YGL017W / ATE1

Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL017W / ATE1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:4.58|P-value:2.13E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:3.26|P-value:1.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.02|P-value:4.17E-4 ID:SGTC_393|Compound:acivicin|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.25|P-value:1.31E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-2.97|P-value:5.13E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.97|P-value:5.62E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-2.94|P-value:5.59E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.91|P-value:6.49E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.18|P-value:2.17E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.11|P-value:2.99E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.72|P-value:1.90E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.92|P-value:1.01E-18 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.77|P-value:6.41E-8 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.22|P-value:1.83E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.95|P-value:5.40E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.89|P-value:6.99E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.90|P-value:6.68E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.05|P-value:3.74E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.89|P-value:6.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.77|P-value:1.56E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.26|P-value:1.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.57|P-value:3.94E-5 ID:SGTC_1984|Compound:st072354|FD-Score:2.92|P-value:6.33E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.88|P-value:7.33E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.55|P-value:4.29E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.40|P-value:8.72E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.85|P-value:4.24E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.34|P-value:1.80E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.78|P-value:1.49E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.81|P-value:9.70E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.87|P-value:7.58E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.81|P-value:9.38E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.17|P-value:1.97E-6 ID:SGTC_2808|Compound:7946468|FD-Score:-3.17|P-value:2.22E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.60|P-value:3.49E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.44|P-value:7.19E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.99|P-value:4.76E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:4.58|P-value:2.13E-7 ID:SGTC_99|Compound:0109-0120|FD-Score:3.26|P-value:1.61E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:3.02|P-value:4.17E-4 ID:SGTC_393|Compound:acivicin|FD-Score:2.82|P-value:9.12E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.25|P-value:1.31E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-2.97|P-value:5.13E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.83|P-value:8.87E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:-3.01|P-value:4.26E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:-3.97|P-value:5.62E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:-2.94|P-value:5.59E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-2.91|P-value:6.49E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.18|P-value:2.17E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:3.11|P-value:2.99E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:-3.72|P-value:1.90E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-7.92|P-value:1.01E-18 ID:SGTC_1120|Compound:ficusin|FD-Score:-4.77|P-value:6.41E-8 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.22|P-value:1.83E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.95|P-value:5.40E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:2.89|P-value:6.99E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-2.90|P-value:6.68E-4 ID:SGTC_1563|Compound:conessine|FD-Score:4.05|P-value:3.74E-6 ID:SGTC_1569|Compound:carminic acid|FD-Score:2.89|P-value:6.91E-4 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.77|P-value:1.56E-5 ID:SGTC_1903|Compound:st060211|FD-Score:3.26|P-value:1.58E-4 ID:SGTC_1938|Compound:st074717|FD-Score:3.31|P-value:1.26E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.57|P-value:3.94E-5 ID:SGTC_1984|Compound:st072354|FD-Score:2.92|P-value:6.33E-4 ID:SGTC_2121|Compound:5257820|FD-Score:2.88|P-value:7.33E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-3.55|P-value:4.29E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.40|P-value:8.72E-5 ID:SGTC_2386|Compound:9075165|FD-Score:4.85|P-value:4.24E-8 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:5.34|P-value:1.80E-9 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.78|P-value:1.49E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:2.81|P-value:9.70E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:2.87|P-value:7.58E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.20|P-value:2.06E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.00|P-value:4.61E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:2.81|P-value:9.38E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:3.10|P-value:3.03E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-4.17|P-value:1.97E-6 ID:SGTC_2808|Compound:7946468|FD-Score:-3.17|P-value:2.22E-4 ID:SGTC_2839|Compound:9003951|FD-Score:3.60|P-value:3.49E-5 ID:SGTC_2876|Compound:9059903|FD-Score:3.44|P-value:7.19E-5 ID:SGTC_3338|Compound:9144300|FD-Score:-2.99|P-value:4.76E-4

Top fitness defect scores for YGL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 5.34 3.7 µM 1.80E-9 22 4.68E-8
2 SGTC_2386 9075165 4.85 157.4 µM 4.24E-8 3 6.29E-7
3 SGTC_6 0844-0013 4.58 19.8 µM 2.13E-7 52 2.38E-6
4 SGTC_445 e6 berbamine 4.25 66.0 µM 1.31E-6 NEO1-PIK1 93 1.07E-5
5 SGTC_1563 conessine 4.05 56.1 µM 3.74E-6 13 2.52E-5
6 SGTC_2514 salinomycin 3.78 42.7 µM 1.49E-5 52 7.92E-5
7 SGTC_1572 epiandrosterone 3.77 68.9 µM 1.56E-5 33 8.20E-5
8 SGTC_2839 9003951 3.60 26.0 µM 3.49E-5 17 1.60E-4
9 SGTC_2876 9059903 3.44 26.0 µM 7.19E-5 25 2.91E-4
10 SGTC_2338 7999974 3.40 200.0 µM 8.72E-5 44 3.41E-4
11 SGTC_1938 st074717 3.31 56.4 µM 1.26E-4 25 4.64E-4
12 SGTC_1903 st060211 3.26 78.3 µM 1.58E-4 54 5.57E-4
13 SGTC_99 0109-0120 3.26 622.8 µM 1.61E-4 35 5.67E-4
14 SGTC_2640 pentamidine 3.20 10.4 µM 2.06E-4 mitochondrial processes 60 6.95E-4
15 SGTC_1059 3448-6867 3.18 171.0 µM 2.17E-4 33 7.27E-4
16 SGTC_1093 fluphenazine 3.11 8.0 µM 2.99E-4 45 9.48E-4
17 SGTC_2763 lisinopril 3.10 49.3 µM 3.03E-4 31 9.56E-4
18 SGTC_376 3970-0862 3.02 59.1 µM 4.17E-4 58 0.00125
19 SGTC_2693 st077581 3.00 40.7 µM 4.61E-4 91 0.00136
20 SGTC_1984 st072354 2.92 53.1 µM 6.33E-4 50 0.00176

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.278 9.00E-61 YER067C-A_d YER067C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.269 1.46E-56 YDR068W DOS2 hom Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.241 9.38E-46 YMR173W DDR48 hom DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress
0.234 4.06E-43 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.232 4.11E-42 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.230 1.91E-41 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.222 8.60E-39 YLR288C MEC3 hom DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
0.222 1.15E-38 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.213 9.37E-36 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.211 4.72E-35 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.210 7.32E-35 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.207 6.79E-34 YDL049C KNH1 hom Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
0.204 6.46E-33 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.204 9.79E-33 YNL242W ATG2 hom Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; forms cytoplasmic foci upon DNA replication stress
0.202 2.40E-32 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1