HIPHOP chemogenomics database

YFR019W / FAB1

1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR019W / FAB1

Click on Significant Values for Screen Details

Top fitness defect scores for YFR019W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2533	agelasine	11.80	13.7 µM	1.53E-30	ERG2	3	1.09E-32
2	SGTC_1844	rapamycin	9.42	4.0 nM	5.63E-20		43	2.33E-21
3	SGTC_70	0141-0289	8.42	43.3 µM	2.48E-16	mitochondrial stress	35	1.88E-17
4	SGTC_275	trichlorophene	7.93	5.7 µM	1.09E-14	mitochondrial stress	77	1.08E-15
5	SGTC_2250	alverine citrate	7.36	130.0 µM	6.90E-13		29	9.32E-14
6	SGTC_58	0957-0393	7.01	9.0 µM	7.50E-12	cell wall	163	1.20E-12
7	SGTC_236	1509-0011	6.55	5.3 µM	1.42E-10		273	2.83E-11
8	SGTC_119	0121-0043	6.05	24.8 µM	2.90E-9	mitochondrial stress	28	7.18E-10
9	SGTC_310	1273-0058	6.02	1.1 µM	3.53E-9	mitochondrial stress	144	8.87E-10
10	SGTC_520	3584-0023	5.55	682.0 µM	4.76E-8		4	1.45E-8
11	SGTC_2679	rapamycin	5.46	1.0 nM	7.69E-8		89	2.42E-8
12	SGTC_63	0099-0242	5.40	26.7 µM	1.04E-7	mitochondrial stress	40	3.36E-8
13	SGTC_173	1273-0061	4.99	2.7 µM	7.98E-7	mitochondrial stress	149	2.99E-7
14	SGTC_467	ro 31-8220	4.94	72.8 µM	1.00E-6	calcium & mitochondrial duress	51	3.81E-7
15	SGTC_10	0279-0212	4.88	42.6 µM	1.36E-6	TRP & mitochondrial translation	68	5.27E-7
16	SGTC_2834	9001755	4.75	58.4 µM	2.54E-6		20	1.03E-6
17	SGTC_1742	st038235	4.56	28.9 µM	6.00E-6	mitochondrial stress	95	2.60E-6
18	SGTC_2349	9023730	4.21	187.1 µM	2.62E-5		17	1.27E-5
19	SGTC_596	1155-0152	4.15	116.0 µM	3.40E-5	TRP & mitochondrial translation	32	1.67E-5
20	SGTC_2682	pyrogallin	4.14	40.0 µM	3.53E-5	copper-dependent oxidative stress	23	1.74E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.382	3.31E-117	YER028C	MIG3	hom	Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.373	5.78E-111	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.361	1.91E-103	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.360	5.06E-103	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.353	1.31E-98	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.353	8.88E-99	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.352	2.69E-98	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.352	2.86E-98	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.347	1.57E-95	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.343	2.82E-93	YGL064C	MRH4	hom	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
0.343	3.04E-93	YMR072W	ABF2	hom	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.338	2.23E-90	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.337	1.46E-89	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.334	2.37E-88	YKR085C	MRPL20	hom	Mitochondrial ribosomal protein of the large subunit
0.333	1.29E-87	YDL045W-A	MRP10	hom	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs