HIPHOP chemogenomics database

YGL064C / MRH4

Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function

Zygosity: Homozygous strain

fixedexpanded
Profile for YGL064C / MRH4

Click on Significant Values for Screen Details

Top fitness defect scores for YGL064C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_173	1273-0061	14.80	2.7 µM	3.84E-46	mitochondrial stress	8	6.30E-50
2	SGTC_236	1509-0011	13.30	5.3 µM	1.26E-37		132	1.09E-40
3	SGTC_1742	st038235	12.80	28.9 µM	6.31E-35	mitochondrial stress	3	9.18E-38
4	SGTC_386	1509-0011	9.18	3.1 µM	6.73E-19		52	2.22E-20
5	SGTC_310	1273-0058	7.83	1.1 µM	3.02E-14	mitochondrial stress	98	2.46E-15
6	SGTC_908	3448-7491	7.78	47.7 µM	4.42E-14	mitochondrial stress	19	3.71E-15
7	SGTC_275	trichlorophene	7.47	5.7 µM	4.06E-13	mitochondrial stress	86	4.11E-14
8	SGTC_70	0141-0289	6.41	43.3 µM	4.06E-10	mitochondrial stress	70	7.35E-11
9	SGTC_778	3456-2434	6.28	196.0 µM	8.93E-10	mitochondrial response to ROS	22	1.73E-10
10	SGTC_3194	9111903	6.06	49.5 µM	3.24E-9		6	6.99E-10
11	SGTC_116	0155-0182	5.63	31.8 µM	3.40E-8	mitochondrial response to ROS	30	8.93E-9
12	SGTC_119	0121-0043	5.34	24.8 µM	1.57E-7	mitochondrial stress	41	4.68E-8
13	SGTC_10	0279-0212	5.23	42.6 µM	2.68E-7	TRP & mitochondrial translation	52	8.37E-8
14	SGTC_791	1348-1292	5.12	225.0 µM	4.60E-7		16	1.50E-7
15	SGTC_68	0986-0284	5.12	82.8 µM	4.65E-7		26	1.52E-7
16	SGTC_520	3584-0023	4.82	682.0 µM	1.97E-6		12	7.26E-7
17	SGTC_629	3448-6466	4.79	76.7 µM	2.26E-6		6	8.45E-7
18	SGTC_2250	alverine citrate	4.55	130.0 µM	6.51E-6		121	2.65E-6
19	SGTC_1882	5615643	4.53	20.0 µM	7.18E-6	TRP & mitochondrial translation	18	2.95E-6
20	SGTC_1883	5-benzylidenerhodanine	4.44	20.0 µM	1.06E-5	TRP & mitochondrial translation	51	4.50E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.550	4.00E-265	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.518	8.44E-230	YPR166C	MRP2	hom	Mitochondrial ribosomal protein of the small subunit
0.516	4.95E-228	YDR237W	MRPL7	hom	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein
0.516	2.33E-227	YNL252C	MRPL17	hom	Mitochondrial ribosomal protein of the large subunit
0.511	1.48E-222	YMR072W	ABF2	hom	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.506	1.40E-217	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.502	1.54E-213	YCR024C	SLM5	hom	Mitochondrial asparaginyl-tRNA synthetase
0.490	3.49E-202	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.486	1.65E-198	YDR065W	RRG1	hom	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.486	3.43E-198	YDR337W	MRPS28	hom	Mitochondrial ribosomal protein of the small subunit
0.485	1.39E-197	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.478	5.99E-191	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.478	7.14E-191	YOR158W	PET123	hom	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.474	1.36E-187	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.473	5.46E-186	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs