YGL041C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL041C / YGL041C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.85|P-value:2.21E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.08|P-value:7.73E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:6.93E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.92|P-value:1.56E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_264|Compound:promethazine|FD-Score:8.03|P-value:1.47E-14 ID:SGTC_301|Compound:4119-0100|FD-Score:4.30|P-value:2.34E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:4.06|P-value:5.99E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.55|P-value:3.88E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.51|P-value:4.35E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.37|P-value:7.15E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.20|P-value:2.22E-9 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.56|P-value:3.74E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.38|P-value:6.88E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.35|P-value:7.70E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.31|P-value:8.78E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.50|P-value:4.60E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.31|P-value:2.27E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.19|P-value:3.64E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.95|P-value:9.35E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.35|P-value:7.49E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.40|P-value:6.27E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.01|P-value:7.30E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.62|P-value:3.03E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.67|P-value:2.58E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.06|P-value:6.13E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:7.88E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.59|P-value:3.36E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.73|P-value:3.70E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.23|P-value:3.14E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.44|P-value:1.34E-5 ID:SGTC_1986|Compound:st071812|FD-Score:5.95|P-value:8.71E-9 ID:SGTC_1994|Compound:st072947|FD-Score:4.16|P-value:4.12E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.48|P-value:5.01E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.90|P-value:1.08E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.10|P-value:5.28E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.23|P-value:3.11E-5 ID:SGTC_3040|Compound:9091894|FD-Score:4.23|P-value:3.12E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.75|P-value:1.92E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.30|P-value:9.03E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.57|P-value:3.66E-4 ID:SGTC_3310|Compound:9130229|FD-Score:5.63|P-value:4.99E-8 ID:SGTC_9|Compound:0092-0002|FD-Score:4.85|P-value:2.21E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:5.08|P-value:7.73E-7 ID:SGTC_187|Compound:1488-2104|FD-Score:3.38|P-value:6.93E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.92|P-value:1.56E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.87|P-value:1.24E-4 ID:SGTC_264|Compound:promethazine|FD-Score:8.03|P-value:1.47E-14 ID:SGTC_301|Compound:4119-0100|FD-Score:4.30|P-value:2.34E-5 ID:SGTC_302|Compound:1094-0063|FD-Score:4.06|P-value:5.99E-5 ID:SGTC_343|Compound:4130-2827|FD-Score:3.55|P-value:3.88E-4 ID:SGTC_378|Compound:3970-0959|FD-Score:-3.51|P-value:4.35E-4 ID:SGTC_380|Compound:3970-0968|FD-Score:3.37|P-value:7.15E-4 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:6.20|P-value:2.22E-9 ID:SGTC_634|Compound:1611-4317|FD-Score:-3.56|P-value:3.74E-4 ID:SGTC_663|Compound:1486-0733|FD-Score:3.38|P-value:6.88E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:3.35|P-value:7.70E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.31|P-value:8.78E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.50|P-value:4.60E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.31|P-value:2.27E-5 ID:SGTC_1316|Compound:1272-0050|FD-Score:4.19|P-value:3.64E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.95|P-value:9.35E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.35|P-value:7.49E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:-3.40|P-value:6.27E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:3.51|P-value:4.50E-4 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:4.01|P-value:7.30E-5 ID:SGTC_1519|Compound:esterone|FD-Score:3.62|P-value:3.03E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:3.67|P-value:2.58E-4 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:4.06|P-value:6.13E-5 ID:SGTC_1862|Compound:st057513|FD-Score:3.99|P-value:7.88E-5 ID:SGTC_1897|Compound:st060201|FD-Score:3.59|P-value:3.36E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:4.73|P-value:3.70E-6 ID:SGTC_1979|Compound:st071809|FD-Score:3.79|P-value:1.67E-4 ID:SGTC_1984|Compound:st072354|FD-Score:4.23|P-value:3.14E-5 ID:SGTC_1985|Compound:st071382|FD-Score:4.44|P-value:1.34E-5 ID:SGTC_1986|Compound:st071812|FD-Score:5.95|P-value:8.71E-9 ID:SGTC_1994|Compound:st072947|FD-Score:4.16|P-value:4.12E-5 ID:SGTC_2000|Compound:st075254|FD-Score:3.48|P-value:5.01E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.90|P-value:1.08E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.10|P-value:5.28E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.23|P-value:3.11E-5 ID:SGTC_3040|Compound:9091894|FD-Score:4.23|P-value:3.12E-5 ID:SGTC_3093|Compound:9117344|FD-Score:3.75|P-value:1.92E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.30|P-value:9.03E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.57|P-value:3.66E-4 ID:SGTC_3310|Compound:9130229|FD-Score:5.63|P-value:4.99E-8

Top fitness defect scores for YGL041C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 8.03 12.5 mM 1.47E-14 DNA intercalators 12 5.01E-16
2 SGTC_471 1-acyl-paf 6.20 4.0 µM 2.22E-9 DNA intercalators 5 2.90E-10
3 SGTC_1986 st071812 5.95 45.0 µM 8.71E-9 1 1.33E-9
4 SGTC_3310 9130229 5.63 44.1 µM 4.99E-8 Golgi 6 9.23E-9
5 SGTC_145 3737-0113 5.08 38.4 µM 7.73E-7 DNA intercalators 42 1.94E-7
6 SGTC_219 mitoxanthrone 4.92 164.4 µM 1.56E-6 DNA intercalators 27 4.23E-7
7 SGTC_9 0092-0002 4.85 10.4 µM 2.21E-6 14 6.21E-7
8 SGTC_1926 methyl fluorone black 4.73 53.6 µM 3.70E-6 DNA intercalators 40 1.10E-6
9 SGTC_1985 st071382 4.44 65.5 µM 1.34E-5 12 4.59E-6
10 SGTC_1199 1638-0010 4.31 4.5 µM 2.27E-5 endomembrane recycling 17 8.26E-6
11 SGTC_301 4119-0100 4.30 24.5 µM 2.34E-5 NEO1 72 8.53E-6
12 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 4.23 15.3 µM 3.11E-5 26 1.17E-5
13 SGTC_3040 9091894 4.23 49.5 µM 3.12E-5 DNA intercalators 18 1.17E-5
14 SGTC_1984 st072354 4.23 53.1 µM 3.14E-5 11 1.18E-5
15 SGTC_1316 1272-0050 4.19 65.9 µM 3.64E-5 5 1.40E-5
16 SGTC_1994 st072947 4.16 40.9 µM 4.12E-5 10 1.60E-5
17 SGTC_2104 5389443 4.10 200.0 µM 5.28E-5 12 2.11E-5
18 SGTC_302 1094-0063 4.06 18.9 µM 5.99E-5 11 2.42E-5
19 SGTC_1582 3',3',6'-trihydroxyflavone 4.06 74.0 µM 6.13E-5 9 2.48E-5
20 SGTC_1515 3460-0031 4.01 42.1 µM 7.30E-5 DNA intercalators 18 3.01E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.390 6.76E-122 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.385 1.18E-118 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.376 6.93E-113 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.371 2.06E-109 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.342 3.62E-92 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.333 1.04E-87 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.329 2.33E-85 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.320 2.57E-80 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.304 1.02E-72 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.278 2.25E-60 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.267 7.85E-56 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.249 1.92E-48 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.236 1.93E-43 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.233 2.56E-42 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.201 9.78E-32 YLR133W CKI1 hom Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication