YFL050C / ALR2

Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL050C / ALR2

Click on Significant Values for Screen Details ID:SGTC_146|Compound:3448-8650|FD-Score:3.94|P-value:7.07E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:4.89|P-value:1.12E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:4.29|P-value:1.73E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:-3.23|P-value:7.96E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.57|P-value:2.43E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.42|P-value:4.81E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.27|P-value:7.05E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.25|P-value:8.48E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.30|P-value:7.36E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.34|P-value:6.26E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.35|P-value:6.23E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.85|P-value:9.89E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.87|P-value:9.21E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.69|P-value:1.83E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.76|P-value:1.24E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.16|P-value:2.87E-5 ID:SGTC_2355|Compound:9061122|FD-Score:-3.37|P-value:5.07E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.30|P-value:1.61E-5 ID:SGTC_2556|Compound:citropten|FD-Score:5.95|P-value:4.35E-9 ID:SGTC_2695|Compound:st077686|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.31|P-value:7.06E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.68|P-value:1.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.21|P-value:9.93E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.43|P-value:4.05E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.74|P-value:1.34E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.22|P-value:8.45E-4 ID:SGTC_146|Compound:3448-8650|FD-Score:3.94|P-value:7.07E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:4.89|P-value:1.12E-6 ID:SGTC_165|Compound:k038-0023|FD-Score:4.29|P-value:1.73E-5 ID:SGTC_465|Compound:cgp-37157|FD-Score:-3.23|P-value:7.96E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:-3.57|P-value:2.43E-4 ID:SGTC_661|Compound:1304-0007|FD-Score:3.42|P-value:4.81E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:-3.27|P-value:7.05E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:3.55|P-value:3.09E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.57|P-value:2.87E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.25|P-value:8.48E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.30|P-value:7.36E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.34|P-value:6.26E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.35|P-value:6.23E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.29|P-value:7.58E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.28|P-value:1.74E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:3.85|P-value:9.89E-5 ID:SGTC_1841|Compound:st054148|FD-Score:3.87|P-value:9.21E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.69|P-value:1.83E-4 ID:SGTC_2079|Compound:5212404|FD-Score:-3.76|P-value:1.24E-4 ID:SGTC_2261|Compound:9010538|FD-Score:4.16|P-value:2.87E-5 ID:SGTC_2355|Compound:9061122|FD-Score:-3.37|P-value:5.07E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.30|P-value:1.61E-5 ID:SGTC_2556|Compound:citropten|FD-Score:5.95|P-value:4.35E-9 ID:SGTC_2695|Compound:st077686|FD-Score:3.35|P-value:6.14E-4 ID:SGTC_2850|Compound:9015429|FD-Score:3.31|P-value:7.06E-4 ID:SGTC_3028|Compound:9087778|FD-Score:3.68|P-value:1.93E-4 ID:SGTC_3078|Compound:9116413|FD-Score:3.21|P-value:9.93E-4 ID:SGTC_3103|Compound:9120822|FD-Score:-3.43|P-value:4.05E-4 ID:SGTC_3146|Compound:9095609|FD-Score:-3.74|P-value:1.34E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-3.22|P-value:8.45E-4

Top fitness defect scores for YFL050C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2556 citropten 5.95 84.6 µM 4.35E-9 4 1.36E-9
2 SGTC_155 k072-0202 4.89 43.6 µM 1.12E-6 10 4.96E-7
3 SGTC_2467 5474540 4.30 200.0 µM 1.61E-5 10 8.45E-6
4 SGTC_165 k038-0023 4.29 64.4 µM 1.73E-5 ubiquinone biosynthesis & proteasome 64 9.10E-6
5 SGTC_1341 1486-1360 4.28 280.0 µM 1.74E-5 15 9.18E-6
6 SGTC_2261 9010538 4.16 184.7 µM 2.87E-5 16 1.56E-5
7 SGTC_146 3448-8650 3.94 53.1 µM 7.07E-5 NEO1-PIK1 138 4.07E-5
8 SGTC_1841 st054148 3.87 70.0 µM 9.21E-5 12 5.40E-5
9 SGTC_1575 cyproterone acetate 3.85 48.0 µM 9.89E-5 24 5.82E-5
10 SGTC_1892 st058411 3.69 7.4 µM 1.83E-4 31 1.12E-4
11 SGTC_3028 9087778 3.68 49.5 µM 1.93E-4 21 1.19E-4
12 SGTC_1003 4049-0218 3.57 100.0 µM 2.87E-4 31 1.80E-4
13 SGTC_952 1185-0122 3.55 232.0 µM 3.09E-4 31 1.95E-4
14 SGTC_661 1304-0007 3.42 33.6 µM 4.81E-4 33 3.12E-4
15 SGTC_2695 st077686 3.35 52.0 µM 6.14E-4 57 4.05E-4
16 SGTC_1324 1418-0026 3.35 34.4 µM 6.23E-4 29 4.11E-4
17 SGTC_1292 0kpi-0043 3.34 232.0 µM 6.26E-4 27 4.13E-4
18 SGTC_2850 9015429 3.31 58.4 µM 7.06E-4 31 4.69E-4
19 SGTC_1227 3909-8010 3.30 46.6 µM 7.36E-4 46 4.91E-4
20 SGTC_1327 1436-0082 3.29 2.2 µM 7.58E-4 40 5.07E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 2.14E-12 YOR046C DBP5 het Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p
0.102 3.07E-9 YML062C MFT1 hom Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
0.097 2.17E-8 YDL216C RRI1 hom Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
0.091 1.40E-7 YNL246W VPS75 hom NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress
0.090 1.86E-7 YFL017C GNA1 het Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
0.089 2.74E-7 YOR023C AHC1 hom Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
0.088 3.15E-7 YOL013C HRD1 hom Ubiquitin-protein ligase; required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon
0.085 7.37E-7 YMR055C BUB2 hom Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
0.084 1.02E-6 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin
0.080 3.52E-6 YLR433C CNA1 hom Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
0.079 4.82E-6 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.078 5.79E-6 YLR225C_p YLR225C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene
0.078 6.13E-6 YDL211C_p YDL211C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.077 8.57E-6 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.074 1.59E-5 YIR003W AIM21 hom Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton