YGL023C / PIB2

Protein of unknown function; contains FYVE domain; similar to Fab1 and Vps27

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL023C / PIB2

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-6.32|P-value:2.58E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:-7.47|P-value:1.11E-13 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.00|P-value:4.09E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:4.21E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.89|P-value:6.31E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.62|P-value:2.24E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.84|P-value:9.67E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.26|P-value:1.77E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.37|P-value:1.09E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:4.37|P-value:1.11E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.26|P-value:7.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.67|P-value:1.85E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:4.15|P-value:2.80E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.51|P-value:2.68E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.86|P-value:9.02E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.77|P-value:1.28E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.50|P-value:3.54E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.90|P-value:7.61E-5 ID:SGTC_1634|Compound:st006576|FD-Score:-5.71|P-value:9.87E-9 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.37|P-value:4.36E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-5.70|P-value:1.03E-8 ID:SGTC_2014|Compound:4013930|FD-Score:3.90|P-value:7.77E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.29|P-value:5.89E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.84|P-value:7.53E-5 ID:SGTC_2277|Compound:7947813|FD-Score:-3.59|P-value:1.96E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.33|P-value:6.33E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.22|P-value:9.00E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.50|P-value:3.47E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.09|P-value:3.66E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.68|P-value:2.00E-6 ID:SGTC_2797|Compound:7859098|FD-Score:4.00|P-value:5.15E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-4.07|P-value:3.00E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.65|P-value:3.14E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.91|P-value:7.41E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-3.86|P-value:7.12E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.29|P-value:7.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.55|P-value:4.86E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-6.32|P-value:2.58E-10 ID:SGTC_142|Compound:0335-0849|FD-Score:-7.47|P-value:1.11E-13 ID:SGTC_237|Compound:nikkomycin|FD-Score:-4.00|P-value:4.09E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.38|P-value:4.21E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.89|P-value:6.31E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.32|P-value:6.55E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.62|P-value:2.24E-4 ID:SGTC_470|Compound:aa-861|FD-Score:3.84|P-value:9.67E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.26|P-value:1.77E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_512|Compound:prima-1|FD-Score:4.37|P-value:1.09E-5 ID:SGTC_633|Compound:0437-0093|FD-Score:4.37|P-value:1.11E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:3.26|P-value:7.88E-4 ID:SGTC_720|Compound:r052-1644|FD-Score:3.67|P-value:1.85E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:4.35|P-value:1.19E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:4.15|P-value:2.80E-5 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.51|P-value:2.68E-4 ID:SGTC_803|Compound:4488-1585|FD-Score:3.86|P-value:9.02E-5 ID:SGTC_858|Compound:0438-0351|FD-Score:3.77|P-value:1.28E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:-3.71|P-value:1.28E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.50|P-value:3.54E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.90|P-value:7.61E-5 ID:SGTC_1634|Compound:st006576|FD-Score:-5.71|P-value:9.87E-9 ID:SGTC_1874|Compound:staurosporine|FD-Score:-3.37|P-value:4.36E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-5.70|P-value:1.03E-8 ID:SGTC_2014|Compound:4013930|FD-Score:3.90|P-value:7.77E-5 ID:SGTC_2015|Compound:5119600|FD-Score:-3.29|P-value:5.89E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_2205|Compound:7238770|FD-Score:-3.84|P-value:7.53E-5 ID:SGTC_2277|Compound:7947813|FD-Score:-3.59|P-value:1.96E-4 ID:SGTC_2315|Compound:7733312|FD-Score:3.33|P-value:6.33E-4 ID:SGTC_2357|Compound:9067248|FD-Score:3.22|P-value:9.00E-4 ID:SGTC_2467|Compound:5474540|FD-Score:3.50|P-value:3.47E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.57|P-value:2.70E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.09|P-value:3.66E-5 ID:SGTC_2666|Compound:tannic acid|FD-Score:-4.68|P-value:2.00E-6 ID:SGTC_2797|Compound:7859098|FD-Score:4.00|P-value:5.15E-5 ID:SGTC_2805|Compound:7950783|FD-Score:-4.07|P-value:3.00E-5 ID:SGTC_2851|Compound:9015922|FD-Score:4.65|P-value:3.14E-6 ID:SGTC_2853|Compound:9015042|FD-Score:3.91|P-value:7.41E-5 ID:SGTC_2911|Compound:7942208|FD-Score:-3.86|P-value:7.12E-5 ID:SGTC_3068|Compound:9116768|FD-Score:3.29|P-value:7.24E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.55|P-value:4.86E-6

Top fitness defect scores for YGL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2851 9015922 4.65 71.4 µM 3.14E-6 22 1.66E-6
2 SGTC_3089 9117425 4.55 49.5 µM 4.86E-6 11 2.62E-6
3 SGTC_512 prima-1 4.37 270.0 µM 1.09E-5 DNA intercalators 18 6.11E-6
4 SGTC_633 0437-0093 4.37 97.7 µM 1.11E-5 DNA intercalators 7 6.26E-6
5 SGTC_722 3534-0461 4.35 190.0 µM 1.19E-5 PDR1 26 6.72E-6
6 SGTC_511 blebbistatin 4.35 171.0 µM 1.19E-5 DNA intercalators 13 6.72E-6
7 SGTC_471 1-acyl-paf 4.26 4.0 µM 1.77E-5 DNA intercalators 26 1.02E-5
8 SGTC_784 4579-0127 4.15 173.0 µM 2.80E-5 16 1.65E-5
9 SGTC_2603 homopterocarpin 4.09 100.0 µM 3.66E-5 32 2.19E-5
10 SGTC_2797 7859098 4.00 81.8 µM 5.15E-5 28 3.13E-5
11 SGTC_2853 9015042 3.91 58.4 µM 7.41E-5 27 4.59E-5
12 SGTC_1520 flindersine 3.90 88.0 µM 7.61E-5 33 4.72E-5
13 SGTC_2014 4013930 3.90 200.0 µM 7.77E-5 33 4.82E-5
14 SGTC_803 4488-1585 3.86 147.0 µM 9.02E-5 12 5.64E-5
15 SGTC_470 aa-861 3.84 153.0 µM 9.67E-5 sphingolipid biosynthesis & PDR1 57 6.07E-5
16 SGTC_858 0438-0351 3.77 2.8 µM 1.28E-4 copper-dependent oxidative stress 25 8.14E-5
17 SGTC_720 r052-1644 3.67 49.9 µM 1.85E-4 TSC3-RPN4 34 1.20E-4
18 SGTC_468 gf-109203x 3.62 121.0 µM 2.24E-4 amide catabolism 7 1.47E-4
19 SGTC_2595 hexamethylquercetagetin 3.57 100.0 µM 2.70E-4 37 1.78E-4
20 SGTC_2467 5474540 3.50 200.0 µM 3.47E-4 29 2.33E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 5.71E-34 YMR119W ASI1 hom Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; ASI1 has a paralog, ASI3, that arose from the whole genome duplication
0.202 3.12E-32 YDR458C HEH2 hom Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle
0.187 1.11E-27 YDR060W MAK21 het Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
0.186 1.44E-27 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.173 6.80E-24 YNL317W PFS2 het Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex
0.165 5.83E-22 YMR208W ERG12 het Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
0.160 1.59E-20 YER003C PMI40 het Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
0.159 1.69E-20 YHR159W_p TDA11_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele
0.150 2.06E-18 YGR156W PTI1 het Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
0.141 2.20E-16 YKL139W CTK1 hom Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13
0.122 1.38E-12 YDL058W USO1 het Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex
0.119 4.15E-12 YBR170C NPL4 hom Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP)
0.096 2.59E-8 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.092 9.48E-8 YDR362C TFC6 het One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110
0.091 1.43E-7 YER099C PRS2 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication