YFR009W / GCN20

Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR009W / GCN20

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.17|P-value:1.25E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:5.07|P-value:1.78E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:4.33|P-value:2.10E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.39|P-value:1.74E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:9.45|P-value:6.29E-15 ID:SGTC_51|Compound:1013-0126|FD-Score:10.40|P-value:8.54E-18 ID:SGTC_68|Compound:0986-0284|FD-Score:16.90|P-value:1.64E-43 ID:SGTC_79|Compound:0052-0007|FD-Score:4.64|P-value:7.65E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:5.07|P-value:1.77E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:8.20|P-value:1.12E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:4.24|P-value:2.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.84|P-value:8.83E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.37|P-value:1.81E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.98|P-value:5.84E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:7.66|P-value:2.02E-10 ID:SGTC_180|Compound:1486-1293|FD-Score:8.97|P-value:1.25E-13 ID:SGTC_278|Compound:4092-0821|FD-Score:5.44|P-value:4.65E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:3.86|P-value:8.14E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.10|P-value:4.09E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.52|P-value:1.14E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:5.36|P-value:6.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:5.14|P-value:1.40E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:6.15|P-value:2.69E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.89|P-value:3.38E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:7.74|P-value:1.40E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.88|P-value:3.33E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.95|P-value:6.34E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.00|P-value:2.30E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.38|P-value:1.77E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:11.10|P-value:5.65E-20 ID:SGTC_685|Compound:1278-0033|FD-Score:4.00|P-value:5.50E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.38|P-value:1.75E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.52|P-value:1.13E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:12.70|P-value:2.75E-25 ID:SGTC_764|Compound:1951-2361|FD-Score:4.77|P-value:4.98E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.40|P-value:5.31E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:7.27|P-value:1.53E-9 ID:SGTC_819|Compound:1013-0258|FD-Score:9.18|P-value:3.50E-14 ID:SGTC_823|Compound:0417-1665|FD-Score:4.78|P-value:4.88E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:6.13|P-value:2.82E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:5.91E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.83|P-value:1.00E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:6.99|P-value:5.92E-9 ID:SGTC_903|Compound:1134-0042|FD-Score:4.10|P-value:4.16E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.03|P-value:2.05E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:5.49|P-value:3.79E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:6.75|P-value:1.80E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:8.16|P-value:1.42E-11 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.68|P-value:6.79E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.89|P-value:7.36E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.95|P-value:2.60E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.68|P-value:6.87E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.37|P-value:1.83E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.94|P-value:2.85E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.63|P-value:2.19E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.83|P-value:8.96E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.81|P-value:9.45E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.81|P-value:1.09E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:-7.00|P-value:5.50E-9 ID:SGTC_1377|Compound:2944-0135|FD-Score:-5.29|P-value:7.68E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.84|P-value:8.74E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:12.10|P-value:2.41E-23 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.91|P-value:7.18E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:5.38|P-value:5.67E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:11.80|P-value:4.24E-22 ID:SGTC_1567|Compound:st069303|FD-Score:-4.16|P-value:3.35E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.65|P-value:7.57E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.64|P-value:2.15E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.89|P-value:9.71E-9 ID:SGTC_1614|Compound:st002383|FD-Score:4.77|P-value:5.00E-5 ID:SGTC_1617|Compound:st002906|FD-Score:6.52|P-value:5.16E-8 ID:SGTC_1619|Compound:st003326|FD-Score:-4.24|P-value:2.70E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.89|P-value:3.34E-5 ID:SGTC_1649|Compound:st011737|FD-Score:7.48|P-value:5.15E-10 ID:SGTC_1655|Compound:st012546|FD-Score:5.11|P-value:1.54E-5 ID:SGTC_1671|Compound:st016596|FD-Score:6.11|P-value:3.18E-7 ID:SGTC_1673|Compound:st016611|FD-Score:8.52|P-value:1.85E-12 ID:SGTC_1695|Compound:st026914|FD-Score:4.04|P-value:4.94E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.22|P-value:2.87E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.29|P-value:1.39E-9 ID:SGTC_1720|Compound:st037298|FD-Score:4.52|P-value:1.14E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.68|P-value:1.85E-10 ID:SGTC_1882|Compound:5615643|FD-Score:4.92|P-value:2.99E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.29|P-value:2.35E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.96|P-value:6.00E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.44|P-value:7.57E-8 ID:SGTC_1937|Compound:st074714|FD-Score:5.58|P-value:2.69E-6 ID:SGTC_1972|Compound:st070201|FD-Score:5.28|P-value:8.23E-6 ID:SGTC_1973|Compound:st070275|FD-Score:-5.17|P-value:1.20E-5 ID:SGTC_1999|Compound:st074831|FD-Score:6.87|P-value:1.03E-8 ID:SGTC_2038|Compound:4100038|FD-Score:4.19|P-value:3.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.42|P-value:4.97E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.06|P-value:4.68E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.83|P-value:8.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.29|P-value:2.37E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.11|P-value:4.03E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.09|P-value:1.65E-5 ID:SGTC_2231|Compound:micatex|FD-Score:4.28|P-value:2.44E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.79|P-value:9.97E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.35|P-value:6.31E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.01|P-value:5.39E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.54|P-value:4.70E-8 ID:SGTC_2316|Compound:5844804|FD-Score:4.43|P-value:1.51E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.48|P-value:1.26E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.29|P-value:2.35E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.11|P-value:3.97E-4 ID:SGTC_2384|Compound:9036245|FD-Score:5.87|P-value:8.55E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.31|P-value:7.39E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.96|P-value:6.13E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.88|P-value:3.44E-5 ID:SGTC_2437|Compound:5741531|FD-Score:4.17|P-value:3.33E-4 ID:SGTC_2445|Compound:5742597|FD-Score:7.63|P-value:2.45E-10 ID:SGTC_2472|Compound:5377652|FD-Score:4.00|P-value:5.53E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.89|P-value:3.30E-5 ID:SGTC_2488|Compound:5268135|FD-Score:6.64|P-value:3.03E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:7.33|P-value:1.14E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:14.20|P-value:1.64E-31 ID:SGTC_2616|Compound:abietic acid|FD-Score:7.94|P-value:4.68E-11 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.01|P-value:5.41E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:7.03|P-value:4.94E-9 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.62|P-value:2.29E-6 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:4.60|P-value:8.83E-5 ID:SGTC_2678|Compound:equilin|FD-Score:5.48|P-value:3.91E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.84|P-value:8.55E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.27|P-value:8.70E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.74|P-value:1.41E-6 ID:SGTC_2703|Compound:st077852|FD-Score:-4.30|P-value:2.19E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.57|P-value:4.21E-8 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.84|P-value:8.64E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.16|P-value:1.30E-5 ID:SGTC_2823|Compound:7987624|FD-Score:5.54|P-value:3.07E-6 ID:SGTC_2903|Compound:5923464|FD-Score:4.68|P-value:6.79E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-4.96|P-value:2.59E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.70|P-value:1.66E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-4.22|P-value:2.84E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.60|P-value:8.81E-5 ID:SGTC_3215|Compound:9129942|FD-Score:-4.22|P-value:2.86E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.88|P-value:7.72E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:8.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-5.96|P-value:5.57E-7 ID:SGTC_3307|Compound:9126885|FD-Score:5.43|P-value:4.76E-6 ID:SGTC_3308|Compound:9128332|FD-Score:12.10|P-value:2.39E-23 ID:SGTC_10|Compound:0279-0212|FD-Score:5.17|P-value:1.25E-5 ID:SGTC_19|Compound:0279-0214|FD-Score:5.07|P-value:1.78E-5 ID:SGTC_24|Compound:0417-1663|FD-Score:4.33|P-value:2.10E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:4.39|P-value:1.74E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:9.45|P-value:6.29E-15 ID:SGTC_51|Compound:1013-0126|FD-Score:10.40|P-value:8.54E-18 ID:SGTC_68|Compound:0986-0284|FD-Score:16.90|P-value:1.64E-43 ID:SGTC_79|Compound:0052-0007|FD-Score:4.64|P-value:7.65E-5 ID:SGTC_89|Compound:0302-0250|FD-Score:5.07|P-value:1.77E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:8.20|P-value:1.12E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:4.24|P-value:2.73E-4 ID:SGTC_124|Compound:0136-0217|FD-Score:3.84|P-value:8.83E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:4.37|P-value:1.81E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:3.98|P-value:5.84E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:7.66|P-value:2.02E-10 ID:SGTC_180|Compound:1486-1293|FD-Score:8.97|P-value:1.25E-13 ID:SGTC_278|Compound:4092-0821|FD-Score:5.44|P-value:4.65E-6 ID:SGTC_298|Compound:1391-0729|FD-Score:3.86|P-value:8.14E-4 ID:SGTC_465|Compound:cgp-37157|FD-Score:4.10|P-value:4.09E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:4.52|P-value:1.14E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:5.36|P-value:6.20E-6 ID:SGTC_523|Compound:1934-0222|FD-Score:5.14|P-value:1.40E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:6.15|P-value:2.69E-7 ID:SGTC_581|Compound:0958-0271|FD-Score:4.89|P-value:3.38E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:7.74|P-value:1.40E-10 ID:SGTC_586|Compound:0957-0265|FD-Score:-4.88|P-value:3.33E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:3.95|P-value:6.34E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:5.00|P-value:2.30E-5 ID:SGTC_668|Compound:1682-0499|FD-Score:4.38|P-value:1.77E-4 ID:SGTC_677|Compound:0929-0063|FD-Score:11.10|P-value:5.65E-20 ID:SGTC_685|Compound:1278-0033|FD-Score:4.00|P-value:5.50E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.38|P-value:1.75E-4 ID:SGTC_723|Compound:4182-0001|FD-Score:4.52|P-value:1.13E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:12.70|P-value:2.75E-25 ID:SGTC_764|Compound:1951-2361|FD-Score:4.77|P-value:4.98E-5 ID:SGTC_767|Compound:0929-0023|FD-Score:5.40|P-value:5.31E-6 ID:SGTC_768|Compound:0384-0033|FD-Score:7.27|P-value:1.53E-9 ID:SGTC_819|Compound:1013-0258|FD-Score:9.18|P-value:3.50E-14 ID:SGTC_823|Compound:0417-1665|FD-Score:4.78|P-value:4.88E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:6.13|P-value:2.82E-7 ID:SGTC_891|Compound:0929-0073|FD-Score:3.98|P-value:5.91E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:5.83|P-value:1.00E-6 ID:SGTC_901|Compound:1112-0062|FD-Score:6.99|P-value:5.92E-9 ID:SGTC_903|Compound:1134-0042|FD-Score:4.10|P-value:4.16E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:5.03|P-value:2.05E-5 ID:SGTC_981|Compound:1488-1094|FD-Score:5.49|P-value:3.79E-6 ID:SGTC_1004|Compound:4084-0029|FD-Score:6.75|P-value:1.80E-8 ID:SGTC_1005|Compound:4092-0690|FD-Score:8.16|P-value:1.42E-11 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.68|P-value:6.79E-5 ID:SGTC_1031|Compound:k035-0009|FD-Score:-3.89|P-value:7.36E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.95|P-value:2.60E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:4.68|P-value:6.87E-5 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.37|P-value:1.83E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:4.94|P-value:2.85E-5 ID:SGTC_1219|Compound:1469-0211|FD-Score:5.63|P-value:2.19E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.83|P-value:8.96E-4 ID:SGTC_1259|Compound:0671-0132|FD-Score:3.81|P-value:9.45E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:5.81|P-value:1.09E-6 ID:SGTC_1373|Compound:2887-0003|FD-Score:-7.00|P-value:5.50E-9 ID:SGTC_1377|Compound:2944-0135|FD-Score:-5.29|P-value:7.68E-6 ID:SGTC_1427|Compound:4048-4900|FD-Score:3.84|P-value:8.74E-4 ID:SGTC_1482|Compound:3346-2049|FD-Score:12.10|P-value:2.41E-23 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.91|P-value:7.18E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:5.38|P-value:5.67E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:11.80|P-value:4.24E-22 ID:SGTC_1567|Compound:st069303|FD-Score:-4.16|P-value:3.35E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.65|P-value:7.57E-5 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:5.64|P-value:2.15E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:6.89|P-value:9.71E-9 ID:SGTC_1614|Compound:st002383|FD-Score:4.77|P-value:5.00E-5 ID:SGTC_1617|Compound:st002906|FD-Score:6.52|P-value:5.16E-8 ID:SGTC_1619|Compound:st003326|FD-Score:-4.24|P-value:2.70E-4 ID:SGTC_1636|Compound:st007707|FD-Score:4.89|P-value:3.34E-5 ID:SGTC_1649|Compound:st011737|FD-Score:7.48|P-value:5.15E-10 ID:SGTC_1655|Compound:st012546|FD-Score:5.11|P-value:1.54E-5 ID:SGTC_1671|Compound:st016596|FD-Score:6.11|P-value:3.18E-7 ID:SGTC_1673|Compound:st016611|FD-Score:8.52|P-value:1.85E-12 ID:SGTC_1695|Compound:st026914|FD-Score:4.04|P-value:4.94E-4 ID:SGTC_1697|Compound:st025554|FD-Score:4.22|P-value:2.87E-4 ID:SGTC_1715|Compound:st032160|FD-Score:7.29|P-value:1.39E-9 ID:SGTC_1720|Compound:st037298|FD-Score:4.52|P-value:1.14E-4 ID:SGTC_1797|Compound:st048695|FD-Score:7.68|P-value:1.85E-10 ID:SGTC_1882|Compound:5615643|FD-Score:4.92|P-value:2.99E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.29|P-value:2.35E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.96|P-value:6.00E-4 ID:SGTC_1921|Compound:5740136|FD-Score:6.44|P-value:7.57E-8 ID:SGTC_1937|Compound:st074714|FD-Score:5.58|P-value:2.69E-6 ID:SGTC_1972|Compound:st070201|FD-Score:5.28|P-value:8.23E-6 ID:SGTC_1973|Compound:st070275|FD-Score:-5.17|P-value:1.20E-5 ID:SGTC_1999|Compound:st074831|FD-Score:6.87|P-value:1.03E-8 ID:SGTC_2038|Compound:4100038|FD-Score:4.19|P-value:3.17E-4 ID:SGTC_2056|Compound:5235370|FD-Score:5.42|P-value:4.97E-6 ID:SGTC_2063|Compound:5246145|FD-Score:4.06|P-value:4.68E-4 ID:SGTC_2082|Compound:5219693|FD-Score:3.83|P-value:8.96E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.29|P-value:2.37E-4 ID:SGTC_2146|Compound:5545642|FD-Score:4.11|P-value:4.03E-4 ID:SGTC_2148|Compound:5546263|FD-Score:5.09|P-value:1.65E-5 ID:SGTC_2231|Compound:micatex|FD-Score:4.28|P-value:2.44E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:3.79|P-value:9.97E-4 ID:SGTC_2238|Compound:6671620|FD-Score:5.35|P-value:6.31E-6 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.01|P-value:5.39E-4 ID:SGTC_2286|Compound:7945697|FD-Score:6.54|P-value:4.70E-8 ID:SGTC_2316|Compound:5844804|FD-Score:4.43|P-value:1.51E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-4.48|P-value:1.26E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.29|P-value:2.35E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.11|P-value:3.97E-4 ID:SGTC_2384|Compound:9036245|FD-Score:5.87|P-value:8.55E-7 ID:SGTC_2406|Compound:ethylparaben|FD-Score:5.31|P-value:7.39E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.96|P-value:6.13E-4 ID:SGTC_2428|Compound:5615643|FD-Score:4.88|P-value:3.44E-5 ID:SGTC_2437|Compound:5741531|FD-Score:4.17|P-value:3.33E-4 ID:SGTC_2445|Compound:5742597|FD-Score:7.63|P-value:2.45E-10 ID:SGTC_2472|Compound:5377652|FD-Score:4.00|P-value:5.53E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.89|P-value:3.30E-5 ID:SGTC_2488|Compound:5268135|FD-Score:6.64|P-value:3.03E-8 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:7.33|P-value:1.14E-9 ID:SGTC_2607|Compound:solasodine|FD-Score:14.20|P-value:1.64E-31 ID:SGTC_2616|Compound:abietic acid|FD-Score:7.94|P-value:4.68E-11 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:4.01|P-value:5.41E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:7.03|P-value:4.94E-9 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.62|P-value:2.29E-6 ID:SGTC_2672|Compound:12a-hydroxy-5-deoxydehydromunduserone|FD-Score:4.60|P-value:8.83E-5 ID:SGTC_2678|Compound:equilin|FD-Score:5.48|P-value:3.91E-6 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.84|P-value:8.55E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:5.27|P-value:8.70E-6 ID:SGTC_2699|Compound:st077704|FD-Score:5.74|P-value:1.41E-6 ID:SGTC_2703|Compound:st077852|FD-Score:-4.30|P-value:2.19E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.57|P-value:4.21E-8 ID:SGTC_2733|Compound:amorolfine|FD-Score:3.84|P-value:8.64E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:5.16|P-value:1.30E-5 ID:SGTC_2823|Compound:7987624|FD-Score:5.54|P-value:3.07E-6 ID:SGTC_2903|Compound:5923464|FD-Score:4.68|P-value:6.79E-5 ID:SGTC_3083|Compound:9117465|FD-Score:-4.96|P-value:2.59E-5 ID:SGTC_3148|Compound:9097893|FD-Score:5.70|P-value:1.66E-6 ID:SGTC_3151|Compound:9099821|FD-Score:-4.22|P-value:2.84E-4 ID:SGTC_3159|Compound:9100096|FD-Score:4.60|P-value:8.81E-5 ID:SGTC_3215|Compound:9129942|FD-Score:-4.22|P-value:2.86E-4 ID:SGTC_3218|Compound:9131285|FD-Score:-3.88|P-value:7.72E-4 ID:SGTC_3270|Compound:9137563|FD-Score:-3.83|P-value:8.83E-4 ID:SGTC_3300|Compound:9124615|FD-Score:-5.96|P-value:5.57E-7 ID:SGTC_3307|Compound:9126885|FD-Score:5.43|P-value:4.76E-6 ID:SGTC_3308|Compound:9128332|FD-Score:12.10|P-value:2.39E-23

Top fitness defect scores for YFR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_68 0986-0284 16.90 82.8 µM 1.64E-43 2 2.62E-64
2 SGTC_2607 solasodine 14.20 47.4 µM 1.64E-31 10 2.54E-46
3 SGTC_748 0136-0228 12.70 77.9 µM 2.75E-25 redox potentiating 4 5.35E-37
4 SGTC_3308 9128332 12.10 17.6 µM 2.39E-23 plasma membrane duress 17 4.27E-34
5 SGTC_1482 3346-2049 12.10 8.5 µM 2.41E-23 8 4.32E-34
6 SGTC_1510 1123-0200 11.80 71.5 µM 4.24E-22 3 3.16E-32
7 SGTC_677 0929-0063 11.10 136.0 µM 5.65E-20 1 4.77E-29
8 SGTC_51 1013-0126 10.40 23.4 µM 8.54E-18 8 8.69E-26
9 SGTC_50 0929-0078 9.45 56.4 µM 6.29E-15 10 1.68E-21
10 SGTC_819 1013-0258 9.18 27.7 µM 3.50E-14 8 2.18E-20
11 SGTC_180 1486-1293 8.97 102.8 µM 1.25E-13 12 1.46E-19
12 SGTC_1673 st016611 8.52 27.3 µM 1.85E-12 8 8.16E-18
13 SGTC_95 0471-0001 8.20 561.1 µM 1.12E-11 2 1.21E-16
14 SGTC_1005 4092-0690 8.16 4.4 µM 1.42E-11 plasma membrane duress 7 1.71E-16
15 SGTC_2616 abietic acid 7.94 100.0 µM 4.68E-11 6 1.01E-15
16 SGTC_583 1488-1091 7.74 88.9 µM 1.40E-10 2 5.16E-15
17 SGTC_1797 st048695 7.68 56.8 µM 1.85E-10 NEO1 21 7.85E-15
18 SGTC_176 1486-1328 7.66 72.8 µM 2.02E-10 14 8.94E-15
19 SGTC_2445 5742597 7.63 35.6 µM 2.45E-10 7 1.20E-14
20 SGTC_1649 st011737 7.48 51.3 µM 5.15E-10 12 3.61E-14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.554 1.75E-268 YKR026C GCN3 hom Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
0.547 1.00E-260 YDR283C GCN2 hom Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control
0.489 2.55E-201 YDR007W TRP1 hom Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
0.487 6.85E-199 YEL009C GCN4 hom Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
0.479 8.00E-191 YDR008C_d YDR008C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.476 3.85E-189 YGL026C TRP5 hom Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis
0.449 5.54E-165 YDR354W TRP4 hom Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
0.428 5.24E-149 YGL117W_p YGL117W_p hom Putative protein of unknown function
0.427 9.61E-149 YDR035W ARO3 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan
0.402 4.85E-130 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.388 1.91E-120 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
0.344 4.54E-93 YER090W TRP2 hom Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
0.262 1.49E-53 YGL148W ARO2 hom Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
0.154 3.49E-19 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.153 4.17E-19 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole