YFR017C / IGD1

Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR017C / IGD1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-3.84|P-value:3.03E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.20|P-value:5.36E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.40|P-value:2.55E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.06|P-value:6.82E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.37|P-value:2.86E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.78|P-value:4.86E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:5.21|P-value:4.44E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-4.53|P-value:1.19E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.33|P-value:3.13E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.57|P-value:3.38E-9 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.55|P-value:1.08E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.62|P-value:7.92E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.15|P-value:4.93E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.67|P-value:8.71E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.81|P-value:2.78E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.30|P-value:2.76E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-5.40|P-value:9.58E-9 ID:SGTC_1594|Compound:piperine|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.44|P-value:1.86E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.05|P-value:7.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.29|P-value:2.89E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.87|P-value:2.89E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.32|P-value:3.46E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.95|P-value:9.95E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.75|P-value:6.22E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.03|P-value:1.86E-5 ID:SGTC_2439|Compound:5492030|FD-Score:-3.14|P-value:5.19E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.27|P-value:4.23E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.40|P-value:2.59E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.48|P-value:1.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.09|P-value:8.10E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-3.84|P-value:3.03E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:3.20|P-value:5.36E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.40|P-value:2.55E-4 ID:SGTC_727|Compound:3032-0951|FD-Score:-3.06|P-value:6.82E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:-3.39|P-value:1.98E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.37|P-value:2.86E-4 ID:SGTC_943|Compound:3253-1379|FD-Score:4.78|P-value:4.86E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:5.21|P-value:4.44E-8 ID:SGTC_946|Compound:3434-1334|FD-Score:-4.53|P-value:1.19E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:-4.33|P-value:3.13E-6 ID:SGTC_950|Compound:1165-0508|FD-Score:3.77|P-value:5.81E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:-5.57|P-value:3.38E-9 ID:SGTC_977|Compound:1348-1378|FD-Score:-4.55|P-value:1.08E-6 ID:SGTC_983|Compound:1491-0821|FD-Score:3.42|P-value:2.34E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-3.62|P-value:7.92E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:-3.15|P-value:4.93E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.67|P-value:8.71E-5 ID:SGTC_1413|Compound:3910-0535|FD-Score:3.14|P-value:6.83E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.81|P-value:2.78E-7 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.30|P-value:2.76E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-5.40|P-value:9.58E-9 ID:SGTC_1594|Compound:piperine|FD-Score:3.07|P-value:8.77E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.07|P-value:8.61E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.44|P-value:1.86E-6 ID:SGTC_1633|Compound:st005664|FD-Score:-3.05|P-value:7.18E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.29|P-value:2.89E-4 ID:SGTC_1683|Compound:st010134|FD-Score:4.87|P-value:2.89E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.32|P-value:3.46E-4 ID:SGTC_1867|Compound:st057372|FD-Score:-2.95|P-value:9.95E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.50|P-value:1.74E-4 ID:SGTC_2049|Compound:5262831|FD-Score:3.75|P-value:6.22E-5 ID:SGTC_2343|Compound:7990716|FD-Score:4.03|P-value:1.86E-5 ID:SGTC_2439|Compound:5492030|FD-Score:-3.14|P-value:5.19E-4 ID:SGTC_2484|Compound:5809818|FD-Score:3.20|P-value:5.38E-4 ID:SGTC_2490|Compound:carminic acid|FD-Score:3.27|P-value:4.23E-4 ID:SGTC_2492|Compound:derrusnin|FD-Score:3.86|P-value:3.84E-5 ID:SGTC_2503|Compound:beta-caryophyllene alcohol|FD-Score:3.34|P-value:3.19E-4 ID:SGTC_2621|Compound:lithochol-11-enic acid|FD-Score:3.40|P-value:2.59E-4 ID:SGTC_2691|Compound:st077356|FD-Score:3.41|P-value:2.50E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.48|P-value:1.88E-4 ID:SGTC_2930|Compound:9013230|FD-Score:3.21|P-value:5.23E-4 ID:SGTC_3085|Compound:9117376|FD-Score:3.09|P-value:8.10E-4

Top fitness defect scores for YFR017C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_944 3370-0224 5.21 231.0 µM 4.44E-8 7 9.28E-8
2 SGTC_1683 st010134 4.87 710.0 nM 2.89E-7 11 5.44E-7
3 SGTC_943 3253-1379 4.78 105.0 µM 4.86E-7 12 8.89E-7
4 SGTC_2343 7990716 4.03 14.8 µM 1.86E-5 16 2.79E-5
5 SGTC_2492 derrusnin 3.86 100.0 µM 3.84E-5 5 5.57E-5
6 SGTC_950 1165-0508 3.77 94.1 µM 5.81E-5 33 8.25E-5
7 SGTC_2049 5262831 3.75 67.2 µM 6.22E-5 34 8.80E-5
8 SGTC_1347 1493-0251 3.67 600.0 nM 8.71E-5 mitochondrial response to ROS 20 1.21E-4
9 SGTC_1975 st070967 3.50 30.8 µM 1.74E-4 48 2.34E-4
10 SGTC_2722 naftopidil 3.48 47.2 µM 1.88E-4 14 2.52E-4
11 SGTC_983 1491-0821 3.42 12.2 µM 2.34E-4 26 3.09E-4
12 SGTC_2691 st077356 3.41 60.2 µM 2.50E-4 54 3.29E-4
13 SGTC_555 4296-0685 3.40 37.0 µM 2.55E-4 ergosterol biosynthesis 24 3.35E-4
14 SGTC_2621 lithochol-11-enic acid 3.40 100.0 µM 2.59E-4 49 3.41E-4
15 SGTC_850 0388-0143 3.37 75.9 µM 2.86E-4 27 3.74E-4
16 SGTC_2503 beta-caryophyllene alcohol 3.34 24.7 µM 3.19E-4 23 4.15E-4
17 SGTC_1727 st034309 3.32 9.9 µM 3.46E-4 74 4.48E-4
18 SGTC_2490 carminic acid 3.27 95.4 µM 4.23E-4 15 5.42E-4
19 SGTC_2930 9013230 3.21 14.9 µM 5.23E-4 heme biosynthesis & mitochondrial translocase 75 6.63E-4
20 SGTC_427 1354-0053 3.20 47.3 µM 5.36E-4 53 6.79E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.80E-29 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.175 1.48E-24 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.170 3.67E-23 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.170 4.13E-23 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.169 7.87E-23 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.169 1.30E-22 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.161 7.19E-21 YKL130C SHE2 hom RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud
0.161 1.05E-20 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.152 9.45E-19 YKR102W FLO10 hom Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth
0.149 4.71E-18 YLR179C YLR179C hom Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus
0.147 1.09E-17 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.147 1.31E-17 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.146 2.18E-17 YIL042C PKP1 hom Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p
0.141 2.15E-16 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.139 6.76E-16 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress