HIPHOP chemogenomics database
YFR046C / CNN1 
Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YFR046C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.121 | 2.18E-12 | YDR374C_p | YDR374C_p | hom | Putative protein of unknown function |
| 0.095 | 3.54E-8 | YFR017C | IGD1 | hom | Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication |
| 0.092 | 9.68E-8 | YOL152W | FRE7 | hom | Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels |
| 0.089 | 2.62E-7 | YOL055C | THI20 | hom | Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p |
| 0.088 | 3.01E-7 | YMR023C | MSS1 | hom | Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 |
| 0.085 | 7.99E-7 | YBR050C | REG2 | hom | Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease |
| 0.083 | 1.66E-6 | YNR024W | MPP6 | hom | Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes |
| 0.082 | 2.16E-6 | YFR053C | HXK1 | hom | Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication |
| 0.081 | 2.74E-6 | YDR116C | MRPL1 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.079 | 4.43E-6 | YIR013C | GAT4 | hom | Protein containing GATA family zinc finger motifs |
| 0.079 | 4.56E-6 | YPR182W | SMX3 | het | Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F |
| 0.077 | 7.13E-6 | YKL096W-A | CWP2 | hom | Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
| 0.076 | 9.50E-6 | YPR176C | BET2 | het | Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
| 0.075 | 1.27E-5 | YDR021W | FAL1 | het | Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases |
| 0.074 | 1.62E-5 | YHR209W | CRG1 | hom | S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin |