YFR032C-B_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR032C-B / YFR032C-B

Click on Significant Values for Screen Details ID:SGTC_51|Compound:1013-0126|FD-Score:-3.11|P-value:4.80E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.90|P-value:9.42E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.23|P-value:2.71E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.49|P-value:2.20E-9 ID:SGTC_505|Compound:gw-5074|FD-Score:3.56|P-value:6.96E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.12|P-value:5.26E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-2.94|P-value:9.21E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:2.95|P-value:7.90E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.58|P-value:6.28E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.59|P-value:4.63E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.96|P-value:7.74E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.09|P-value:6.00E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.95|P-value:7.86E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.24|P-value:2.59E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_1920|Compound:st075728|FD-Score:4.36|P-value:1.54E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-4.17|P-value:4.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.41|P-value:1.29E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.64|P-value:4.94E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.38|P-value:1.39E-6 ID:SGTC_2181|Compound:6316240|FD-Score:4.79|P-value:1.52E-7 ID:SGTC_2334|Compound:9017922|FD-Score:-3.01|P-value:7.07E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-2.96|P-value:8.64E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.10|P-value:4.58E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.65|P-value:4.77E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.15|P-value:4.26E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.28|P-value:9.74E-12 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.86|P-value:1.87E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.08|P-value:5.46E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:2.99E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.42|P-value:1.28E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_2802|Compound:7925815|FD-Score:9.87|P-value:3.02E-26 ID:SGTC_2803|Compound:7707263|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.06|P-value:5.33E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.53|P-value:7.88E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.88|P-value:1.67E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.11|P-value:4.80E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:2.90|P-value:9.42E-4 ID:SGTC_408|Compound:cantharidin|FD-Score:3.23|P-value:2.71E-4 ID:SGTC_424|Compound:splitomicin|FD-Score:5.49|P-value:2.20E-9 ID:SGTC_505|Compound:gw-5074|FD-Score:3.56|P-value:6.96E-5 ID:SGTC_579|Compound:4491-1009|FD-Score:4.12|P-value:5.26E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-2.94|P-value:9.21E-4 ID:SGTC_861|Compound:0443-0273|FD-Score:2.95|P-value:7.90E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.58|P-value:6.28E-5 ID:SGTC_1015|Compound:4130-4525|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_1070|Compound:indatraline|FD-Score:4.59|P-value:4.63E-7 ID:SGTC_1098|Compound:clofazimine|FD-Score:2.96|P-value:7.74E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.09|P-value:6.00E-6 ID:SGTC_1260|Compound:0700-1617|FD-Score:2.95|P-value:7.86E-4 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:-3.21|P-value:3.38E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.24|P-value:2.59E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.92|P-value:1.37E-5 ID:SGTC_1920|Compound:st075728|FD-Score:4.36|P-value:1.54E-6 ID:SGTC_1941|Compound:st076221|FD-Score:-4.17|P-value:4.67E-6 ID:SGTC_2075|Compound:5212009|FD-Score:3.41|P-value:1.29E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:3.45|P-value:1.10E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.64|P-value:4.94E-5 ID:SGTC_2167|Compound:5876490|FD-Score:4.38|P-value:1.39E-6 ID:SGTC_2181|Compound:6316240|FD-Score:4.79|P-value:1.52E-7 ID:SGTC_2334|Compound:9017922|FD-Score:-3.01|P-value:7.07E-4 ID:SGTC_2339|Compound:9000433|FD-Score:-2.96|P-value:8.64E-4 ID:SGTC_2358|Compound:9037157|FD-Score:3.10|P-value:4.58E-4 ID:SGTC_2397|Compound:5161689|FD-Score:3.65|P-value:4.77E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.15|P-value:4.26E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:6.28|P-value:9.74E-12 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:3.86|P-value:1.87E-5 ID:SGTC_2682|Compound:pyrogallin|FD-Score:-3.08|P-value:5.46E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.21|P-value:2.99E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.42|P-value:1.28E-4 ID:SGTC_2799|Compound:7812892|FD-Score:3.13|P-value:3.98E-4 ID:SGTC_2802|Compound:7925815|FD-Score:9.87|P-value:3.02E-26 ID:SGTC_2803|Compound:7707263|FD-Score:3.38|P-value:1.50E-4 ID:SGTC_2843|Compound:9000894|FD-Score:3.06|P-value:5.33E-4 ID:SGTC_2845|Compound:9003024|FD-Score:3.53|P-value:7.88E-5 ID:SGTC_3153|Compound:9100258|FD-Score:2.97|P-value:7.43E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.88|P-value:1.67E-5

Top fitness defect scores for YFR032C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2802 7925815 9.87 54.5 µM 3.02E-26 1 2.76E-23
2 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 6.28 92.6 µM 9.74E-12 4 1.66E-10
3 SGTC_424 splitomicin 5.49 100.0 mM 2.20E-9 4 1.98E-8
4 SGTC_2181 6316240 4.79 54.3 µM 1.52E-7 11 8.25E-7
5 SGTC_1070 indatraline 4.59 8.8 µM 4.63E-7 60S ribosome export 14 2.21E-6
6 SGTC_2167 5876490 4.38 200.0 µM 1.39E-6 22 5.84E-6
7 SGTC_1920 st075728 4.36 45.7 µM 1.54E-6 13 6.40E-6
8 SGTC_579 4491-1009 4.12 110.0 µM 5.26E-6 60S ribosome export 19 1.89E-5
9 SGTC_1238 0333-0287 4.09 48.8 µM 6.00E-6 Golgi 24 2.12E-5
10 SGTC_1860 st056228 3.92 74.6 µM 1.37E-5 21 4.39E-5
11 SGTC_3193 9111931 3.88 49.5 µM 1.67E-5 28 5.23E-5
12 SGTC_2634 4'-methoxyflavone 3.86 100.0 µM 1.87E-5 38 5.78E-5
13 SGTC_2397 5161689 3.65 200.0 µM 4.77E-5 46 1.32E-4
14 SGTC_2166 5933061 3.64 31.5 µM 4.94E-5 tubulin folding & SWR complex 52 1.36E-4
15 SGTC_911 3456-4043 3.58 236.0 µM 6.28E-5 mitochondrial processes 38 1.69E-4
16 SGTC_505 gw-5074 3.56 63.9 µM 6.96E-5 72 1.85E-4
17 SGTC_2845 9003024 3.53 43.0 µM 7.88E-5 amide catabolism 60 2.06E-4
18 SGTC_2131 toluylene red 3.45 5.3 µM 1.10E-4 60S ribosome export 41 2.77E-4
19 SGTC_2707 st078556 3.42 66.6 µM 1.28E-4 22 3.17E-4
20 SGTC_2075 5212009 3.41 200.0 µM 1.29E-4 21 3.20E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.63E-16 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.124 5.84E-13 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.121 2.17E-12 YIR029W DAL2 hom Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
0.121 2.32E-12 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.117 9.81E-12 YNL182C IPI3 het Component of the Rix1 complex (Rix1p-Ipi1p-Ipi3p) and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene
0.115 2.28E-11 YDR178W SDH4 hom Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.111 1.35E-10 YLR264C-A_p YLR264C-A_p hom Putative protein of unknown function
0.109 2.52E-10 YLR119W SRN2 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus
0.108 4.11E-10 YMR242W-A_p YMR242W-A_p hom Putative protein of unknown function
0.107 5.10E-10 YML049C RSE1 het Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport
0.106 7.60E-10 YKL117W SBA1 hom Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress
0.105 1.14E-9 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.102 3.16E-9 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
0.098 1.48E-8 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.096 2.25E-8 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization