YGL042C_d

Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1

Zygosity: Homozygous strain
fixedexpanded
Profile for YGL042C / YGL042C

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:4.07|P-value:2.25E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.87|P-value:5.36E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.47|P-value:4.73E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:32.30|P-value:4.33E-230 ID:SGTC_104|Compound:0074-0074|FD-Score:3.37|P-value:3.71E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:7.39|P-value:6.86E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.85|P-value:5.58E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.74|P-value:8.87E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.23|P-value:5.93E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.85|P-value:5.68E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.19|P-value:6.93E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.21|P-value:6.61E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-5.54|P-value:1.37E-8 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.60|P-value:1.05E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:-5.74|P-value:4.25E-9 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.50|P-value:2.30E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.45|P-value:2.81E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.42|P-value:3.02E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.19|P-value:7.05E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.16|P-value:7.58E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.23|P-value:2.17E-10 ID:SGTC_1800|Compound:st050079|FD-Score:6.14|P-value:3.99E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.48|P-value:3.60E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.73|P-value:1.09E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.13|P-value:8.64E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.07|P-value:5.99E-10 ID:SGTC_1974|Compound:st069448|FD-Score:3.99|P-value:3.24E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.24|P-value:6.01E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.50|P-value:2.32E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.92|P-value:4.32E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.46|P-value:2.62E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.16|P-value:7.71E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.15|P-value:1.59E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.75|P-value:9.91E-7 ID:SGTC_2701|Compound:st077767|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.32|P-value:7.49E-6 ID:SGTC_3012|Compound:9080433|FD-Score:-3.75|P-value:8.62E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.14|P-value:8.24E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.23|P-value:2.18E-13 ID:SGTC_3287|Compound:9117173|FD-Score:-3.33|P-value:4.22E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.07|P-value:2.25E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.87|P-value:5.36E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:6.47|P-value:4.73E-11 ID:SGTC_72|Compound:0744-0168|FD-Score:32.30|P-value:4.33E-230 ID:SGTC_104|Compound:0074-0074|FD-Score:3.37|P-value:3.71E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:7.39|P-value:6.86E-14 ID:SGTC_149|Compound:3970-0822|FD-Score:4.15|P-value:1.62E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:3.22|P-value:6.40E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.85|P-value:5.58E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.74|P-value:8.87E-5 ID:SGTC_575|Compound:k072-0246|FD-Score:-3.66|P-value:1.20E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:-3.23|P-value:5.93E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:-3.85|P-value:5.68E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.19|P-value:6.93E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:3.21|P-value:6.61E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:-5.54|P-value:1.37E-8 ID:SGTC_1339|Compound:1486-1321|FD-Score:5.60|P-value:1.05E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:-5.74|P-value:4.25E-9 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.50|P-value:2.30E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.45|P-value:2.81E-4 ID:SGTC_1616|Compound:st002734|FD-Score:-3.42|P-value:3.02E-4 ID:SGTC_1629|Compound:st005085|FD-Score:3.19|P-value:7.05E-4 ID:SGTC_1705|Compound:st027868|FD-Score:-3.16|P-value:7.58E-4 ID:SGTC_1754|Compound:st042065|FD-Score:6.23|P-value:2.17E-10 ID:SGTC_1800|Compound:st050079|FD-Score:6.14|P-value:3.99E-10 ID:SGTC_1801|Compound:st050089|FD-Score:4.48|P-value:3.60E-6 ID:SGTC_1803|Compound:st050068|FD-Score:3.61|P-value:1.50E-4 ID:SGTC_1818|Compound:st052136|FD-Score:4.73|P-value:1.09E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:3.13|P-value:8.64E-4 ID:SGTC_1941|Compound:st076221|FD-Score:6.07|P-value:5.99E-10 ID:SGTC_1974|Compound:st069448|FD-Score:3.99|P-value:3.24E-5 ID:SGTC_2013|Compound:4024628|FD-Score:3.24|P-value:6.01E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.50|P-value:2.32E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.92|P-value:4.32E-5 ID:SGTC_2031|Compound:5180455|FD-Score:3.46|P-value:2.62E-4 ID:SGTC_2101|Compound:5377231|FD-Score:-3.16|P-value:7.71E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-4.15|P-value:1.59E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.75|P-value:9.91E-7 ID:SGTC_2701|Compound:st077767|FD-Score:3.17|P-value:7.56E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-4.32|P-value:7.49E-6 ID:SGTC_3012|Compound:9080433|FD-Score:-3.75|P-value:8.62E-5 ID:SGTC_3029|Compound:9088683|FD-Score:3.14|P-value:8.24E-4 ID:SGTC_3037|Compound:9091026|FD-Score:7.23|P-value:2.18E-13 ID:SGTC_3287|Compound:9117173|FD-Score:-3.33|P-value:4.22E-4

Top fitness defect scores for YGL042C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_72 0744-0168 32.30 198.4 µM 4.33E-230 RPP1 & pyrimidine depletion 1 3.33E-229
2 SGTC_108 0509-0257 7.39 621.1 µM 6.86E-14 7 7.50E-14
3 SGTC_3037 9091026 7.23 49.5 µM 2.18E-13 NEO1-PIK1 23 2.37E-13
4 SGTC_59 0330-0160 6.47 1.3 µM 4.73E-11 30 5.06E-11
5 SGTC_1754 st042065 6.23 16.1 µM 2.17E-10 NEO1-PIK1 93 2.31E-10
6 SGTC_1800 st050079 6.14 29.1 µM 3.99E-10 NEO1-PIK1 34 4.23E-10
7 SGTC_1941 st076221 6.07 61.8 µM 5.99E-10 sphingolipid biosynthesis & PDR1 31 6.35E-10
8 SGTC_1339 1486-1321 5.60 22.7 µM 1.05E-8 ERG2 4 1.10E-8
9 SGTC_2679 rapamycin 4.75 1.0 nM 9.91E-7 104 1.02E-6
10 SGTC_1818 st052136 4.73 56.3 µM 1.09E-6 NEO1-PIK1 26 1.13E-6
11 SGTC_1801 st050089 4.48 28.4 µM 3.60E-6 NEO1-PIK1 93 3.70E-6
12 SGTC_149 3970-0822 4.15 46.1 µM 1.62E-5 tubulin folding & SWR complex 88 1.66E-5
13 SGTC_15 0266-0086 4.07 27.1 µM 2.25E-5 endomembrane recycling 58 2.30E-5
14 SGTC_1974 st069448 3.99 26.9 µM 3.24E-5 21 3.30E-5
15 SGTC_2026 5148700 3.92 152.0 µM 4.32E-5 16 4.40E-5
16 SGTC_43 0570-0105 3.87 72.5 µM 5.36E-5 ERG2 99 5.46E-5
17 SGTC_528 3492-0019 3.74 172.0 µM 8.87E-5 calcium & mitochondrial duress 237 9.03E-5
18 SGTC_1803 st050068 3.61 52.4 µM 1.50E-4 NEO1-PIK1 205 1.53E-4
19 SGTC_1342 1486-1464 3.50 234.0 µM 2.30E-4 26 2.33E-4
20 SGTC_2018 5133068 3.50 143.0 µM 2.32E-4 35 2.36E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.312 2.02E-76 YGL043W DST1 hom General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress
0.190 1.54E-28 YKR095W MLP1 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
0.184 5.25E-27 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
0.176 1.10E-24 YKL124W SSH4 hom Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases
0.167 2.42E-22 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.165 6.65E-22 YLR272C YCS4 het Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation
0.155 1.72E-19 YLR022C SDO1 het Essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes
0.154 2.76E-19 YKL193C SDS22 het Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function
0.151 1.34E-18 YKR073C_d YKR073C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.150 2.40E-18 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.148 7.53E-18 YDR345C HXT3 hom Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication
0.147 1.27E-17 YPL202C AFT2 hom Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication
0.146 2.03E-17 YBR097W VPS15 hom Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery
0.139 5.14E-16 YOR357C SNX3 hom Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.138 1.10E-15 YHR187W IKI1 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin