YFR012W / DCV1

Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR012W / DCV1

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:3.21|P-value:2.16E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.12|P-value:2.71E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.46|P-value:6.75E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.02|P-value:4.71E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.25|P-value:1.66E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.38|P-value:1.06E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.28|P-value:1.47E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.10|P-value:3.41E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.02|P-value:4.60E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.83|P-value:1.35E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.11|P-value:3.31E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.63|P-value:3.07E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.97|P-value:5.69E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.73|P-value:2.12E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.27|P-value:1.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:5.87E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.01|P-value:4.37E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.04|P-value:4.30E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.97|P-value:6.67E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.59|P-value:4.19E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.84|P-value:9.14E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:10.30|P-value:3.69E-30 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-11.20|P-value:2.06E-35 ID:SGTC_2596|Compound:sinensetin|FD-Score:-6.23|P-value:3.26E-12 ID:SGTC_2601|Compound:securinine|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.87|P-value:1.11E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.09|P-value:3.24E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.94|P-value:6.33E-4 ID:SGTC_2907|Compound:7721985|FD-Score:7.05|P-value:4.71E-15 ID:SGTC_2982|Compound:9019404|FD-Score:-3.95|P-value:6.55E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-2.90|P-value:6.90E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.84|P-value:1.24E-5 ID:SGTC_3049|Compound:9092223|FD-Score:2.96|P-value:5.92E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.22|P-value:1.59E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.19|P-value:2.39E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.99|P-value:2.08E-8 ID:SGTC_3281|Compound:9140613|FD-Score:3.81|P-value:1.44E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.21|P-value:2.16E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.12|P-value:2.71E-6 ID:SGTC_181|Compound:1447-1644|FD-Score:3.05|P-value:4.21E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.46|P-value:6.75E-5 ID:SGTC_325|Compound:2810-4341|FD-Score:3.02|P-value:4.71E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.25|P-value:1.66E-4 ID:SGTC_409|Compound:arachidonic acid|FD-Score:3.38|P-value:1.06E-4 ID:SGTC_1039|Compound:k821-0043|FD-Score:2.98|P-value:5.48E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.28|P-value:1.47E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.27|P-value:1.68E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.10|P-value:3.41E-4 ID:SGTC_1633|Compound:st005664|FD-Score:3.02|P-value:4.60E-4 ID:SGTC_1666|Compound:st014829|FD-Score:3.83|P-value:1.35E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.11|P-value:3.31E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:-3.63|P-value:3.07E-5 ID:SGTC_1912|Compound:st060209|FD-Score:2.97|P-value:5.69E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.73|P-value:2.12E-5 ID:SGTC_1915|Compound:st067105|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.27|P-value:1.64E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.51|P-value:5.87E-5 ID:SGTC_2397|Compound:5161689|FD-Score:-3.01|P-value:4.37E-4 ID:SGTC_2416|Compound:tofa|FD-Score:3.04|P-value:4.30E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.97|P-value:6.67E-6 ID:SGTC_2516|Compound:gossypol|FD-Score:3.59|P-value:4.19E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:2.84|P-value:9.14E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:10.30|P-value:3.69E-30 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-11.20|P-value:2.06E-35 ID:SGTC_2596|Compound:sinensetin|FD-Score:-6.23|P-value:3.26E-12 ID:SGTC_2601|Compound:securinine|FD-Score:-3.25|P-value:1.65E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.87|P-value:1.11E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.01|P-value:4.40E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.09|P-value:3.24E-4 ID:SGTC_2800|Compound:7887935|FD-Score:2.94|P-value:6.33E-4 ID:SGTC_2907|Compound:7721985|FD-Score:7.05|P-value:4.71E-15 ID:SGTC_2982|Compound:9019404|FD-Score:-3.95|P-value:6.55E-6 ID:SGTC_2985|Compound:9022375|FD-Score:-2.90|P-value:6.90E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.84|P-value:1.24E-5 ID:SGTC_3049|Compound:9092223|FD-Score:2.96|P-value:5.92E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.22|P-value:1.59E-6 ID:SGTC_3202|Compound:9113761|FD-Score:-2.88|P-value:7.45E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.19|P-value:2.39E-4 ID:SGTC_3266|Compound:9136860|FD-Score:4.99|P-value:2.08E-8 ID:SGTC_3281|Compound:9140613|FD-Score:3.81|P-value:1.44E-5

Top fitness defect scores for YFR012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2593 nobiletin 10.30 86.2 µM 3.69E-30 3 2.69E-25
2 SGTC_2907 7721985 7.05 69.9 µM 4.71E-15 1 8.86E-13
3 SGTC_3266 9136860 4.99 49.5 µM 2.08E-8 cell wall 29 2.95E-7
4 SGTC_2429 5902844 3.97 64.4 µM 6.67E-6 25 3.62E-5
5 SGTC_2602 kawain 3.87 100.0 µM 1.11E-5 31 5.55E-5
6 SGTC_3045 9092950 3.84 49.5 µM 1.24E-5 17 6.06E-5
7 SGTC_1666 st014829 3.83 29.0 µM 1.35E-5 calcium & mitochondrial duress 29 6.51E-5
8 SGTC_3281 9140613 3.81 49.5 µM 1.44E-5 RPP1 & pyrimidine depletion 25 6.90E-5
9 SGTC_1913 st060213 3.73 96.1 µM 2.12E-5 37 9.52E-5
10 SGTC_2516 gossypol 3.59 71.5 µM 4.19E-5 22 1.68E-4
11 SGTC_2105 5350118 3.51 200.0 µM 5.87E-5 41 2.23E-4
12 SGTC_409 arachidonic acid 3.38 100.0 µM 1.06E-4 30 3.65E-4
13 SGTC_1232 0279-0259 3.29 161.0 µM 1.53E-4 50 4.97E-4
14 SGTC_2049 5262831 3.27 67.2 µM 1.64E-4 61 5.28E-4
15 SGTC_1350 1495-0454 3.27 146.0 µM 1.68E-4 58 5.38E-4
16 SGTC_172 1112-0046 3.21 2.6 µM 2.16E-4 NEO1 64 6.65E-4
17 SGTC_3263 9137018 3.19 49.5 µM 2.39E-4 49 7.22E-4
18 SGTC_1713 st033146 3.11 12.8 µM 3.31E-4 64 9.50E-4
19 SGTC_1631 benzylvanillin 3.10 81.9 µM 3.41E-4 Golgi 68 9.74E-4
20 SGTC_181 1447-1644 3.05 8.1 µM 4.21E-4 endomembrane recycling 71 0.00116

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.238 1.59E-44 YGL110C CUE3 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
0.215 1.43E-36 YGR030C POP6 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.207 5.62E-34 YCR004C YCP4 hom Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.160 9.01E-21 YMR196W_p YMR196W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
0.126 2.64E-13 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.124 5.32E-13 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.106 7.21E-10 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.102 3.11E-9 YOR376W_d YOR376W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
0.100 6.85E-9 YDR460W TFB3 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit
0.096 2.73E-8 YNR057C BIO4 hom Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels
0.093 5.86E-8 YJR147W HMS2 hom Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication
0.093 6.54E-8 YDR063W AIM7 hom Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss
0.091 1.42E-7 YOR244W ESA1 het Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy
0.084 9.74E-7 YHR086W-A_p YHR086W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.084 1.08E-6 YIR036C_p IRC24_p hom Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci