YGL002W / ERP6

Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL002W / ERP6

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:5.82|P-value:2.79E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:3.89|P-value:5.40E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.51|P-value:1.57E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.20|P-value:7.39E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.44|P-value:4.59E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.65|P-value:1.75E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.51|P-value:2.41E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.60|P-value:2.19E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.54|P-value:2.88E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.06|P-value:8.23E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.21|P-value:4.89E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.79|P-value:8.14E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.32|P-value:4.82E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.31|P-value:5.04E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.44|P-value:3.12E-4 ID:SGTC_1986|Compound:st071812|FD-Score:4.15|P-value:1.79E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.34|P-value:4.53E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.57|P-value:1.91E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.45|P-value:4.53E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.33|P-value:4.66E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.78|P-value:8.41E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:5.82|P-value:2.79E-9 ID:SGTC_17|Compound:0960-0276|FD-Score:3.89|P-value:5.40E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.51|P-value:1.57E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.20|P-value:7.39E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.44|P-value:4.59E-6 ID:SGTC_125|Compound:0133-0007|FD-Score:3.51|P-value:2.43E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.04|P-value:2.81E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:4.65|P-value:1.75E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:3.51|P-value:2.41E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.29|P-value:5.32E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:4.60|P-value:2.19E-6 ID:SGTC_636|Compound:0kpi-0074|FD-Score:3.72|P-value:1.05E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:4.54|P-value:2.88E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-3.06|P-value:8.23E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-3.21|P-value:4.89E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:3.79|P-value:8.14E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.32|P-value:4.82E-4 ID:SGTC_1651|Compound:st011928|FD-Score:3.31|P-value:5.04E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.44|P-value:3.12E-4 ID:SGTC_1986|Compound:st071812|FD-Score:4.15|P-value:1.79E-5 ID:SGTC_2098|Compound:5376439|FD-Score:3.34|P-value:4.53E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.57|P-value:1.91E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.22|P-value:6.89E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:4.45|P-value:4.53E-6 ID:SGTC_2769|Compound:toremifene|FD-Score:3.32|P-value:4.84E-4 ID:SGTC_3172|Compound:9105863|FD-Score:3.33|P-value:4.66E-4 ID:SGTC_3285|Compound:9112818|FD-Score:3.78|P-value:8.41E-5

Top fitness defect scores for YGL002W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_9 0092-0002 5.82 10.4 µM 2.79E-9 6 2.89E-9
2 SGTC_131 0141-0277 4.65 33.9 µM 1.75E-6 22 1.69E-6
3 SGTC_145 3737-0113 4.60 38.4 µM 2.19E-6 DNA intercalators 55 2.12E-6
4 SGTC_647 0140-0236 4.54 81.0 µM 2.88E-6 7 2.78E-6
5 SGTC_2762 leflunomide 4.45 42.1 µM 4.53E-6 16 4.35E-6
6 SGTC_115 0527-0192 4.44 112.0 µM 4.59E-6 52 4.40E-6
7 SGTC_1986 st071812 4.15 45.0 µM 1.79E-5 3 1.70E-5
8 SGTC_126 0417-1624 4.04 672.5 µM 2.81E-5 DNA intercalators 29 2.66E-5
9 SGTC_17 0960-0276 3.89 49.8 µM 5.40E-5 35 5.09E-5
10 SGTC_1046 2001-0062 3.79 216.0 µM 8.14E-5 22 7.64E-5
11 SGTC_3285 9112818 3.78 20.9 µM 8.41E-5 cell wall 37 7.90E-5
12 SGTC_636 0kpi-0074 3.72 126.0 µM 1.05E-4 26 9.83E-5
13 SGTC_2105 5350118 3.57 200.0 µM 1.91E-4 37 1.79E-4
14 SGTC_143 4032-1194 3.51 15.7 µM 2.41E-4 88 2.25E-4
15 SGTC_125 0133-0007 3.51 11.8 µM 2.43E-4 DNA intercalators 19 2.27E-4
16 SGTC_1926 methyl fluorone black 3.44 53.6 µM 3.12E-4 DNA intercalators 81 2.90E-4
17 SGTC_2098 5376439 3.34 882.5 nM 4.53E-4 28 4.21E-4
18 SGTC_3172 9105863 3.33 49.5 µM 4.66E-4 ERG2 10 4.33E-4
19 SGTC_1452 4194-0072 3.32 190.0 µM 4.82E-4 32 4.48E-4
20 SGTC_2769 toremifene 3.32 3.7 µM 4.84E-4 43 4.50E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.341 4.66E-92 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.319 4.12E-80 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.282 1.69E-62 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.243 2.75E-46 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.239 1.38E-44 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.223 6.25E-39 YBL008W-A_p YBL008W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.221 1.74E-38 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.219 1.33E-37 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.212 2.77E-35 YML047W-A_d YML047W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.211 6.39E-35 YMR030W RSF1 hom Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes
0.197 8.67E-31 YPL197C_d YPL197C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
0.197 1.02E-30 YKR079C TRZ1 het tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
0.194 1.26E-29 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.193 1.70E-29 YDR155C CPR1 hom Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress
0.188 6.76E-28 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data