YFR039C_p

Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces

Zygosity: Homozygous strain
fixedexpanded
Profile for YFR039C / YFR039C

Click on Significant Values for Screen Details ID:SGTC_152|Compound:4469-0003|FD-Score:2.95|P-value:6.42E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.55|P-value:5.34E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.49|P-value:8.60E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:2.95|P-value:6.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.10|P-value:3.59E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.00|P-value:8.07E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.67|P-value:2.43E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.48|P-value:8.93E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.18|P-value:2.64E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:6.67E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.44|P-value:8.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.79|P-value:1.21E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.23|P-value:2.54E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.05|P-value:5.09E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.00|P-value:5.22E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.26|P-value:1.87E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.84|P-value:9.48E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.94|P-value:6.52E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.97|P-value:7.05E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-2.91|P-value:8.88E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.81|P-value:2.02E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.99|P-value:6.52E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.30|P-value:1.93E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.00|P-value:6.16E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:2.47E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-2.89|P-value:9.37E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.98|P-value:5.74E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.72|P-value:3.14E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.89|P-value:1.39E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.64|P-value:4.28E-10 ID:SGTC_2602|Compound:kawain|FD-Score:5.98|P-value:3.86E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.04|P-value:5.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.99|P-value:5.53E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.69|P-value:3.57E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.30|P-value:1.94E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.11|P-value:4.08E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:6.00E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.98|P-value:7.10E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.08|P-value:3.84E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-2.94|P-value:7.77E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.34|P-value:1.42E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.92|P-value:1.21E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.23|P-value:2.60E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-2.89|P-value:9.62E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.28|P-value:2.11E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.05|P-value:5.17E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.95|P-value:6.42E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:3.55|P-value:5.34E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.49|P-value:8.60E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_479|Compound:n-linoleoylglycine|FD-Score:2.95|P-value:6.46E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:3.10|P-value:3.59E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:-4.00|P-value:8.07E-6 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.67|P-value:2.43E-7 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.48|P-value:8.93E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.18|P-value:2.64E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.50|P-value:6.67E-5 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.44|P-value:8.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.79|P-value:1.21E-7 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.23|P-value:2.54E-6 ID:SGTC_1327|Compound:1436-0082|FD-Score:-3.05|P-value:5.09E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:3.00|P-value:5.22E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.26|P-value:1.87E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.84|P-value:9.48E-4 ID:SGTC_1563|Compound:conessine|FD-Score:2.94|P-value:6.52E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-2.97|P-value:7.05E-4 ID:SGTC_1696|Compound:st025591|FD-Score:-2.91|P-value:8.88E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.81|P-value:2.02E-5 ID:SGTC_1947|Compound:st076332|FD-Score:-2.99|P-value:6.52E-4 ID:SGTC_2019|Compound:4016004|FD-Score:-3.30|P-value:1.93E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.00|P-value:6.16E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-3.12|P-value:4.00E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.19|P-value:2.47E-4 ID:SGTC_2430|Compound:5571206|FD-Score:-2.89|P-value:9.37E-4 ID:SGTC_2459|Compound:5811157|FD-Score:-2.88|P-value:9.92E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.98|P-value:5.74E-4 ID:SGTC_2570|Compound:licareol|FD-Score:-3.72|P-value:3.14E-5 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.89|P-value:1.39E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:5.64|P-value:4.28E-10 ID:SGTC_2602|Compound:kawain|FD-Score:5.98|P-value:3.86E-11 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:-3.04|P-value:5.45E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:2.99|P-value:5.53E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.69|P-value:3.57E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:-3.30|P-value:1.94E-4 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:-3.11|P-value:4.08E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:-3.57|P-value:6.00E-5 ID:SGTC_2806|Compound:7952793|FD-Score:3.98|P-value:7.10E-6 ID:SGTC_2816|Compound:7982706|FD-Score:3.08|P-value:3.84E-4 ID:SGTC_2882|Compound:9058044|FD-Score:-2.94|P-value:7.77E-4 ID:SGTC_2887|Compound:9044784|FD-Score:-4.34|P-value:1.42E-6 ID:SGTC_2888|Compound:9058547|FD-Score:-3.92|P-value:1.21E-5 ID:SGTC_3216|Compound:9129716|FD-Score:-4.23|P-value:2.60E-6 ID:SGTC_3263|Compound:9137018|FD-Score:-2.89|P-value:9.62E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.28|P-value:2.11E-4 ID:SGTC_3285|Compound:9112818|FD-Score:-3.05|P-value:5.17E-4

Top fitness defect scores for YFR039C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2602 kawain 5.98 100.0 µM 3.86E-11 3 1.11E-9
2 SGTC_2596 sinensetin 5.64 100.0 µM 4.28E-10 5 8.63E-9
3 SGTC_2806 7952793 3.98 58.4 µM 7.10E-6 21 3.41E-5
4 SGTC_153 4077-0274 3.55 519.7 µM 5.34E-5 26 1.91E-4
5 SGTC_994 3910-0338 3.50 138.0 µM 6.67E-5 calcium & mitochondrial duress 65 2.31E-4
6 SGTC_1006 4099-6547 3.44 255.0 µM 8.66E-5 41 2.88E-4
7 SGTC_1333 1482-0047 3.26 286.0 µM 1.87E-4 38 5.57E-4
8 SGTC_2415 st077333 3.19 57.7 µM 2.47E-4 97 7.08E-4
9 SGTC_861 0443-0273 3.18 110.0 µM 2.64E-4 36 7.47E-4
10 SGTC_534 k292-0788 3.10 63.4 µM 3.59E-4 mitochondrial processes 60 9.72E-4
11 SGTC_2816 7982706 3.08 58.4 µM 3.84E-4 azole & statin 95 0.00103
12 SGTC_1330 1469-0054 3.00 61.8 µM 5.22E-4 iron homeostasis 54 0.00134
13 SGTC_2640 pentamidine 2.99 10.4 µM 5.53E-4 mitochondrial processes 74 0.00141
14 SGTC_2568 diosmetin 2.98 100.0 µM 5.74E-4 71 0.00145
15 SGTC_152 4469-0003 2.95 551.2 µM 6.42E-4 57 0.00160
16 SGTC_479 n-linoleoylglycine 2.95 10.0 µM 6.46E-4 40 0.00161
17 SGTC_1563 conessine 2.94 56.1 µM 6.52E-4 61 0.00162
18 SGTC_1337 1486-1011 2.84 40.3 µM 9.48E-4 67 0.00223
19 SGTC_883 0850-0245 2.81 24.6 µM 0.00107 cell wall 86 0.00248
20 SGTC_2305 7443522 2.79 69.2 µM 0.00115 69 0.00264

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.209 2.18E-34 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.194 1.16E-29 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.193 1.88E-29 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.183 1.40E-26 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.167 1.81E-22 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.163 2.78E-21 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.153 4.98E-19 YCL023C_d YCL023C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
0.149 3.26E-18 YJR098C_p YJR098C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.144 5.83E-17 YMR017W SPO20 hom Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
0.139 6.91E-16 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.135 4.90E-15 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.133 1.26E-14 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.131 2.94E-14 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.130 4.13E-14 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.125 3.44E-13 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data