YFL056C / AAD6

Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL056C / AAD6

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:7.86|P-value:9.13E-16 ID:SGTC_65|Compound:0798-0905|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.33|P-value:4.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.23|P-value:8.97E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.29|P-value:7.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.88|P-value:4.59E-5 ID:SGTC_484|Compound:loperamide|FD-Score:3.29|P-value:4.27E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.07|P-value:9.16E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.81|P-value:5.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:10.20|P-value:3.04E-25 ID:SGTC_709|Compound:3807-1509|FD-Score:3.38|P-value:3.01E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.09|P-value:8.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.27|P-value:4.92E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.16|P-value:7.40E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.37|P-value:3.18E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.28|P-value:4.37E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.45|P-value:1.76E-8 ID:SGTC_1747|Compound:st037496|FD-Score:-4.79|P-value:7.00E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.26|P-value:4.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.76|P-value:7.66E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.32|P-value:3.83E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.15|P-value:7.72E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.86|P-value:4.52E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.81|P-value:5.54E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.06|P-value:1.76E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.19|P-value:6.70E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.63|P-value:1.39E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.83|P-value:5.13E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.19|P-value:1.21E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:5.24E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.78|P-value:7.09E-5 ID:SGTC_3027|Compound:9089541|FD-Score:-3.15|P-value:7.52E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-4.08|P-value:2.01E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.87|P-value:4.85E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.94|P-value:3.31E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:7.86|P-value:9.13E-16 ID:SGTC_65|Compound:0798-0905|FD-Score:3.85|P-value:4.87E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-3.33|P-value:4.09E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:4.23|P-value:8.97E-6 ID:SGTC_451|Compound:chloral hydrate|FD-Score:4.29|P-value:7.08E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.88|P-value:4.59E-5 ID:SGTC_484|Compound:loperamide|FD-Score:3.29|P-value:4.27E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.07|P-value:9.16E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.81|P-value:5.66E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:10.20|P-value:3.04E-25 ID:SGTC_709|Compound:3807-1509|FD-Score:3.38|P-value:3.01E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.12|P-value:7.68E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.09|P-value:8.57E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.27|P-value:4.92E-4 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.16|P-value:7.40E-4 ID:SGTC_1706|Compound:st031321|FD-Score:3.37|P-value:3.18E-4 ID:SGTC_1707|Compound:st032323|FD-Score:3.44|P-value:2.45E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.28|P-value:4.37E-4 ID:SGTC_1745|Compound:st081495|FD-Score:5.45|P-value:1.76E-8 ID:SGTC_1747|Compound:st037496|FD-Score:-4.79|P-value:7.00E-7 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.26|P-value:4.71E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:-3.76|P-value:7.66E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.32|P-value:3.83E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.15|P-value:7.72E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.86|P-value:4.52E-5 ID:SGTC_2126|Compound:5251174|FD-Score:3.81|P-value:5.54E-5 ID:SGTC_2128|Compound:5255449|FD-Score:-5.06|P-value:1.76E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:-3.19|P-value:6.70E-4 ID:SGTC_2133|Compound:5320837|FD-Score:4.63|P-value:1.39E-6 ID:SGTC_2136|Compound:5328288|FD-Score:3.17|P-value:6.45E-4 ID:SGTC_2436|Compound:5633522|FD-Score:3.83|P-value:5.13E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.19|P-value:1.21E-5 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.06|P-value:9.70E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.23|P-value:5.24E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-3.09|P-value:9.32E-4 ID:SGTC_2941|Compound:9056145|FD-Score:3.26|P-value:4.77E-4 ID:SGTC_3011|Compound:9081274|FD-Score:-3.78|P-value:7.09E-5 ID:SGTC_3027|Compound:9089541|FD-Score:-3.15|P-value:7.52E-4 ID:SGTC_3031|Compound:9088762|FD-Score:-4.08|P-value:2.01E-5 ID:SGTC_3138|Compound:9097216|FD-Score:-3.87|P-value:4.85E-5 ID:SGTC_3309|Compound:9129340|FD-Score:3.94|P-value:3.31E-5

Top fitness defect scores for YFL056C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_669 0108-0021 10.20 26.2 µM 3.04E-25 fatty acid desaturase (OLE1) 4 9.98E-25
2 SGTC_58 0957-0393 7.86 9.0 µM 9.13E-16 cell wall 128 1.90E-15
3 SGTC_1745 st081495 5.45 74.0 µM 1.76E-8 RNA processing & uracil transport 34 2.56E-8
4 SGTC_2133 5320837 4.63 200.0 µM 1.39E-6 ERG2 17 1.85E-6
5 SGTC_451 chloral hydrate 4.29 100.0 µM 7.08E-6 39 9.09E-6
6 SGTC_431 k089-0097 4.23 107.0 µM 8.97E-6 iron homeostasis 31 1.15E-5
7 SGTC_3309 9129340 3.94 25.8 µM 3.31E-5 16 4.12E-5
8 SGTC_1878 temozolomide 3.86 1.0 mM 4.52E-5 7 5.58E-5
9 SGTC_65 0798-0905 3.85 35.0 µM 4.87E-5 calcium & mitochondrial duress 91 6.00E-5
10 SGTC_2436 5633522 3.83 8.1 µM 5.13E-5 19 6.32E-5
11 SGTC_2126 5251174 3.81 33.9 µM 5.54E-5 39 6.81E-5
12 SGTC_638 3970-0837 3.81 4.1 µM 5.66E-5 43 6.96E-5
13 SGTC_1707 st032323 3.44 6.3 µM 2.45E-4 DNA damage response 83 2.91E-4
14 SGTC_709 3807-1509 3.38 243.0 µM 3.01E-4 RSC complex & mRNA processing 29 3.56E-4
15 SGTC_1706 st031321 3.37 10.0 µM 3.18E-4 TSC3-RPN4 23 3.76E-4
16 SGTC_1803 st050068 3.32 52.4 µM 3.83E-4 NEO1-PIK1 231 4.52E-4
17 SGTC_484 loperamide 3.29 105.0 µM 4.27E-4 10 5.02E-4
18 SGTC_1713 st033146 3.28 12.8 µM 4.37E-4 53 5.14E-4
19 SGTC_1785 bathophenanthroline 3.26 24.0 µM 4.71E-4 heme requiring 88 5.53E-4
20 SGTC_2941 9056145 3.26 11.2 µM 4.77E-4 34 5.60E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 3.23E-39 YNR044W AGA1 hom Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
0.221 1.53E-38 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.206 1.62E-33 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.197 1.27E-30 YNL289W PCL1 hom Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth
0.197 1.30E-30 YJL132W_p YJL132W_p hom Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene
0.189 2.36E-28 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.187 1.07E-27 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.186 1.17E-27 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.170 4.04E-23 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.170 4.79E-23 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.168 1.37E-22 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.166 3.92E-22 YDL025C RTK1 hom Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress
0.160 1.09E-20 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.159 1.61E-20 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.151 1.30E-18 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain