YFL063W_d

Dubious open reading frame, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YFL063W / YFL063W

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:3.96|P-value:2.05E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:4.98|P-value:3.72E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:7.40|P-value:5.04E-18 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.22|P-value:4.99E-13 ID:SGTC_169|Compound:k015-0017|FD-Score:6.02|P-value:1.54E-12 ID:SGTC_378|Compound:3970-0959|FD-Score:2.75|P-value:6.59E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.07|P-value:1.13E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.79|P-value:7.53E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.18|P-value:1.53E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.79|P-value:7.41E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:3.65|P-value:1.10E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.79|P-value:5.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.95|P-value:3.81E-20 ID:SGTC_1115|Compound:galangin|FD-Score:2.75|P-value:6.57E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.10|P-value:1.50E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.46|P-value:2.74E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.70|P-value:8.09E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.69|P-value:8.49E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.89|P-value:3.08E-6 ID:SGTC_2107|Compound:5363541|FD-Score:3.67|P-value:9.95E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-2.93|P-value:4.21E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.74|P-value:6.78E-6 ID:SGTC_2121|Compound:5257820|FD-Score:2.81|P-value:5.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-2.86|P-value:5.63E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.94|P-value:7.82E-9 ID:SGTC_2333|Compound:9017922|FD-Score:3.48|P-value:2.60E-5 ID:SGTC_2487|Compound:5918373|FD-Score:2.78|P-value:5.94E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.18|P-value:1.45E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.39|P-value:3.90E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.88|P-value:7.44E-9 ID:SGTC_2919|Compound:7978188|FD-Score:2.96|P-value:2.74E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-4.13|P-value:1.17E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.33|P-value:7.31E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.42|P-value:3.33E-5 ID:SGTC_39|Compound:0986-0283|FD-Score:3.96|P-value:2.05E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:4.98|P-value:3.72E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:7.40|P-value:5.04E-18 ID:SGTC_166|Compound:k072-0058|FD-Score:-6.22|P-value:4.99E-13 ID:SGTC_169|Compound:k015-0017|FD-Score:6.02|P-value:1.54E-12 ID:SGTC_378|Compound:3970-0959|FD-Score:2.75|P-value:6.59E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:4.07|P-value:1.13E-6 ID:SGTC_664|Compound:1222-0054|FD-Score:-2.79|P-value:7.53E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.18|P-value:1.53E-9 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.79|P-value:7.41E-6 ID:SGTC_986|Compound:1493-0483|FD-Score:3.65|P-value:1.10E-5 ID:SGTC_987|Compound:1497-1013|FD-Score:2.79|P-value:5.63E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.95|P-value:3.81E-20 ID:SGTC_1115|Compound:galangin|FD-Score:2.75|P-value:6.57E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.06|P-value:1.83E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:3.10|P-value:1.50E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:3.46|P-value:2.74E-5 ID:SGTC_1913|Compound:st060213|FD-Score:2.70|P-value:8.09E-4 ID:SGTC_2102|Compound:5377816|FD-Score:2.69|P-value:8.49E-4 ID:SGTC_2103|Compound:5378138|FD-Score:3.89|P-value:3.08E-6 ID:SGTC_2107|Compound:5363541|FD-Score:3.67|P-value:9.95E-6 ID:SGTC_2112|Compound:5488546|FD-Score:-2.93|P-value:4.21E-4 ID:SGTC_2119|Compound:5528445|FD-Score:3.74|P-value:6.78E-6 ID:SGTC_2121|Compound:5257820|FD-Score:2.81|P-value:5.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-2.86|P-value:5.63E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.94|P-value:7.82E-9 ID:SGTC_2333|Compound:9017922|FD-Score:3.48|P-value:2.60E-5 ID:SGTC_2487|Compound:5918373|FD-Score:2.78|P-value:5.94E-4 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:-3.18|P-value:1.45E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.39|P-value:3.90E-5 ID:SGTC_2814|Compound:7977482|FD-Score:4.88|P-value:7.44E-9 ID:SGTC_2919|Compound:7978188|FD-Score:2.96|P-value:2.74E-4 ID:SGTC_3123|Compound:9126162|FD-Score:-4.13|P-value:1.17E-6 ID:SGTC_3134|Compound:9127454|FD-Score:-3.33|P-value:7.31E-5 ID:SGTC_3342|Compound:9147791|FD-Score:3.42|P-value:3.33E-5

Top fitness defect scores for YFL063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 7.40 7.5 µM 5.04E-18 24 6.67E-14
2 SGTC_169 k015-0017 6.02 16.0 µM 1.54E-12 2 8.99E-10
3 SGTC_41 0478-0632 4.98 82.6 µM 3.72E-9 10 3.18E-7
4 SGTC_2814 7977482 4.88 43.0 µM 7.44E-9 23 5.36E-7
5 SGTC_383 2324-0395 4.07 7.4 µM 1.13E-6 azole & statin 33 2.38E-5
6 SGTC_39 0986-0283 3.96 58.4 µM 2.05E-6 calcium & mitochondrial duress 37 3.73E-5
7 SGTC_2103 5378138 3.89 10.0 µM 3.08E-6 17 5.08E-5
8 SGTC_2119 5528445 3.74 120.6 µM 6.78E-6 26 9.22E-5
9 SGTC_2107 5363541 3.67 170.2 µM 9.95E-6 14 1.23E-4
10 SGTC_986 1493-0483 3.65 84.0 µM 1.10E-5 16 1.33E-4
11 SGTC_2333 9017922 3.48 200.0 µM 2.60E-5 41 2.55E-4
12 SGTC_1878 temozolomide 3.46 1.0 mM 2.74E-5 16 2.65E-4
13 SGTC_3342 9147791 3.42 14.5 µM 3.33E-5 34 3.08E-4
14 SGTC_2602 kawain 3.39 100.0 µM 3.90E-5 48 3.47E-4
15 SGTC_1875 nocodazole 3.10 6.0 µM 1.50E-4 tubulin folding & SWR complex 73 9.62E-4
16 SGTC_1382 3002-2117 3.06 298.0 µM 1.83E-4 40 0.00112
17 SGTC_2919 7978188 2.96 46.4 µM 2.74E-4 69 0.00152
18 SGTC_2121 5257820 2.81 149.6 µM 5.21E-4 57 0.00248
19 SGTC_987 1497-1013 2.79 404.0 µM 5.63E-4 59 0.00263
20 SGTC_2487 5918373 2.78 44.0 µM 5.94E-4 78 0.00274

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.307 3.98E-74 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.293 1.36E-67 YLR023C IZH3 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.282 1.84E-62 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.276 1.14E-59 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.261 2.89E-53 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.258 2.86E-52 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.258 4.99E-52 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.248 4.40E-48 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.239 9.40E-45 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.237 4.05E-44 YLR016C PML1 hom Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p
0.230 1.74E-41 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.230 1.90E-41 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.227 2.13E-40 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.224 3.44E-39 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.223 5.69E-39 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p