YGL041C-B_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL041C-B / YGL041C-B

Click on Significant Values for Screen Details ID:SGTC_50|Compound:0929-0078|FD-Score:-3.25|P-value:1.99E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.05|P-value:4.55E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.68|P-value:3.38E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:6.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:7.06E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:2.87|P-value:9.37E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:4.81|P-value:9.16E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.88|P-value:8.54E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.05|P-value:4.74E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.47|P-value:8.44E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-2.88|P-value:8.68E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.21|P-value:2.28E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.06|P-value:5.44E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.97|P-value:6.54E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.00|P-value:5.39E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.08|P-value:4.23E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.11|P-value:3.76E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.48|P-value:1.36E-9 ID:SGTC_1976|Compound:st070609|FD-Score:2.97|P-value:6.42E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.71|P-value:1.67E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.54|P-value:6.22E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-4.31|P-value:1.39E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.86|P-value:1.31E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.87|P-value:1.27E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.04|P-value:5.01E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.25|P-value:2.15E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.02|P-value:5.43E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.64|P-value:3.72E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-4.52|P-value:4.40E-7 ID:SGTC_2947|Compound:9072639|FD-Score:-5.30|P-value:4.21E-9 ID:SGTC_2950|Compound:9072895|FD-Score:4.93|P-value:4.56E-8 ID:SGTC_2970|Compound:9090938|FD-Score:4.44|P-value:7.35E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-4.50|P-value:4.94E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-3.06|P-value:4.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.02|P-value:5.10E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.46|P-value:8.91E-5 ID:SGTC_3094|Compound:9117742|FD-Score:4.40|P-value:9.39E-7 ID:SGTC_3148|Compound:9097893|FD-Score:-3.23|P-value:2.22E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.40|P-value:1.07E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.72|P-value:1.58E-7 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.25|P-value:1.99E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-3.05|P-value:4.55E-4 ID:SGTC_180|Compound:1486-1293|FD-Score:3.68|P-value:3.38E-5 ID:SGTC_182|Compound:3448-4371|FD-Score:3.54|P-value:6.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:2.95|P-value:7.06E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.92|P-value:1.07E-5 ID:SGTC_316|Compound:k060-0003|FD-Score:2.87|P-value:9.37E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:4.81|P-value:9.16E-8 ID:SGTC_525|Compound:k781-2675|FD-Score:-2.88|P-value:8.54E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-2.92|P-value:7.27E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:3.05|P-value:4.74E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.23|P-value:2.37E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.47|P-value:8.44E-5 ID:SGTC_917|Compound:harmaline|FD-Score:-2.88|P-value:8.68E-4 ID:SGTC_952|Compound:1185-0122|FD-Score:-4.21|P-value:2.28E-6 ID:SGTC_1171|Compound:0368-0077|FD-Score:-3.05|P-value:4.50E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:4.06|P-value:5.44E-6 ID:SGTC_1320|Compound:1313-0481|FD-Score:2.97|P-value:6.54E-4 ID:SGTC_1386|Compound:3228-0095|FD-Score:-3.00|P-value:5.39E-4 ID:SGTC_1716|Compound:st033144|FD-Score:3.08|P-value:4.23E-4 ID:SGTC_1813|Compound:st051246|FD-Score:3.11|P-value:3.76E-4 ID:SGTC_1946|Compound:st076057|FD-Score:3.11|P-value:3.77E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.48|P-value:1.36E-9 ID:SGTC_1976|Compound:st070609|FD-Score:2.97|P-value:6.42E-4 ID:SGTC_2037|Compound:5169046|FD-Score:4.71|P-value:1.67E-7 ID:SGTC_2354|Compound:9060492|FD-Score:3.39|P-value:1.20E-4 ID:SGTC_2355|Compound:9061122|FD-Score:3.54|P-value:6.22E-5 ID:SGTC_2446|Compound:5162541|FD-Score:-4.31|P-value:1.39E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.86|P-value:1.31E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.87|P-value:1.27E-5 ID:SGTC_2605|Compound:digitonin|FD-Score:3.00|P-value:5.77E-4 ID:SGTC_2794|Compound:7785382|FD-Score:3.04|P-value:5.01E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.25|P-value:2.15E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.02|P-value:5.43E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.64|P-value:3.72E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-4.52|P-value:4.40E-7 ID:SGTC_2947|Compound:9072639|FD-Score:-5.30|P-value:4.21E-9 ID:SGTC_2950|Compound:9072895|FD-Score:4.93|P-value:4.56E-8 ID:SGTC_2970|Compound:9090938|FD-Score:4.44|P-value:7.35E-7 ID:SGTC_2971|Compound:9092186|FD-Score:-4.50|P-value:4.94E-7 ID:SGTC_2991|Compound:9074669|FD-Score:-3.06|P-value:4.29E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-3.02|P-value:5.10E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.46|P-value:8.91E-5 ID:SGTC_3094|Compound:9117742|FD-Score:4.40|P-value:9.39E-7 ID:SGTC_3148|Compound:9097893|FD-Score:-3.23|P-value:2.22E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.40|P-value:1.07E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.72|P-value:1.58E-7

Top fitness defect scores for YGL041C-B deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1948 st076329 5.48 66.6 µM 1.36E-9 6 2.07E-8
2 SGTC_2950 9072895 4.93 21.5 µM 4.56E-8 16 4.14E-7
3 SGTC_336 4111-0029 4.81 111.0 µM 9.16E-8 4 7.51E-7
4 SGTC_3300 9124615 4.72 50.5 µM 1.58E-7 7 1.19E-6
5 SGTC_2037 5169046 4.71 200.0 µM 1.67E-7 60S ribosome export 6 1.25E-6
6 SGTC_2970 9090938 4.44 41.9 µM 7.35E-7 RNA processing & uracil transport 24 4.45E-6
7 SGTC_3094 9117742 4.40 49.5 µM 9.39E-7 13 5.49E-6
8 SGTC_1214 0358-0031 4.06 63.7 µM 5.44E-6 15 2.47E-5
9 SGTC_275 trichlorophene 3.92 5.7 µM 1.07E-5 mitochondrial stress 230 4.40E-5
10 SGTC_180 1486-1293 3.68 102.8 µM 3.38E-5 45 1.18E-4
11 SGTC_2355 9061122 3.54 103.1 µM 6.22E-5 18 1.99E-4
12 SGTC_182 3448-4371 3.54 550.5 µM 6.40E-5 33 2.04E-4
13 SGTC_894 0960-0238 3.47 55.9 µM 8.44E-5 20 2.58E-4
14 SGTC_3091 9116372 3.46 49.5 µM 8.91E-5 26 2.71E-4
15 SGTC_2354 9060492 3.39 162.0 µM 1.20E-4 35 3.49E-4
16 SGTC_2829 7992743 3.25 58.4 µM 2.15E-4 68 5.75E-4
17 SGTC_852 0418-0143 3.23 439.0 µM 2.37E-4 calcium & mitochondrial duress 113 6.27E-4
18 SGTC_1813 st051246 3.11 8.6 µM 3.76E-4 TSC3-RPN4 27 9.32E-4
19 SGTC_1946 st076057 3.11 65.1 µM 3.77E-4 19 9.35E-4
20 SGTC_1716 st033144 3.08 30.6 µM 4.23E-4 46 0.00103

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.94E-17 YMR313C TGL3 hom Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation
0.127 1.41E-13 YGR295C COS6 hom Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
0.120 2.60E-12 YDR314C RAD34 hom Protein involved in nucleotide excision repair (NER); homologous to RAD4
0.119 3.80E-12 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.118 6.93E-12 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.109 2.65E-10 YDR382W RPP2B hom Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
0.109 2.78E-10 YLR129W DIP2 het Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
0.107 5.07E-10 YJR002W MPP10 het Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
0.106 7.82E-10 YDR322W MRPL35 hom Mitochondrial ribosomal protein of the large subunit
0.098 1.16E-8 YGR041W BUD9 hom Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole
0.097 1.59E-8 YOL102C TPT1 het tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
0.097 1.91E-8 YMR322C_p SNO4_p hom Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
0.096 2.86E-8 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.096 2.54E-8 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.095 3.06E-8 YFL014W HSP12 hom Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension