P-value:7.26E-5 ID:SGTC_725|Compound:1497-0963|FD-Score:3.15|P-value:6.32E-4 ID:SGTC_814|Compound:3342-0569|FD-Score:-3.87|P-value:3.50E-5 ID:SGTC_821|Compound:1114-0266|FD-Score:-4.25|P-value:6.21E-6 ID:SGTC_828|Compound:2074-0507|FD-Score:3.97|P-value:2.38E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:3.43|P-value:2.24E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.75|P-value:6.19E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:4.21|P-value:7.98E-6 ID:SGTC_1007|Compound:4101-0031|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.55|P-value:1.39E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.82|P-value:4.40E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.63|P-value:1.01E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:4.46E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:3.35|P-value:2.97E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:4.83|P-value:3.77E-7 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.12|P-value:6.67E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.68|P-value:7.66E-5 ID:SGTC_1691|Compound:st019933|FD-Score:3.14|P-value:6.61E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.09|P-value:7.77E-4 ID:SGTC_1997|Compound:st073024|FD-Score:3.89|P-value:3.40E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-6.22|P-value:8.63E-11 ID:SGTC_2125|Compound:5246583|FD-Score:5.29|P-value:3.04E-8 ID:SGTC_2126|Compound:5251174|FD-Score:3.48|P-value:1.81E-4 ID:SGTC_2134|Compound:5324836|FD-Score:-3.47|P-value:1.79E-4 ID:SGTC_2325|Compound:6158266|FD-Score:3.83|P-value:4.35E-5 ID:SGTC_2464|Compound:5717415|FD-Score:4.13|P-value:1.16E-5 ID:SGTC_2465|Compound:5809242|FD-Score:-3.27|P-value:3.90E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.13|P-value:6.57E-4 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:-3.41|P-value:2.30E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.28|P-value:3.71E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.28|P-value:3.97E-4 ID:SGTC_2678|Compound:equilin|FD-Score:4.16|P-value:1.01E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.48|P-value:1.86E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.15|P-value:6.28E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.06|P-value:1.59E-5 ID:SGTC_2825|Compound:7998094|FD-Score:5.70|P-value:2.58E-9 ID:SGTC_2995|Compound:9067767|FD-Score:-3.10|P-value:7.30E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-4.15|P-value:9.95E-6 ID:SGTC_3208|Compound:9114115|FD-Score:3.13|P-value:6.88E-4 ID:SGTC_3236|Compound:9132701|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_3259|Compound:9138485|FD-Score:-4.53|P-value:1.62E-6 ID:SGTC_3262|Compound:9137218|FD-Score:3.50|P-value:1.68E-4 ID:SGTC_3268|Compound:9137683|FD-Score:-3.90|P-value:3.12E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.98|P-value:2.15E-5

Top fitness defect scores for YFL048C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_358 0075-0058 5.82 9.4 µM 1.26E-9 19 3.00E-9
2 SGTC_2825 7998094 5.70 58.4 µM 2.58E-9 fatty acid desaturase (OLE1) 10 5.95E-9
3 SGTC_2125 5246583 5.29 200.0 µM 3.04E-8 tubulin folding & SWR complex 21 6.22E-8
4 SGTC_1344 1488-0097 4.83 29.1 µM 3.77E-7 8 6.86E-7
5 SGTC_535 2293-4129 4.42 48.2 µM 2.93E-6 NEO1 51 4.85E-6
6 SGTC_602 3130-1533 4.38 38.1 µM 3.66E-6 10 6.00E-6
7 SGTC_849 0386-0493 4.21 241.0 µM 7.98E-6 13 1.26E-5
8 SGTC_2678 equilin 4.16 100.0 µM 1.01E-5 19 1.58E-5
9 SGTC_424 splitomicin 4.15 100.0 mM 1.08E-5 19 1.69E-5
10 SGTC_2464 5717415 4.13 7.7 µM 1.16E-5 13 1.80E-5
11 SGTC_2823 7987624 4.06 58.4 µM 1.59E-5 26 2.43E-5
12 SGTC_159 3970-0959 4.02 50.0 µM 1.95E-5 73 2.95E-5
13 SGTC_828 2074-0507 3.97 139.0 µM 2.38E-5 RPP1 & pyrimidine depletion 24 3.57E-5
14 SGTC_1997 st073024 3.89 93.8 µM 3.40E-5 10 5.02E-5
15 SGTC_2325 6158266 3.83 200.0 µM 4.35E-5 26 6.36E-5
16 SGTC_844 0330-0132 3.75 15.3 µM 6.19E-5 19 8.90E-5
17 SGTC_662 k832-1615 3.71 104.0 µM 7.26E-5 23 1.04E-4
18 SGTC_1183 1254-0324 3.63 198.0 µM 1.01E-4 30 1.42E-4
19 SGTC_1007 4101-0031 3.60 70.0 µM 1.13E-4 27 1.58E-4
20 SGTC_1008 4106-0037 3.55 6.0 µM 1.39E-4 PDR1 29 1.93E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.150 2.97E-18 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.146 2.38E-17 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.121 1.90E-12 YJR078W BNA2 hom Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.121 2.01E-12 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.118 6.08E-12 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.116 1.63E-11 YHR121W LSM12 hom Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
0.115 1.99E-11 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.113 5.24E-11 YBR144C_d YBR144C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.113 5.51E-11 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.112 6.77E-11 YDR330W UBX5 hom UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.111 1.02E-10 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.111 1.34E-10 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.110 1.94E-10 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.108 3.50E-10 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.107 5.05E-10 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene