HIPHOP chemogenomics database

YFL048C / EMP47

Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport

Zygosity: Homozygous strain

fixedexpanded
Profile for YFL048C / EMP47

Click on Significant Values for Screen Details

Top fitness defect scores for YFL048C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_358	0075-0058	5.82	9.4 µM	1.26E-9		19	3.00E-9
2	SGTC_2825	7998094	5.70	58.4 µM	2.58E-9	fatty acid desaturase (OLE1)	10	5.95E-9
3	SGTC_2125	5246583	5.29	200.0 µM	3.04E-8	tubulin folding & SWR complex	21	6.22E-8
4	SGTC_1344	1488-0097	4.83	29.1 µM	3.77E-7		8	6.86E-7
5	SGTC_535	2293-4129	4.42	48.2 µM	2.93E-6	NEO1	51	4.85E-6
6	SGTC_602	3130-1533	4.38	38.1 µM	3.66E-6		10	6.00E-6
7	SGTC_849	0386-0493	4.21	241.0 µM	7.98E-6		13	1.26E-5
8	SGTC_2678	equilin	4.16	100.0 µM	1.01E-5		19	1.58E-5
9	SGTC_424	splitomicin	4.15	100.0 mM	1.08E-5		19	1.69E-5
10	SGTC_2464	5717415	4.13	7.7 µM	1.16E-5		13	1.80E-5
11	SGTC_2823	7987624	4.06	58.4 µM	1.59E-5		26	2.43E-5
12	SGTC_159	3970-0959	4.02	50.0 µM	1.95E-5		73	2.95E-5
13	SGTC_828	2074-0507	3.97	139.0 µM	2.38E-5	RPP1 & pyrimidine depletion	24	3.57E-5
14	SGTC_1997	st073024	3.89	93.8 µM	3.40E-5		10	5.02E-5
15	SGTC_2325	6158266	3.83	200.0 µM	4.35E-5		26	6.36E-5
16	SGTC_844	0330-0132	3.75	15.3 µM	6.19E-5		19	8.90E-5
17	SGTC_662	k832-1615	3.71	104.0 µM	7.26E-5		23	1.04E-4
18	SGTC_1183	1254-0324	3.63	198.0 µM	1.01E-4		30	1.42E-4
19	SGTC_1007	4101-0031	3.60	70.0 µM	1.13E-4		27	1.58E-4
20	SGTC_1008	4106-0037	3.55	6.0 µM	1.39E-4	PDR1	29	1.93E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.150	2.97E-18	YIL107C	PFK26	hom	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.146	2.38E-17	YDL222C	FMP45	hom	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.121	1.90E-12	YJR078W	BNA2	hom	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp
0.121	2.01E-12	YOR377W	ATF1	hom	Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.118	6.08E-12	YDL230W	PTP1	hom	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.116	1.63E-11	YHR121W	LSM12	hom	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress
0.115	1.99E-11	YBR274W	CHK1	hom	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.113	5.24E-11	YBR144C_d	YBR144C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene
0.113	5.51E-11	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.112	6.77E-11	YDR330W	UBX5	hom	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
0.111	1.02E-10	YGL110C	CUE3	hom	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.111	1.34E-10	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.110	1.94E-10	YLR179C	YLR179C	hom	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.108	3.50E-10	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.107	5.05E-10	YDL176W	YDL176W	hom	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene