YFR022W / ROG3

Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins; ROG3 has a paralog, ROD1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR022W / ROG3

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:2.95|P-value:6.69E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.77|P-value:2.11E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:2.29E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:4.10|P-value:4.34E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:2.88|P-value:8.49E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:2.84|P-value:9.89E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.19|P-value:2.64E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.17|P-value:3.61E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.28|P-value:1.84E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.07|P-value:4.11E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.73|P-value:2.52E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.93|P-value:8.85E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.61|P-value:5.70E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.19|P-value:2.56E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.42|P-value:1.31E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.11|P-value:3.62E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.15|P-value:2.99E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.07|P-value:5.00E-6 ID:SGTC_1843|Compound:st055809|FD-Score:3.09|P-value:3.84E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.90|P-value:7.87E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.92|P-value:7.28E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.19|P-value:2.59E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.57|P-value:5.24E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.06|P-value:5.37E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.69|P-value:3.96E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-3.31|P-value:2.01E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.94|P-value:9.57E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.43|P-value:1.05E-6 ID:SGTC_2411|Compound:st077133|FD-Score:-3.16|P-value:3.70E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.43|P-value:9.62E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:1.94E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.45|P-value:8.73E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.09|P-value:3.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.99|P-value:7.13E-4 ID:SGTC_3116|Compound:9124943|FD-Score:2.94|P-value:6.73E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.11|P-value:4.16E-6 ID:SGTC_3218|Compound:9131285|FD-Score:4.24|P-value:2.06E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.46|P-value:8.48E-5 ID:SGTC_87|Compound:0100-0052|FD-Score:2.95|P-value:6.69E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.77|P-value:2.11E-5 ID:SGTC_145|Compound:3737-0113|FD-Score:4.22|P-value:2.29E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:4.10|P-value:4.34E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:2.88|P-value:8.49E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:2.84|P-value:9.89E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:3.19|P-value:2.64E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:-3.17|P-value:3.61E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.28|P-value:1.84E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.07|P-value:4.11E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.73|P-value:2.52E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:-2.93|P-value:8.85E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:-3.61|P-value:5.70E-5 ID:SGTC_969|Compound:1313-0238|FD-Score:3.19|P-value:2.56E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.42|P-value:1.31E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.11|P-value:3.62E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.15|P-value:2.99E-4 ID:SGTC_1736|Compound:st036774|FD-Score:4.07|P-value:5.00E-6 ID:SGTC_1843|Compound:st055809|FD-Score:3.09|P-value:3.84E-4 ID:SGTC_1851|Compound:st056236|FD-Score:2.90|P-value:7.87E-4 ID:SGTC_1860|Compound:st056228|FD-Score:2.92|P-value:7.28E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.19|P-value:2.59E-4 ID:SGTC_1876|Compound:myriocin|FD-Score:3.57|P-value:5.24E-5 ID:SGTC_1909|Compound:st060837|FD-Score:3.29|P-value:1.71E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.06|P-value:5.37E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.69|P-value:3.96E-5 ID:SGTC_2306|Compound:7482397|FD-Score:-3.31|P-value:2.01E-4 ID:SGTC_2327|Compound:6189656|FD-Score:3.94|P-value:9.57E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.43|P-value:1.05E-6 ID:SGTC_2411|Compound:st077133|FD-Score:-3.16|P-value:3.70E-4 ID:SGTC_2440|Compound:5628896|FD-Score:-3.48|P-value:1.01E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.17|P-value:2.76E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.43|P-value:9.62E-5 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.26|P-value:1.94E-4 ID:SGTC_2713|Compound:st079149|FD-Score:3.45|P-value:8.73E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.25|P-value:2.01E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.09|P-value:3.93E-4 ID:SGTC_2868|Compound:9035608|FD-Score:-2.99|P-value:7.13E-4 ID:SGTC_3116|Compound:9124943|FD-Score:2.94|P-value:6.73E-4 ID:SGTC_3210|Compound:9128157|FD-Score:4.11|P-value:4.16E-6 ID:SGTC_3218|Compound:9131285|FD-Score:4.24|P-value:2.06E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.46|P-value:8.48E-5

Top fitness defect scores for YFR022W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3218 9131285 4.24 49.5 µM 2.06E-6 endomembrane recycling 32 1.11E-5
2 SGTC_145 3737-0113 4.22 38.4 µM 2.29E-6 DNA intercalators 65 1.21E-5
3 SGTC_3210 9128157 4.11 49.5 µM 4.16E-6 44 2.02E-5
4 SGTC_323 4013-0906 4.10 34.3 µM 4.34E-6 ERG2 11 2.10E-5
5 SGTC_1736 st036774 4.07 51.0 µM 5.00E-6 28 2.37E-5
6 SGTC_2327 6189656 3.94 200.0 µM 9.57E-6 25 4.14E-5
7 SGTC_128 0906-2981 3.77 13.4 µM 2.11E-5 19 8.18E-5
8 SGTC_946 3434-1334 3.73 87.4 µM 2.52E-5 35 9.53E-5
9 SGTC_1876 myriocin 3.57 605.0 nM 5.24E-5 45 1.79E-4
10 SGTC_3306 9127676 3.46 59.8 µM 8.48E-5 40 2.71E-4
11 SGTC_2713 st079149 3.45 53.4 µM 8.73E-5 38 2.78E-4
12 SGTC_2453 5731132 3.43 22.2 µM 9.62E-5 36 3.02E-4
13 SGTC_1909 st060837 3.29 51.5 µM 1.71E-4 79 4.96E-4
14 SGTC_626 0214-0009 3.28 33.0 µM 1.84E-4 copper-dependent oxidative stress 43 5.28E-4
15 SGTC_2588 indole-3-carbinol 3.26 100.0 µM 1.94E-4 83 5.52E-4
16 SGTC_2716 st080858 3.25 38.6 µM 2.01E-4 60S ribosome export 39 5.70E-4
17 SGTC_969 1313-0238 3.19 134.0 µM 2.56E-4 mitochondrial processes 54 7.03E-4
18 SGTC_1869 3',7'-dimethoxyflavone 3.19 40.3 µM 2.59E-4 55 7.10E-4
19 SGTC_515 4092-1064 3.19 102.0 µM 2.64E-4 plasma membrane duress 89 7.21E-4
20 SGTC_2444 5485484 3.17 36.4 µM 2.76E-4 70 7.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.53E-21 YGR212W SLI1 hom N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin
0.109 2.51E-10 YMR296C LCB1 het Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
0.107 4.47E-10 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.105 1.01E-9 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.101 4.57E-9 YNL151C RPC31 het RNA polymerase III subunit C31
0.097 1.76E-8 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.097 1.95E-8 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.097 2.13E-8 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.097 2.14E-8 YKL044W_p YKL044W_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.096 2.91E-8 YER063W THO1 hom Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
0.093 7.44E-8 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.092 9.67E-8 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.092 1.01E-7 YCR020C PET18 hom Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin
0.092 1.08E-7 YDL079C MRK1 hom Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
0.088 3.14E-7 YLR316C TAD3 het Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs