HIPHOP chemogenomics database

YGL027C / CWH41

Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL027C / CWH41

Click on Significant Values for Screen Details

Top fitness defect scores for YGL027C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_351	caspofungin	16.30	25.0 nM	3.64E-50	cell wall	2	3.28E-60
2	SGTC_2582	agaric acid	13.40	100.0 µM	1.20E-34	redox potentiating	25	1.78E-41
3	SGTC_22	0964-0034	7.93	14.5 µM	2.77E-13	unfolded protein response	10	1.07E-15
4	SGTC_3078	9116413	7.05	49.5 µM	7.27E-11	unfolded protein response	6	8.78E-13
5	SGTC_951	1171-0579	6.66	82.7 µM	7.29E-10	cell wall	26	1.41E-11
6	SGTC_2289	7946404	5.48	165.1 µM	3.21E-7		45	2.14E-8
7	SGTC_2007	4011539	4.95	71.8 µM	3.40E-6	cell wall signaling	35	3.65E-7
8	SGTC_121	0557-0495	4.47	61.3 µM	2.45E-5	calcium & mitochondrial duress	43	3.92E-6
9	SGTC_3212	9128307	4.46	49.5 µM	2.58E-5		30	4.15E-6
10	SGTC_2399	5884133	4.44	200.0 µM	2.73E-5	cell wall signaling	53	4.44E-6
11	SGTC_2023	5144124	4.38	124.0 µM	3.45E-5		19	5.90E-6
12	SGTC_147	4466-0538	4.20	29.2 µM	6.88E-5	ergosterol biosynthesis	10	1.35E-5
13	SGTC_1623	st003709	4.17	20.3 µM	7.56E-5	calcium & mitochondrial duress	61	1.51E-5
14	SGTC_531	3788-1495	4.13	174.0 µM	8.72E-5	unfolded protein response	16	1.79E-5
15	SGTC_149	3970-0822	4.11	46.1 µM	9.53E-5	tubulin folding & SWR complex	91	1.99E-5
16	SGTC_1033	k072-0102	4.10	21.3 µM	9.71E-5	60S ribosome export	18	2.04E-5
17	SGTC_2124	5246320	4.10	200.0 µM	9.78E-5	heme biosynthesis & mitochondrial translocase	17	2.05E-5
18	SGTC_999	4022-0066	4.05	22.7 µM	1.19E-4	Golgi	40	2.60E-5
19	SGTC_2016	5121758	3.91	140.0 µM	1.95E-4	redox potentiating	56	4.70E-5
20	SGTC_255	tunicamycin	3.73	200.5 nM	3.48E-4	unfolded protein response	85	9.40E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.299	3.18E-70	YBR229C	ROT2	hom	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.256	3.11E-51	YNL027W	CRZ1	hom	Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.235	2.50E-43	YNL106C	INP52	hom	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.217	3.43E-37	YGR196C	FYV8	hom	Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.214	5.81E-36	YML052W	SUR7	hom	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.209	1.69E-34	YOR049C	RSB1	hom	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.205	2.69E-33	YBR260C	RGD1	hom	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.201	7.58E-32	YEL036C	ANP1	hom	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
0.200	1.19E-31	YPL232W	SSO1	hom	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.196	1.67E-30	YNL074C	MLF3	hom	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
0.191	6.06E-29	YOL003C	PFA4	hom	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.188	3.88E-28	YMR109W	MYO5	hom	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.184	4.38E-27	YOR050C_d	YOR050C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.182	1.94E-26	YLR331C_d	JIP3_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.179	1.38E-25	YHR204W	MNL1	hom	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation