HIPHOP chemogenomics database

YFR039C_p

Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces

Zygosity: Homozygous strain

fixedexpanded
Profile for YFR039C / YFR039C

Click on Significant Values for Screen Details

Top fitness defect scores for YFR039C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2602	kawain	5.98	100.0 µM	3.86E-11		3	1.11E-9
2	SGTC_2596	sinensetin	5.64	100.0 µM	4.28E-10		5	8.63E-9
3	SGTC_2806	7952793	3.98	58.4 µM	7.10E-6		21	3.41E-5
4	SGTC_153	4077-0274	3.55	519.7 µM	5.34E-5		26	1.91E-4
5	SGTC_994	3910-0338	3.50	138.0 µM	6.67E-5	calcium & mitochondrial duress	65	2.31E-4
6	SGTC_1006	4099-6547	3.44	255.0 µM	8.66E-5		41	2.88E-4
7	SGTC_1333	1482-0047	3.26	286.0 µM	1.87E-4		38	5.57E-4
8	SGTC_2415	st077333	3.19	57.7 µM	2.47E-4		97	7.08E-4
9	SGTC_861	0443-0273	3.18	110.0 µM	2.64E-4		36	7.47E-4
10	SGTC_534	k292-0788	3.10	63.4 µM	3.59E-4	mitochondrial processes	60	9.72E-4
11	SGTC_2816	7982706	3.08	58.4 µM	3.84E-4	azole & statin	95	0.00103
12	SGTC_1330	1469-0054	3.00	61.8 µM	5.22E-4	iron homeostasis	54	0.00134
13	SGTC_2640	pentamidine	2.99	10.4 µM	5.53E-4	mitochondrial processes	74	0.00141
14	SGTC_2568	diosmetin	2.98	100.0 µM	5.74E-4		71	0.00145
15	SGTC_152	4469-0003	2.95	551.2 µM	6.42E-4		57	0.00160
16	SGTC_479	n-linoleoylglycine	2.95	10.0 µM	6.46E-4		40	0.00161
17	SGTC_1563	conessine	2.94	56.1 µM	6.52E-4		61	0.00162
18	SGTC_1337	1486-1011	2.84	40.3 µM	9.48E-4		67	0.00223
19	SGTC_883	0850-0245	2.81	24.6 µM	0.00107	cell wall	86	0.00248
20	SGTC_2305	7443522	2.79	69.2 µM	0.00115		69	0.00264

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.209	2.18E-34	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.194	1.16E-29	YKL171W	NNK1	hom	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.193	1.88E-29	YBR262C	AIM5	hom	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.183	1.40E-26	YML074C	FPR3	hom	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.167	1.81E-22	YBL015W	ACH1	hom	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.163	2.78E-21	YBL036C	YBL036C	hom	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.153	4.98E-19	YCL023C_d	YCL023C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.149	3.26E-18	YJR098C_p	YJR098C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.144	5.83E-17	YMR017W	SPO20	hom	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.139	6.91E-16	YDR382W	RPP2B	hom	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.135	4.90E-15	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.133	1.26E-14	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.131	2.94E-14	YKL131W_d	YKL131W_d	hom	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130	4.13E-14	YOR082C_d	YOR082C_d	hom	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.125	3.44E-13	YFL063W_d	YFL063W_d	hom	Dubious open reading frame, based on available experimental and comparative sequence data