HIPHOP chemogenomics database
YGL050W / TYW3 
tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
Zygosity: Homozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YGL050W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.164 | 1.33E-21 | YDR107C | TMN2 | hom | Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments |
| 0.152 | 7.30E-19 | YGR022C_d | YGR022C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W |
| 0.136 | 2.80E-15 | YBL017C | PEP1 | hom | Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments |
| 0.121 | 2.44E-12 | YDR294C | DPL1 | hom | Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate |
| 0.109 | 2.74E-10 | YGR292W | MAL12 | hom | Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose |
| 0.107 | 4.83E-10 | YDR109C_p | YDR109C_p | hom | Putative kinase |
| 0.098 | 1.28E-8 | YOR114W_p | YOR114W_p | hom | Putative protein of unknown function; null mutant is viable |
| 0.092 | 8.95E-8 | YOR017W | PET127 | hom | Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane |
| 0.092 | 1.01E-7 | YOL101C | IZH4 | hom | Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress |
| 0.091 | 1.27E-7 | YDL086W_p | YDL086W_p | hom | Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene |
| 0.089 | 2.10E-7 | YBL001C | ECM15 | hom | Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis |
| 0.089 | 2.71E-7 | YKR102W | FLO10 | hom | Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth |
| 0.088 | 2.96E-7 | YJL051W | IRC8 | hom | Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc |
| 0.087 | 4.44E-7 | YOL060C | MAM3 | hom | Protein required for normal mitochondrial morphology, has similarity to hemolysins |
| 0.087 | 4.81E-7 | YDL222C | FMP45 | hom | Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C |